A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.

A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.

Vascular endothelial growth factor A (VEGF-A) binds to the VEGFR2 receptor tyrosine kinase, regulating endothelial function, vascular physiology and angiogenesis. However, the mechanism underlying VEGFR2 turnover and degradation in this response is unclear. Here, we tested a role for heat-shock prot...

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Bibliographic Details
Main Authors: Alexander F Bruns, Nadira Yuldasheva, Antony M Latham, Leyuan Bao, Caroline Pellet-Many, Paul Frankel, Sam L Stephen, Gareth J Howell, Stephen B Wheatcroft, Mark T Kearney, Ian C Zachary, Sreenivasan Ponnambalam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3491040?pdf=render

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