Disruption of Early or Late Epochs of Auditory Cortical Activity Impairs Speech Discrimination in Mice
Speech evokes robust activity in auditory cortex, which contains information over a wide range of spatial and temporal scales. It remains unclear which components of these neural representations are causally involved in the perception and processing of speech sounds. Here we compared the relative im...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.01394/full |
| _version_ | 1818067332743823360 |
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| author | Conor O’Sullivan Conor O’Sullivan Aldis P. Weible Michael Wehr Michael Wehr |
| author_facet | Conor O’Sullivan Conor O’Sullivan Aldis P. Weible Michael Wehr Michael Wehr |
| author_sort | Conor O’Sullivan |
| collection | DOAJ |
| description | Speech evokes robust activity in auditory cortex, which contains information over a wide range of spatial and temporal scales. It remains unclear which components of these neural representations are causally involved in the perception and processing of speech sounds. Here we compared the relative importance of early and late speech-evoked activity for consonant discrimination. We trained mice to discriminate the initial consonants in spoken words, and then tested the effect of optogenetically suppressing different temporal windows of speech-evoked activity in auditory cortex. We found that both early and late suppression disrupted performance equivalently. These results suggest that mice are impaired at recognizing either type of disrupted representation because it differs from those learned in training. |
| first_indexed | 2024-12-10T15:22:00Z |
| format | Article |
| id | doaj.art-ff0b1408c4274b238f79c344a2ec3ed5 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-10T15:22:00Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-ff0b1408c4274b238f79c344a2ec3ed52022-12-22T01:43:39ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-01-011310.3389/fnins.2019.01394497664Disruption of Early or Late Epochs of Auditory Cortical Activity Impairs Speech Discrimination in MiceConor O’Sullivan0Conor O’Sullivan1Aldis P. Weible2Michael Wehr3Michael Wehr4Institute of Neuroscience, University of Oregon, Eugene, OR, United StatesDepartment of Biology, University of Oregon, Eugene, OR, United StatesInstitute of Neuroscience, University of Oregon, Eugene, OR, United StatesInstitute of Neuroscience, University of Oregon, Eugene, OR, United StatesDepartment of Psychology, University of Oregon, Eugene, OR, United StatesSpeech evokes robust activity in auditory cortex, which contains information over a wide range of spatial and temporal scales. It remains unclear which components of these neural representations are causally involved in the perception and processing of speech sounds. Here we compared the relative importance of early and late speech-evoked activity for consonant discrimination. We trained mice to discriminate the initial consonants in spoken words, and then tested the effect of optogenetically suppressing different temporal windows of speech-evoked activity in auditory cortex. We found that both early and late suppression disrupted performance equivalently. These results suggest that mice are impaired at recognizing either type of disrupted representation because it differs from those learned in training.https://www.frontiersin.org/article/10.3389/fnins.2019.01394/fullconsonantspeech – brainspeech perceptiondiscriminationauditory cortexneural coding |
| spellingShingle | Conor O’Sullivan Conor O’Sullivan Aldis P. Weible Michael Wehr Michael Wehr Disruption of Early or Late Epochs of Auditory Cortical Activity Impairs Speech Discrimination in Mice Frontiers in Neuroscience consonant speech – brain speech perception discrimination auditory cortex neural coding |
| title | Disruption of Early or Late Epochs of Auditory Cortical Activity Impairs Speech Discrimination in Mice |
| title_full | Disruption of Early or Late Epochs of Auditory Cortical Activity Impairs Speech Discrimination in Mice |
| title_fullStr | Disruption of Early or Late Epochs of Auditory Cortical Activity Impairs Speech Discrimination in Mice |
| title_full_unstemmed | Disruption of Early or Late Epochs of Auditory Cortical Activity Impairs Speech Discrimination in Mice |
| title_short | Disruption of Early or Late Epochs of Auditory Cortical Activity Impairs Speech Discrimination in Mice |
| title_sort | disruption of early or late epochs of auditory cortical activity impairs speech discrimination in mice |
| topic | consonant speech – brain speech perception discrimination auditory cortex neural coding |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.01394/full |
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