Smart Gold Nanostructures for Light Mediated Cancer Theranostics: Combining Optical Diagnostics with Photothermal Therapy
Abstract Nanotheranostics, which combines optical multiplexed disease detection with therapeutic monitoring in a single modality, has the potential to propel the field of nanomedicine toward genuine personalized medicine. Currently employed mainstream modalities using gold nanoparticles (AuNPs) in d...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-08-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.201903441 |
| _version_ | 1818007477042544640 |
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| author | Tanveer A. Tabish Priyanka Dey Sara Mosca Marzieh Salimi Francesca Palombo Pavel Matousek Nicholas Stone |
| author_facet | Tanveer A. Tabish Priyanka Dey Sara Mosca Marzieh Salimi Francesca Palombo Pavel Matousek Nicholas Stone |
| author_sort | Tanveer A. Tabish |
| collection | DOAJ |
| description | Abstract Nanotheranostics, which combines optical multiplexed disease detection with therapeutic monitoring in a single modality, has the potential to propel the field of nanomedicine toward genuine personalized medicine. Currently employed mainstream modalities using gold nanoparticles (AuNPs) in diagnosis and treatment are limited by a lack of specificity and potential issues associated with systemic toxicity. Light‐mediated nanotheranostics offers a relatively non‐invasive alternative for cancer diagnosis and treatment by using AuNPs of specific shapes and sizes that absorb near infrared (NIR) light, inducing plasmon resonance for enhanced tumor detection and generating localized heat for tumor ablation. Over the last decade, significant progress has been made in the field of nanotheranostics, however the main biological and translational barriers to nanotheranostics leading to a new paradigm in anti‐cancer nanomedicine stem from the molecular complexities of cancer and an incomplete mechanistic understanding of utilization of Au‐NPs in living systems. This work provides a comprehensive overview on the biological, physical and translational barriers facing the development of nanotheranostics. It will also summarise the recent advances in engineering specific AuNPs, their unique characteristics and, importantly, tunability to achieve the desired optical/photothermal properties. |
| first_indexed | 2024-04-14T05:16:04Z |
| format | Article |
| id | doaj.art-ff08543c55a244828a2f832860519cf8 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-14T05:16:04Z |
| publishDate | 2020-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-ff08543c55a244828a2f832860519cf82022-12-22T02:10:22ZengWileyAdvanced Science2198-38442020-08-01715n/an/a10.1002/advs.201903441Smart Gold Nanostructures for Light Mediated Cancer Theranostics: Combining Optical Diagnostics with Photothermal TherapyTanveer A. Tabish0Priyanka Dey1Sara Mosca2Marzieh Salimi3Francesca Palombo4Pavel Matousek5Nicholas Stone6School of Physics and Astronomy University of Exeter Exeter EX4 4QL UKSchool of Physics and Astronomy University of Exeter Exeter EX4 4QL UKCentral Laser Facility STFC Rutherford Appleton Laboratory Oxford OX11 0QX UKSchool of Physics and Astronomy University of Exeter Exeter EX4 4QL UKSchool of Physics and Astronomy University of Exeter Exeter EX4 4QL UKCentral Laser Facility STFC Rutherford Appleton Laboratory Oxford OX11 0QX UKSchool of Physics and Astronomy University of Exeter Exeter EX4 4QL UKAbstract Nanotheranostics, which combines optical multiplexed disease detection with therapeutic monitoring in a single modality, has the potential to propel the field of nanomedicine toward genuine personalized medicine. Currently employed mainstream modalities using gold nanoparticles (AuNPs) in diagnosis and treatment are limited by a lack of specificity and potential issues associated with systemic toxicity. Light‐mediated nanotheranostics offers a relatively non‐invasive alternative for cancer diagnosis and treatment by using AuNPs of specific shapes and sizes that absorb near infrared (NIR) light, inducing plasmon resonance for enhanced tumor detection and generating localized heat for tumor ablation. Over the last decade, significant progress has been made in the field of nanotheranostics, however the main biological and translational barriers to nanotheranostics leading to a new paradigm in anti‐cancer nanomedicine stem from the molecular complexities of cancer and an incomplete mechanistic understanding of utilization of Au‐NPs in living systems. This work provides a comprehensive overview on the biological, physical and translational barriers facing the development of nanotheranostics. It will also summarise the recent advances in engineering specific AuNPs, their unique characteristics and, importantly, tunability to achieve the desired optical/photothermal properties.https://doi.org/10.1002/advs.201903441diagnosticsgold nanostructureslightphotothermal therapytheranostics |
| spellingShingle | Tanveer A. Tabish Priyanka Dey Sara Mosca Marzieh Salimi Francesca Palombo Pavel Matousek Nicholas Stone Smart Gold Nanostructures for Light Mediated Cancer Theranostics: Combining Optical Diagnostics with Photothermal Therapy Advanced Science diagnostics gold nanostructures light photothermal therapy theranostics |
| title | Smart Gold Nanostructures for Light Mediated Cancer Theranostics: Combining Optical Diagnostics with Photothermal Therapy |
| title_full | Smart Gold Nanostructures for Light Mediated Cancer Theranostics: Combining Optical Diagnostics with Photothermal Therapy |
| title_fullStr | Smart Gold Nanostructures for Light Mediated Cancer Theranostics: Combining Optical Diagnostics with Photothermal Therapy |
| title_full_unstemmed | Smart Gold Nanostructures for Light Mediated Cancer Theranostics: Combining Optical Diagnostics with Photothermal Therapy |
| title_short | Smart Gold Nanostructures for Light Mediated Cancer Theranostics: Combining Optical Diagnostics with Photothermal Therapy |
| title_sort | smart gold nanostructures for light mediated cancer theranostics combining optical diagnostics with photothermal therapy |
| topic | diagnostics gold nanostructures light photothermal therapy theranostics |
| url | https://doi.org/10.1002/advs.201903441 |
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