In Vitro Antioxidant Activity and In Vivo Topical Efficacy of Lipid Nanoparticles Co-Loading Idebenone and Tocopheryl Acetate

In Vitro Antioxidant Activity and In Vivo Topical Efficacy of Lipid Nanoparticles Co-Loading Idebenone and Tocopheryl Acetate

Idebenone (IDE) is a strong antioxidant that has been proposed for the treatment of skin disorders, including skin ageing. Unfavorable physico-chemical properties make IDE a poor skin permeant where effectiveness could be improved by its loading into suitable delivery systems such as solid lipid nan...

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Bibliographic Details
Main Authors: Lucia Montenegro, Concetta Maria Messina, Simona Manuguerra, Ludovica Maria Santagati, Lorella Pasquinucci, Rita Turnaturi, Carmela Parenti, Rosaria Arena, Andrea Santulli
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Applied Sciences
Subjects:
Idebenone
tocopheryl acetate
lipid nanoparticles
antioxidants
topical administration
skin hydration
photo-protective effect
Online Access:https://www.mdpi.com/2076-3417/9/5/845

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