A Double-Edged Sword: The Two Faces of PARylation
Poly ADP-ribosylation (PARylation) is a post-translational modification process. Following the discovery of PARP-1, numerous studies have demonstrated the role of PARylation in the DNA damage and repair responses for cellular stress and DNA damage. Originally, studies on PARylation were confined to...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/17/9826 |
| _version_ | 1797495227417624576 |
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| author | Mincheol Kang Seojin Park Seong-Hoon Park Hee Gu Lee Jun Hong Park |
| author_facet | Mincheol Kang Seojin Park Seong-Hoon Park Hee Gu Lee Jun Hong Park |
| author_sort | Mincheol Kang |
| collection | DOAJ |
| description | Poly ADP-ribosylation (PARylation) is a post-translational modification process. Following the discovery of PARP-1, numerous studies have demonstrated the role of PARylation in the DNA damage and repair responses for cellular stress and DNA damage. Originally, studies on PARylation were confined to PARP-1 activation in the DNA repair pathway. However, the interplay between PARylation and DNA repair suggests that PARylation is important for the efficiency and accuracy of DNA repair. PARylation has contradicting roles; however, recent evidence implicates its importance in inflammation, metabolism, and cell death. These differences might be dependent on specific cellular conditions or experimental models used, and suggest that PARylation may play two opposing roles in cellular homeostasis. Understanding the role of PARylation in cellular function is not only important for identifying novel therapeutic approaches; it is also essential for gaining insight into the mechanisms of unexplored diseases. In this review, we discuss recent reports on the role of PARylation in mediating diverse cellular functions and homeostasis, such as DNA repair, inflammation, metabolism, and cell death. |
| first_indexed | 2024-03-10T01:44:48Z |
| format | Article |
| id | doaj.art-ff10707238094de99c7677aacdff3aaf |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:44:48Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ff10707238094de99c7677aacdff3aaf2023-11-23T13:17:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012317982610.3390/ijms23179826A Double-Edged Sword: The Two Faces of PARylationMincheol Kang0Seojin Park1Seong-Hoon Park2Hee Gu Lee3Jun Hong Park4Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju-si 58245, KoreaHerbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju-si 58245, KoreaGenetic and Epigenetic Toxicology Research Group, Korea Institute of Toxicology, Daejeon 34141, KoreaImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, KoreaHerbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju-si 58245, KoreaPoly ADP-ribosylation (PARylation) is a post-translational modification process. Following the discovery of PARP-1, numerous studies have demonstrated the role of PARylation in the DNA damage and repair responses for cellular stress and DNA damage. Originally, studies on PARylation were confined to PARP-1 activation in the DNA repair pathway. However, the interplay between PARylation and DNA repair suggests that PARylation is important for the efficiency and accuracy of DNA repair. PARylation has contradicting roles; however, recent evidence implicates its importance in inflammation, metabolism, and cell death. These differences might be dependent on specific cellular conditions or experimental models used, and suggest that PARylation may play two opposing roles in cellular homeostasis. Understanding the role of PARylation in cellular function is not only important for identifying novel therapeutic approaches; it is also essential for gaining insight into the mechanisms of unexplored diseases. In this review, we discuss recent reports on the role of PARylation in mediating diverse cellular functions and homeostasis, such as DNA repair, inflammation, metabolism, and cell death.https://www.mdpi.com/1422-0067/23/17/9826PARylationpoly(ADP-ribose) polymerases (PARPs)ADP-riboseNAD<sup>+</sup>protein post-translational modifications |
| spellingShingle | Mincheol Kang Seojin Park Seong-Hoon Park Hee Gu Lee Jun Hong Park A Double-Edged Sword: The Two Faces of PARylation International Journal of Molecular Sciences PARylation poly(ADP-ribose) polymerases (PARPs) ADP-ribose NAD<sup>+</sup> protein post-translational modifications |
| title | A Double-Edged Sword: The Two Faces of PARylation |
| title_full | A Double-Edged Sword: The Two Faces of PARylation |
| title_fullStr | A Double-Edged Sword: The Two Faces of PARylation |
| title_full_unstemmed | A Double-Edged Sword: The Two Faces of PARylation |
| title_short | A Double-Edged Sword: The Two Faces of PARylation |
| title_sort | double edged sword the two faces of parylation |
| topic | PARylation poly(ADP-ribose) polymerases (PARPs) ADP-ribose NAD<sup>+</sup> protein post-translational modifications |
| url | https://www.mdpi.com/1422-0067/23/17/9826 |
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