Progression from prehypertension to hypertension and risk of cardiovascular disease
Background Subjects with prehypertension (pre-HT; 120/80 to 139/89 mm Hg) have an increased risk of cardiovascular disease (CVD); however, whether the risk of pre-HT can be seen at the pre-HT status or only after progression to a hypertensive (HT; ≥140/90 mm Hg) state during the follow-up period...
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| Format: | Article |
| Language: | English |
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Japan Epidemiological Association
2017-01-01
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| Series: | Journal of Epidemiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0917504016300442 |
| _version_ | 1818355300238884864 |
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| author | Yukiko Ishikawa |
| author_facet | Yukiko Ishikawa |
| author_sort | Yukiko Ishikawa |
| collection | DOAJ |
| description | Background
Subjects with prehypertension (pre-HT; 120/80 to 139/89 mm Hg) have an increased risk of cardiovascular disease (CVD); however, whether the risk of pre-HT can be seen at the pre-HT status or only after progression to a hypertensive (HT; ≥140/90 mm Hg) state during the follow-up period is unknown.
Methods
The Jichi Medical Cohort study enrolled 12,490 subjects recruited from a Japanese general population. Of those, 2227 subjects whose BP data at baseline and at the middle of follow-up and tracking of CVD events were available (median follow-up period: 11.8 years). We evaluated the risk of HT in those with normal BP or pre-HT at baseline whose BP progressed to HT at the middle of follow-up compared with those whose BP remained at normal or pre-HT levels.
Results
Among the 707 normotensive patients at baseline, 34.1% and 6.6% of subjects progressed to pre-HT and HT, respectively, by the middle of follow-up. Among 702 subjects with pre-HT at baseline, 26.1% progressed to HT. During the follow-up period, there were 11 CVD events in normotensive patients and 16 CVD events in pre-HT patients at baseline. The subjects who progressed from pre-HT to HT had 2.95 times higher risk of CVD than those who remained at normal BP or pre-HT in a multivariable-adjusted Cox hazard model.
Conclusion
This relatively long-term prospective cohort study indicated that the CVD risk with pre-HT might increase after progression to HT; however, the number of CVD events was small. Therefore, the results need to be confirmed in a larger cohort. |
| first_indexed | 2024-12-13T19:39:07Z |
| format | Article |
| id | doaj.art-ff0febaa4685470b93c562bf83525556 |
| institution | Directory Open Access Journal |
| issn | 0917-5040 1349-9092 |
| language | English |
| last_indexed | 2024-12-13T19:39:07Z |
| publishDate | 2017-01-01 |
| publisher | Japan Epidemiological Association |
| record_format | Article |
| series | Journal of Epidemiology |
| spelling | doaj.art-ff0febaa4685470b93c562bf835255562022-12-21T23:33:44ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922017-01-0127181310.1016/j.je.2016.08.001Progression from prehypertension to hypertension and risk of cardiovascular diseaseYukiko IshikawaBackground Subjects with prehypertension (pre-HT; 120/80 to 139/89 mm Hg) have an increased risk of cardiovascular disease (CVD); however, whether the risk of pre-HT can be seen at the pre-HT status or only after progression to a hypertensive (HT; ≥140/90 mm Hg) state during the follow-up period is unknown. Methods The Jichi Medical Cohort study enrolled 12,490 subjects recruited from a Japanese general population. Of those, 2227 subjects whose BP data at baseline and at the middle of follow-up and tracking of CVD events were available (median follow-up period: 11.8 years). We evaluated the risk of HT in those with normal BP or pre-HT at baseline whose BP progressed to HT at the middle of follow-up compared with those whose BP remained at normal or pre-HT levels. Results Among the 707 normotensive patients at baseline, 34.1% and 6.6% of subjects progressed to pre-HT and HT, respectively, by the middle of follow-up. Among 702 subjects with pre-HT at baseline, 26.1% progressed to HT. During the follow-up period, there were 11 CVD events in normotensive patients and 16 CVD events in pre-HT patients at baseline. The subjects who progressed from pre-HT to HT had 2.95 times higher risk of CVD than those who remained at normal BP or pre-HT in a multivariable-adjusted Cox hazard model. Conclusion This relatively long-term prospective cohort study indicated that the CVD risk with pre-HT might increase after progression to HT; however, the number of CVD events was small. Therefore, the results need to be confirmed in a larger cohort.http://www.sciencedirect.com/science/article/pii/S0917504016300442PrehypertensionJapaneseCardiovascular diseasePopulation-based study |
| spellingShingle | Yukiko Ishikawa Progression from prehypertension to hypertension and risk of cardiovascular disease Journal of Epidemiology Prehypertension Japanese Cardiovascular disease Population-based study |
| title | Progression from prehypertension to hypertension and risk of cardiovascular disease |
| title_full | Progression from prehypertension to hypertension and risk of cardiovascular disease |
| title_fullStr | Progression from prehypertension to hypertension and risk of cardiovascular disease |
| title_full_unstemmed | Progression from prehypertension to hypertension and risk of cardiovascular disease |
| title_short | Progression from prehypertension to hypertension and risk of cardiovascular disease |
| title_sort | progression from prehypertension to hypertension and risk of cardiovascular disease |
| topic | Prehypertension Japanese Cardiovascular disease Population-based study |
| url | http://www.sciencedirect.com/science/article/pii/S0917504016300442 |
| work_keys_str_mv | AT yukikoishikawa progressionfromprehypertensiontohypertensionandriskofcardiovasculardisease |