HPV and vaginal microecological disorders in infertile women: a cross-sectional study in the Chinese population
Abstract Background The purpose of this study was to evaluate the distributions of vaginal microbiome dysbiosis and human papillomavirus (HPV) subtypes in infertile women and explore the correlations of HPV infection and vaginal microbiome dysbiosis with infertility. Methods In total, 1464 women age...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Virology Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12985-022-01869-0 |
| _version_ | 1828356715502895104 |
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| author | Li Wang Lin He Junyu Chen Shuyao Wei Hongzhou Xu Mengjun Luo |
| author_facet | Li Wang Lin He Junyu Chen Shuyao Wei Hongzhou Xu Mengjun Luo |
| author_sort | Li Wang |
| collection | DOAJ |
| description | Abstract Background The purpose of this study was to evaluate the distributions of vaginal microbiome dysbiosis and human papillomavirus (HPV) subtypes in infertile women and explore the correlations of HPV infection and vaginal microbiome dysbiosis with infertility. Methods In total, 1464 women aged 18–50 years were included in this study; 649 participants were included in the infertility group, and 815 participants were included in the normal group. The participants were tested for HPV, and their vaginal microecology was examined. The χ2 test and Spearman regression were used for statistical analysis, and binary logistic regression was performed to identify the risk factors for infertility. Results The patients in the infertility group were younger than those in the normal group, and the proportions of bacterial vaginosis and vaginal imbalance in the infertility group were significantly higher than those in the normal group. The incidence proportions of high-risk HPV types in the infertility group were significantly higher than those in the normal group, and the proportions of high-risk subtytes HPV16, HPV39, HV52, HPV56, and HPV68 were significantly higher in the infertility group than in the normal group. However, there were no significant differences in the incidences of low-risk HPV types. The incidence proportions of vaginal flora imbalance and HPV infection in the infertility group were significantly higher than those in the normal group. HPV16, HPV33, HPV51, HPV52and HPV58 infections were independent risk factors for infertility. Conclusions Vaginal microecological imbalance and HPV infection are directly related to infertility, and precautions should be taken. |
| first_indexed | 2024-04-14T03:03:16Z |
| format | Article |
| id | doaj.art-ff0f06f1a5804740b8578438196c4915 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-04-14T03:03:16Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-ff0f06f1a5804740b8578438196c49152022-12-22T02:15:50ZengBMCVirology Journal1743-422X2022-08-011911810.1186/s12985-022-01869-0HPV and vaginal microecological disorders in infertile women: a cross-sectional study in the Chinese populationLi Wang0Lin He1Junyu Chen2Shuyao Wei3Hongzhou Xu4Mengjun Luo5Department of Clinical Laboratory, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaDepartment of Clinical Laboratory, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaDepartment of Clinical Laboratory, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaDepartment of Clinical Laboratory, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaDepartment of Clinical Laboratory, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaDepartment of Clinical Laboratory, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaAbstract Background The purpose of this study was to evaluate the distributions of vaginal microbiome dysbiosis and human papillomavirus (HPV) subtypes in infertile women and explore the correlations of HPV infection and vaginal microbiome dysbiosis with infertility. Methods In total, 1464 women aged 18–50 years were included in this study; 649 participants were included in the infertility group, and 815 participants were included in the normal group. The participants were tested for HPV, and their vaginal microecology was examined. The χ2 test and Spearman regression were used for statistical analysis, and binary logistic regression was performed to identify the risk factors for infertility. Results The patients in the infertility group were younger than those in the normal group, and the proportions of bacterial vaginosis and vaginal imbalance in the infertility group were significantly higher than those in the normal group. The incidence proportions of high-risk HPV types in the infertility group were significantly higher than those in the normal group, and the proportions of high-risk subtytes HPV16, HPV39, HV52, HPV56, and HPV68 were significantly higher in the infertility group than in the normal group. However, there were no significant differences in the incidences of low-risk HPV types. The incidence proportions of vaginal flora imbalance and HPV infection in the infertility group were significantly higher than those in the normal group. HPV16, HPV33, HPV51, HPV52and HPV58 infections were independent risk factors for infertility. Conclusions Vaginal microecological imbalance and HPV infection are directly related to infertility, and precautions should be taken.https://doi.org/10.1186/s12985-022-01869-0InfertilityHuman papillomavirusVaginal microecological |
| spellingShingle | Li Wang Lin He Junyu Chen Shuyao Wei Hongzhou Xu Mengjun Luo HPV and vaginal microecological disorders in infertile women: a cross-sectional study in the Chinese population Virology Journal Infertility Human papillomavirus Vaginal microecological |
| title | HPV and vaginal microecological disorders in infertile women: a cross-sectional study in the Chinese population |
| title_full | HPV and vaginal microecological disorders in infertile women: a cross-sectional study in the Chinese population |
| title_fullStr | HPV and vaginal microecological disorders in infertile women: a cross-sectional study in the Chinese population |
| title_full_unstemmed | HPV and vaginal microecological disorders in infertile women: a cross-sectional study in the Chinese population |
| title_short | HPV and vaginal microecological disorders in infertile women: a cross-sectional study in the Chinese population |
| title_sort | hpv and vaginal microecological disorders in infertile women a cross sectional study in the chinese population |
| topic | Infertility Human papillomavirus Vaginal microecological |
| url | https://doi.org/10.1186/s12985-022-01869-0 |
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