Diagnostic value of multiple diagnostic methods for lymph node metastases of papillary thyroid carcinoma: A systematic review and meta-analysis
ObjectiveThis study compared the diagnostic value of various diagnostic methods for lymph node metastasis (LNM) of papillary thyroid carcinoma (PTC) through network meta-analysis.MethodsIn this experiment, databases such as CNKI, Wanfang, PubMed, and Web of Science were retrieved according to the Co...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.990603/full |
| _version_ | 1817976014506033152 |
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| author | Si-Rui Wang Si-Rui Wang Qiao-Li Li Qiao-Li Li Feng Tian Jun Li Jun Li Wen-Xiao Li Wen-Xiao Li Ming Chen Tian Sang Tian Sang Chun-Li Cao Li-Nan Shi Li-Nan Shi |
| author_facet | Si-Rui Wang Si-Rui Wang Qiao-Li Li Qiao-Li Li Feng Tian Jun Li Jun Li Wen-Xiao Li Wen-Xiao Li Ming Chen Tian Sang Tian Sang Chun-Li Cao Li-Nan Shi Li-Nan Shi |
| author_sort | Si-Rui Wang |
| collection | DOAJ |
| description | ObjectiveThis study compared the diagnostic value of various diagnostic methods for lymph node metastasis (LNM) of papillary thyroid carcinoma (PTC) through network meta-analysis.MethodsIn this experiment, databases such as CNKI, Wanfang, PubMed, and Web of Science were retrieved according to the Cochrane database, Prisma, and NMAP command manual. A meta-analysis was performed using STATA 15.0, and the value of the surface under the cumulative ranking curve (SUCRA) was used to determine the most effective diagnostic method. Quality assessments were performed using the Cochrane Collaboration’s risk of bias tool, and publication bias was assessed using Deeks’ funnel plot.ResultsA total of 38 articles with a total of 6285 patients were included. A total of 12 diagnostic methods were used to study patients with LNM of PTC. The results showed that 12 studies were direct comparisons and 8 studies were indirect comparisons. According to the comprehensive analysis of the area of SUCRA, US+CT(86.8) had the highest sensitivity, FNAC had the highest specificity (92.4) and true positive predictive value (89.4), and FNAC+FNA-Tg had higher negative predictive value (99.4) and accuracy (86.8). In the non-invasive method, US+CT had the highest sensitivity, and the sensitivity (SEN) was [OR=0.59, 95% confidence interval (CI): (0.30, 0.89]. Among the invasive methods, the combined application of FNAC+FNA-Tg had higher diagnostic performance. The sensitivity was [OR=0.62, 95% CI: (0.26, 0.98)], the specificity (SPE) was [OR=1.12, 95% CI: (0.59, 1.64)], the positive predictive value was [OR=0.98, 95% CI: (0.59, 1.37)], the negative predictive value was [OR=0.64, 95% CI (0.38, 0.90)], and the accuracy was [OR=0.71, 95% CI: (0.31, 1.12)].ConclusionIn the non-invasive method, the combined application of US+CT had good diagnostic performance, and in the invasive method, the combined application of FNAC+FNA-Tg had high diagnostic performance, and the above two methods were recommended. |
| first_indexed | 2024-04-13T21:56:58Z |
| format | Article |
| id | doaj.art-ff081314187c495f88de28848768125f |
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| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T21:56:58Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ff081314187c495f88de28848768125f2022-12-22T02:28:13ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.990603990603Diagnostic value of multiple diagnostic methods for lymph node metastases of papillary thyroid carcinoma: A systematic review and meta-analysisSi-Rui Wang0Si-Rui Wang1Qiao-Li Li2Qiao-Li Li3Feng Tian4Jun Li5Jun Li6Wen-Xiao Li7Wen-Xiao Li8Ming Chen9Tian Sang10Tian Sang11Chun-Li Cao12Li-Nan Shi13Li-Nan Shi14Department of Ultrasound, the First Affiliated Hospital of Medical College, Shihezi University, Shihezi, Xinjiang, ChinaNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), Shihezi, Xinjiang, ChinaDepartment of Ultrasound, the First Affiliated Hospital of Medical College, Shihezi University, Shihezi, Xinjiang, ChinaNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), Shihezi, Xinjiang, ChinaDepartment of Neurology, the First Affiliated Hospital of Medical College, Shihezi University, Shihezi, Xinjiang, ChinaDepartment of Ultrasound, the First Affiliated Hospital of Medical College, Shihezi University, Shihezi, Xinjiang, ChinaNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), Shihezi, Xinjiang, ChinaDepartment of Ultrasound, the First Affiliated Hospital of Medical College, Shihezi University, Shihezi, Xinjiang, ChinaNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), Shihezi, Xinjiang, ChinaDepartment of Ultrasound, the First Affiliated Hospital of Medical College, Shihezi University, Shihezi, Xinjiang, ChinaDepartment of Ultrasound, the First Affiliated Hospital of Medical College, Shihezi University, Shihezi, Xinjiang, ChinaNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), Shihezi, Xinjiang, ChinaDepartment of Ultrasound, the First Affiliated Hospital of Medical College, Shihezi University, Shihezi, Xinjiang, ChinaDepartment of Ultrasound, the First Affiliated Hospital of Medical College, Shihezi University, Shihezi, Xinjiang, ChinaNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), Shihezi, Xinjiang, ChinaObjectiveThis study compared the diagnostic value of various diagnostic methods for lymph node metastasis (LNM) of papillary thyroid carcinoma (PTC) through network meta-analysis.MethodsIn this experiment, databases such as CNKI, Wanfang, PubMed, and Web of Science were retrieved according to the Cochrane database, Prisma, and NMAP command manual. A meta-analysis was performed using STATA 15.0, and the value of the surface under the cumulative ranking curve (SUCRA) was used to determine the most effective diagnostic method. Quality assessments were performed using the Cochrane Collaboration’s risk of bias tool, and publication bias was assessed using Deeks’ funnel plot.ResultsA total of 38 articles with a total of 6285 patients were included. A total of 12 diagnostic methods were used to study patients with LNM of PTC. The results showed that 12 studies were direct comparisons and 8 studies were indirect comparisons. According to the comprehensive analysis of the area of SUCRA, US+CT(86.8) had the highest sensitivity, FNAC had the highest specificity (92.4) and true positive predictive value (89.4), and FNAC+FNA-Tg had higher negative predictive value (99.4) and accuracy (86.8). In the non-invasive method, US+CT had the highest sensitivity, and the sensitivity (SEN) was [OR=0.59, 95% confidence interval (CI): (0.30, 0.89]. Among the invasive methods, the combined application of FNAC+FNA-Tg had higher diagnostic performance. The sensitivity was [OR=0.62, 95% CI: (0.26, 0.98)], the specificity (SPE) was [OR=1.12, 95% CI: (0.59, 1.64)], the positive predictive value was [OR=0.98, 95% CI: (0.59, 1.37)], the negative predictive value was [OR=0.64, 95% CI (0.38, 0.90)], and the accuracy was [OR=0.71, 95% CI: (0.31, 1.12)].ConclusionIn the non-invasive method, the combined application of US+CT had good diagnostic performance, and in the invasive method, the combined application of FNAC+FNA-Tg had high diagnostic performance, and the above two methods were recommended.https://www.frontiersin.org/articles/10.3389/fonc.2022.990603/fulllymph nodes metastasisdiagnostic valuenetwork meta-analysismultiple diagnostic methodspapillary thyroid carcinoma |
| spellingShingle | Si-Rui Wang Si-Rui Wang Qiao-Li Li Qiao-Li Li Feng Tian Jun Li Jun Li Wen-Xiao Li Wen-Xiao Li Ming Chen Tian Sang Tian Sang Chun-Li Cao Li-Nan Shi Li-Nan Shi Diagnostic value of multiple diagnostic methods for lymph node metastases of papillary thyroid carcinoma: A systematic review and meta-analysis Frontiers in Oncology lymph nodes metastasis diagnostic value network meta-analysis multiple diagnostic methods papillary thyroid carcinoma |
| title | Diagnostic value of multiple diagnostic methods for lymph node metastases of papillary thyroid carcinoma: A systematic review and meta-analysis |
| title_full | Diagnostic value of multiple diagnostic methods for lymph node metastases of papillary thyroid carcinoma: A systematic review and meta-analysis |
| title_fullStr | Diagnostic value of multiple diagnostic methods for lymph node metastases of papillary thyroid carcinoma: A systematic review and meta-analysis |
| title_full_unstemmed | Diagnostic value of multiple diagnostic methods for lymph node metastases of papillary thyroid carcinoma: A systematic review and meta-analysis |
| title_short | Diagnostic value of multiple diagnostic methods for lymph node metastases of papillary thyroid carcinoma: A systematic review and meta-analysis |
| title_sort | diagnostic value of multiple diagnostic methods for lymph node metastases of papillary thyroid carcinoma a systematic review and meta analysis |
| topic | lymph nodes metastasis diagnostic value network meta-analysis multiple diagnostic methods papillary thyroid carcinoma |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.990603/full |
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