Clinico-Hematological and cytogenetic spectrum of adult myelodysplastic syndrome: The first retrospective cross-sectional study in Iranian patients
Abstract Background Myelodysplastic syndrome (MDS), a heterogeneous group of hematopoietic malignancy, has been shown to present different cytogenetic abnormalities, risk factors, and clinico-hematological features in different populations and geographic areas. Herein, we determined the cytogenetic...
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | Molecular Cytogenetics |
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| Online Access: | https://doi.org/10.1186/s13039-021-00548-z |
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| author | Mostafa Paridar Kazem Zibara Seyed Esmaeil Ahmadi Abbas Khosravi Maral Soleymani Ebrahim Azizi Omid Kiani Ghalesardi |
| author_facet | Mostafa Paridar Kazem Zibara Seyed Esmaeil Ahmadi Abbas Khosravi Maral Soleymani Ebrahim Azizi Omid Kiani Ghalesardi |
| author_sort | Mostafa Paridar |
| collection | DOAJ |
| description | Abstract Background Myelodysplastic syndrome (MDS), a heterogeneous group of hematopoietic malignancy, has been shown to present different cytogenetic abnormalities, risk factors, and clinico-hematological features in different populations and geographic areas. Herein, we determined the cytogenetic spectrum and clinico-hematological features of Iranian MDS patients for the first time. Methods This prospective cross-sectional study was conducted on 103 patients with MDS in Ahvaz, southwest of Iran, from 2014 to 2018. Clinical presentations, complete blood counts (CBC), and bone marrow (BM) biopsy samples were assessed. Perls' staining was used to evaluate BM iron storage. The cytogenetic evaluation was performed using the conventional G banding method on the BM. Results Patients’ median age was 62.3 (ranged from 50–76), and the majority were male (72.8%). The most common clinical symptom at the time of admission was fatigue (n = 33) followed by pallor (n = 27). The most common subgroup was MDS-Multi Lineage Dysplasia (MDS-MLD) (n = 38, 36.8%), followed by MDS-Single Lineage Dysplasia (MDS-SLD) (n = 28, 18.4%). A normal karyotype was observed in 59 patients (57.3%), while 44 patients (42.7%) had cytogenetic abnormalities. Trisomy 8 (+ 8) was the most common cytogenetic abnormality (n = 14) followed by del 17p (n = 9) and monosomy 7 (− 7) (n = 7). Twelve patients (11.65%) were transformed to AML. Conclusion Our data betokened that among our MDS patients, Trisomy 8 is the predominant cytogenetic abnormality, and MDS-MLD and MDS-SLD are the most common of subtypes. Noteworthy, the male: female ratio was slightly higher in Iran than in previous reports from other parts of the world. Our study is the first report of the clinical, hematological, and cytogenetic spectrum of MDS patients in Iran |
| first_indexed | 2024-12-14T18:56:08Z |
| format | Article |
| id | doaj.art-ff0ca38f5bce415291fc598f6fa03dfd |
| institution | Directory Open Access Journal |
| issn | 1755-8166 |
| language | English |
| last_indexed | 2024-12-14T18:56:08Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cytogenetics |
| spelling | doaj.art-ff0ca38f5bce415291fc598f6fa03dfd2022-12-21T22:51:05ZengBMCMolecular Cytogenetics1755-81662021-05-011411710.1186/s13039-021-00548-zClinico-Hematological and cytogenetic spectrum of adult myelodysplastic syndrome: The first retrospective cross-sectional study in Iranian patientsMostafa Paridar0Kazem Zibara1Seyed Esmaeil Ahmadi2Abbas Khosravi3Maral Soleymani4Ebrahim Azizi5Omid Kiani Ghalesardi6Deputy of Education, Ministry of Health and Medical EducationPRASE, Biology Department, Faculty of Sciences-I, Lebanese UniversityDepartment of Hematology and Blood Banking, School of Allied Medicine, Iran University of Medical SciencesTransfusion Research Center, High Institute for Research and Education in Transfusion MedicineStudent Research Committee, Ahvaz Jundishapur University of Medical SciencesResearch Center for Thalassemia and Hemoglobinopathy, Health Institute, Ahvaz Jundishapur University of Medical SciencesDepartment of Hematology and Blood Banking, School of Allied Medicine, Iran University of Medical SciencesAbstract Background Myelodysplastic syndrome (MDS), a heterogeneous group of hematopoietic malignancy, has been shown to present different cytogenetic abnormalities, risk factors, and clinico-hematological features in different populations and geographic areas. Herein, we determined the cytogenetic spectrum and clinico-hematological features of Iranian MDS patients for the first time. Methods This prospective cross-sectional study was conducted on 103 patients with MDS in Ahvaz, southwest of Iran, from 2014 to 2018. Clinical presentations, complete blood counts (CBC), and bone marrow (BM) biopsy samples were assessed. Perls' staining was used to evaluate BM iron storage. The cytogenetic evaluation was performed using the conventional G banding method on the BM. Results Patients’ median age was 62.3 (ranged from 50–76), and the majority were male (72.8%). The most common clinical symptom at the time of admission was fatigue (n = 33) followed by pallor (n = 27). The most common subgroup was MDS-Multi Lineage Dysplasia (MDS-MLD) (n = 38, 36.8%), followed by MDS-Single Lineage Dysplasia (MDS-SLD) (n = 28, 18.4%). A normal karyotype was observed in 59 patients (57.3%), while 44 patients (42.7%) had cytogenetic abnormalities. Trisomy 8 (+ 8) was the most common cytogenetic abnormality (n = 14) followed by del 17p (n = 9) and monosomy 7 (− 7) (n = 7). Twelve patients (11.65%) were transformed to AML. Conclusion Our data betokened that among our MDS patients, Trisomy 8 is the predominant cytogenetic abnormality, and MDS-MLD and MDS-SLD are the most common of subtypes. Noteworthy, the male: female ratio was slightly higher in Iran than in previous reports from other parts of the world. Our study is the first report of the clinical, hematological, and cytogenetic spectrum of MDS patients in Iranhttps://doi.org/10.1186/s13039-021-00548-zMyelodysplastic syndromesHematological spectrumCytogeneticIran |
| spellingShingle | Mostafa Paridar Kazem Zibara Seyed Esmaeil Ahmadi Abbas Khosravi Maral Soleymani Ebrahim Azizi Omid Kiani Ghalesardi Clinico-Hematological and cytogenetic spectrum of adult myelodysplastic syndrome: The first retrospective cross-sectional study in Iranian patients Molecular Cytogenetics Myelodysplastic syndromes Hematological spectrum Cytogenetic Iran |
| title | Clinico-Hematological and cytogenetic spectrum of adult myelodysplastic syndrome: The first retrospective cross-sectional study in Iranian patients |
| title_full | Clinico-Hematological and cytogenetic spectrum of adult myelodysplastic syndrome: The first retrospective cross-sectional study in Iranian patients |
| title_fullStr | Clinico-Hematological and cytogenetic spectrum of adult myelodysplastic syndrome: The first retrospective cross-sectional study in Iranian patients |
| title_full_unstemmed | Clinico-Hematological and cytogenetic spectrum of adult myelodysplastic syndrome: The first retrospective cross-sectional study in Iranian patients |
| title_short | Clinico-Hematological and cytogenetic spectrum of adult myelodysplastic syndrome: The first retrospective cross-sectional study in Iranian patients |
| title_sort | clinico hematological and cytogenetic spectrum of adult myelodysplastic syndrome the first retrospective cross sectional study in iranian patients |
| topic | Myelodysplastic syndromes Hematological spectrum Cytogenetic Iran |
| url | https://doi.org/10.1186/s13039-021-00548-z |
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