The Role of the p16 and p53 Tumor Suppressor Proteins and Viral HPV16 E6 and E7 Oncoproteins in the Assessment of Survival in Patients with Head and Neck Cancers Associated with Human Papillomavirus Infections
The role of HPV in the survival prognosis of patients with head and neck squamous cell carcinoma, especially patients with laryngeal squamous cell carcinoma (LSCC) and hypopharyngeal squamous cell carcinoma (HPSCC), is still somewhat ambiguous. The present study aimed to explore the significance of...
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MDPI AG
2023-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/10/2722 |
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| author | Andrejs Lifsics Maksims Cistjakovs Liba Sokolovska Renars Deksnis Modra Murovska Valerija Groma |
| author_facet | Andrejs Lifsics Maksims Cistjakovs Liba Sokolovska Renars Deksnis Modra Murovska Valerija Groma |
| author_sort | Andrejs Lifsics |
| collection | DOAJ |
| description | The role of HPV in the survival prognosis of patients with head and neck squamous cell carcinoma, especially patients with laryngeal squamous cell carcinoma (LSCC) and hypopharyngeal squamous cell carcinoma (HPSCC), is still somewhat ambiguous. The present study aimed to explore the significance of tumor suppressor proteins and HPV16 E6 and E7 oncoproteins in the assessment of survival in patients with oropharyngeal squamous cell carcinoma (OPSCC), LSCC, and HPSCC associated with high-risk (HR-) and low-risk (LR-) HPV infections. By utilizing molecular and immunohistochemical investigations of HNSCC samples and patient data, univariate and multivariate survival analyses were conducted. The presence of HPV DNA (LR- and HR-HPV) was associated with a better 5-year OS and DSS for OPSCC and LSCC. The IHC overexpression of HPV16 E6 protein and p16 protein was associated with better survival in the univariate (for OPSCC) and multivariate (OPSCC and HPSCC) survival analyses. The overexpression of p53 was associated with better survival in OPSCC. HPV infection plays a significant role in the tumorigenesis of HNSCC, and the immunohistochemical assessment of HPV16 E6 protein expression should be interpreted as a useful prognostic marker for OPSCC and HPSCC. |
| first_indexed | 2024-03-11T03:53:21Z |
| format | Article |
| id | doaj.art-ff08a20cdc9042aabe177a6efdfb8f49 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T03:53:21Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ff08a20cdc9042aabe177a6efdfb8f492023-11-18T00:47:59ZengMDPI AGCancers2072-66942023-05-011510272210.3390/cancers15102722The Role of the p16 and p53 Tumor Suppressor Proteins and Viral HPV16 E6 and E7 Oncoproteins in the Assessment of Survival in Patients with Head and Neck Cancers Associated with Human Papillomavirus InfectionsAndrejs Lifsics0Maksims Cistjakovs1Liba Sokolovska2Renars Deksnis3Modra Murovska4Valerija Groma5Department of Otorhinolaryngology, Riga Stradiņš University, Pilsoņu 13, LV-1002 Riga, LatviaInstitute of Microbiology and Virology, Riga Stradiņš University, Rātsupītes 5, LV-1067 Riga, LatviaInstitute of Microbiology and Virology, Riga Stradiņš University, Rātsupītes 5, LV-1067 Riga, LatviaDepartment of Otorhinolaryngology, Riga Stradiņš University, Pilsoņu 13, LV-1002 Riga, LatviaInstitute of Microbiology and Virology, Riga Stradiņš University, Rātsupītes 5, LV-1067 Riga, LatviaInstitute of Anatomy and Anthropology, Riga Stradiņš University, Kronvalda blvd 9, LV-1010 Riga, LatviaThe role of HPV in the survival prognosis of patients with head and neck squamous cell carcinoma, especially patients with laryngeal squamous cell carcinoma (LSCC) and hypopharyngeal squamous cell carcinoma (HPSCC), is still somewhat ambiguous. The present study aimed to explore the significance of tumor suppressor proteins and HPV16 E6 and E7 oncoproteins in the assessment of survival in patients with oropharyngeal squamous cell carcinoma (OPSCC), LSCC, and HPSCC associated with high-risk (HR-) and low-risk (LR-) HPV infections. By utilizing molecular and immunohistochemical investigations of HNSCC samples and patient data, univariate and multivariate survival analyses were conducted. The presence of HPV DNA (LR- and HR-HPV) was associated with a better 5-year OS and DSS for OPSCC and LSCC. The IHC overexpression of HPV16 E6 protein and p16 protein was associated with better survival in the univariate (for OPSCC) and multivariate (OPSCC and HPSCC) survival analyses. The overexpression of p53 was associated with better survival in OPSCC. HPV infection plays a significant role in the tumorigenesis of HNSCC, and the immunohistochemical assessment of HPV16 E6 protein expression should be interpreted as a useful prognostic marker for OPSCC and HPSCC.https://www.mdpi.com/2072-6694/15/10/2722oropharynxlarynxhypopharynxsquamous cell carcinomaHPVPCR |
| spellingShingle | Andrejs Lifsics Maksims Cistjakovs Liba Sokolovska Renars Deksnis Modra Murovska Valerija Groma The Role of the p16 and p53 Tumor Suppressor Proteins and Viral HPV16 E6 and E7 Oncoproteins in the Assessment of Survival in Patients with Head and Neck Cancers Associated with Human Papillomavirus Infections Cancers oropharynx larynx hypopharynx squamous cell carcinoma HPV PCR |
| title | The Role of the p16 and p53 Tumor Suppressor Proteins and Viral HPV16 E6 and E7 Oncoproteins in the Assessment of Survival in Patients with Head and Neck Cancers Associated with Human Papillomavirus Infections |
| title_full | The Role of the p16 and p53 Tumor Suppressor Proteins and Viral HPV16 E6 and E7 Oncoproteins in the Assessment of Survival in Patients with Head and Neck Cancers Associated with Human Papillomavirus Infections |
| title_fullStr | The Role of the p16 and p53 Tumor Suppressor Proteins and Viral HPV16 E6 and E7 Oncoproteins in the Assessment of Survival in Patients with Head and Neck Cancers Associated with Human Papillomavirus Infections |
| title_full_unstemmed | The Role of the p16 and p53 Tumor Suppressor Proteins and Viral HPV16 E6 and E7 Oncoproteins in the Assessment of Survival in Patients with Head and Neck Cancers Associated with Human Papillomavirus Infections |
| title_short | The Role of the p16 and p53 Tumor Suppressor Proteins and Viral HPV16 E6 and E7 Oncoproteins in the Assessment of Survival in Patients with Head and Neck Cancers Associated with Human Papillomavirus Infections |
| title_sort | role of the p16 and p53 tumor suppressor proteins and viral hpv16 e6 and e7 oncoproteins in the assessment of survival in patients with head and neck cancers associated with human papillomavirus infections |
| topic | oropharynx larynx hypopharynx squamous cell carcinoma HPV PCR |
| url | https://www.mdpi.com/2072-6694/15/10/2722 |
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