A tripartite synapse model in Drosophila.
Tripartite (three-part) synapses are defined by physical and functional interactions of glia with pre- and post-synaptic elements. Although tripartite synapses are thought to be of widespread importance in neurological health and disease, we are only beginning to develop an understanding of glial co...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-02-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21359186/pdf/?tool=EBI |
| _version_ | 1818845485416316928 |
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| author | Rie Danjo Fumiko Kawasaki Richard W Ordway |
| author_facet | Rie Danjo Fumiko Kawasaki Richard W Ordway |
| author_sort | Rie Danjo |
| collection | DOAJ |
| description | Tripartite (three-part) synapses are defined by physical and functional interactions of glia with pre- and post-synaptic elements. Although tripartite synapses are thought to be of widespread importance in neurological health and disease, we are only beginning to develop an understanding of glial contributions to synaptic function. In contrast to studies of neuronal mechanisms, a significant limitation has been the lack of an invertebrate genetic model system in which conserved mechanisms of tripartite synapse function may be examined through large-scale application of forward genetics and genome-wide genetic tools. Here we report a Drosophila tripartite synapse model which exhibits morphological and functional properties similar to those of mammalian synapses, including glial regulation of extracellular glutamate, synaptically-induced glial calcium transients and glial coupling of synapses with tracheal structures mediating gas exchange. In combination with classical and cell-type specific genetic approaches in Drosophila, this model is expected to provide new insights into the molecular and cellular mechanisms of tripartite synapse function. |
| first_indexed | 2024-12-19T05:30:24Z |
| format | Article |
| id | doaj.art-ff101e9e0f6c48d8ba654e01bd9da65d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T05:30:24Z |
| publishDate | 2011-02-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ff101e9e0f6c48d8ba654e01bd9da65d2022-12-21T20:34:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-02-0162e1713110.1371/journal.pone.0017131A tripartite synapse model in Drosophila.Rie DanjoFumiko KawasakiRichard W OrdwayTripartite (three-part) synapses are defined by physical and functional interactions of glia with pre- and post-synaptic elements. Although tripartite synapses are thought to be of widespread importance in neurological health and disease, we are only beginning to develop an understanding of glial contributions to synaptic function. In contrast to studies of neuronal mechanisms, a significant limitation has been the lack of an invertebrate genetic model system in which conserved mechanisms of tripartite synapse function may be examined through large-scale application of forward genetics and genome-wide genetic tools. Here we report a Drosophila tripartite synapse model which exhibits morphological and functional properties similar to those of mammalian synapses, including glial regulation of extracellular glutamate, synaptically-induced glial calcium transients and glial coupling of synapses with tracheal structures mediating gas exchange. In combination with classical and cell-type specific genetic approaches in Drosophila, this model is expected to provide new insights into the molecular and cellular mechanisms of tripartite synapse function.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21359186/pdf/?tool=EBI |
| spellingShingle | Rie Danjo Fumiko Kawasaki Richard W Ordway A tripartite synapse model in Drosophila. PLoS ONE |
| title | A tripartite synapse model in Drosophila. |
| title_full | A tripartite synapse model in Drosophila. |
| title_fullStr | A tripartite synapse model in Drosophila. |
| title_full_unstemmed | A tripartite synapse model in Drosophila. |
| title_short | A tripartite synapse model in Drosophila. |
| title_sort | tripartite synapse model in drosophila |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21359186/pdf/?tool=EBI |
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