Arsenic Trioxide Promotes Tumor Progression by Inducing the Formation of PGCCs and Embryonic Hemoglobin in Colon Cancer Cells

Arsenic Trioxide Promotes Tumor Progression by Inducing the Formation of PGCCs and Embryonic Hemoglobin in Colon Cancer Cells

Arsenic trioxide (ATO) has been used to treat acute promyelocytic leukemia. However, it is not effective in treating solid tumors such as colorectal cancer. We have previously reported that polyploid giant cancer cells (PGCCs) exhibiting the characteristics of cancer stem cells can be generated by v...

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Bibliographic Details
Main Authors: Zugui Li, Minying Zheng, Hao Zhang, Xiaohui Yang, Linlin Fan, Fangmei Fu, Junjie Fu, Rui Niu, Man Yan, Shiwu Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Oncology
Subjects:
arsenic trioxide
colon cancer
polyploid tumor giant cells
cell fusion
epithelial-mesenchymal transition
erythroid cell
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.720814/full

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