The remodeling of ovarian function: targeted delivery strategies for mesenchymal stem cells and their derived extracellular vesicles
Abstract Premature ovarian insufficiency (POI) is an essential cause of reduced fertility and quality of life in young women. Mesenchymal stem cells (MSCs) and MSCs-derived extracellular vesicles (EVs) have the ability to migrate to damaged tissues and are considered as promising therapeutic approac...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-024-03704-5 |
| _version_ | 1827301363889995776 |
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| author | Yinhua Song Jiachen Wu Yang Liu Na Xu Hualin Bai Lingjuan Wang Jihui Ai Kezhen Li |
| author_facet | Yinhua Song Jiachen Wu Yang Liu Na Xu Hualin Bai Lingjuan Wang Jihui Ai Kezhen Li |
| author_sort | Yinhua Song |
| collection | DOAJ |
| description | Abstract Premature ovarian insufficiency (POI) is an essential cause of reduced fertility and quality of life in young women. Mesenchymal stem cells (MSCs) and MSCs-derived extracellular vesicles (EVs) have the ability to migrate to damaged tissues and are considered as promising therapeutic approaches for POI. However, the homing ability and therapeutic efficacy of MSCs administered in vivo are still insufficient, and their potential tumorigenicity and multi-differentiation potential also bring many doubts about their safety. The targeting ability and migration efficiency of MSCs can be improved by genetic engineering and surface modification, thereby maximizing their therapeutic efficacy. However, the use of viral vectors also has increased safety concerns. In addition, EVs, which seem to be the current therapeutic alternative to MSCs, are still poorly targeted for distribution, although they have improved in terms of safety. This paper reviews the comparative therapeutic effects of MSCs and their derived EVs on POI, their biodistribution after in vivo administration, and the most important possible ovarian targeting strategies. Difficulties such as homogeneity and yield before clinical application are also discussed. This article will provide new insights into precision therapy and targeted drug delivery for female ovarian diseases. Graphical Abstract |
| first_indexed | 2024-04-24T16:21:53Z |
| format | Article |
| id | doaj.art-ff12e505507f44f58d84dee1a0d62bb4 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-04-24T16:21:53Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-ff12e505507f44f58d84dee1a0d62bb42024-03-31T11:12:04ZengBMCStem Cell Research & Therapy1757-65122024-03-0115111810.1186/s13287-024-03704-5The remodeling of ovarian function: targeted delivery strategies for mesenchymal stem cells and their derived extracellular vesiclesYinhua Song0Jiachen Wu1Yang Liu2Na Xu3Hualin Bai4Lingjuan Wang5Jihui Ai6Kezhen Li7Department of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyNational Clinical Research Center for Obstetrics and Gynecology, Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyReproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Premature ovarian insufficiency (POI) is an essential cause of reduced fertility and quality of life in young women. Mesenchymal stem cells (MSCs) and MSCs-derived extracellular vesicles (EVs) have the ability to migrate to damaged tissues and are considered as promising therapeutic approaches for POI. However, the homing ability and therapeutic efficacy of MSCs administered in vivo are still insufficient, and their potential tumorigenicity and multi-differentiation potential also bring many doubts about their safety. The targeting ability and migration efficiency of MSCs can be improved by genetic engineering and surface modification, thereby maximizing their therapeutic efficacy. However, the use of viral vectors also has increased safety concerns. In addition, EVs, which seem to be the current therapeutic alternative to MSCs, are still poorly targeted for distribution, although they have improved in terms of safety. This paper reviews the comparative therapeutic effects of MSCs and their derived EVs on POI, their biodistribution after in vivo administration, and the most important possible ovarian targeting strategies. Difficulties such as homogeneity and yield before clinical application are also discussed. This article will provide new insights into precision therapy and targeted drug delivery for female ovarian diseases. Graphical Abstracthttps://doi.org/10.1186/s13287-024-03704-5Mesenchymal stem cellsExtracellular vesiclesPremature ovarian insufficiencyTargeted delivery |
| spellingShingle | Yinhua Song Jiachen Wu Yang Liu Na Xu Hualin Bai Lingjuan Wang Jihui Ai Kezhen Li The remodeling of ovarian function: targeted delivery strategies for mesenchymal stem cells and their derived extracellular vesicles Stem Cell Research & Therapy Mesenchymal stem cells Extracellular vesicles Premature ovarian insufficiency Targeted delivery |
| title | The remodeling of ovarian function: targeted delivery strategies for mesenchymal stem cells and their derived extracellular vesicles |
| title_full | The remodeling of ovarian function: targeted delivery strategies for mesenchymal stem cells and their derived extracellular vesicles |
| title_fullStr | The remodeling of ovarian function: targeted delivery strategies for mesenchymal stem cells and their derived extracellular vesicles |
| title_full_unstemmed | The remodeling of ovarian function: targeted delivery strategies for mesenchymal stem cells and their derived extracellular vesicles |
| title_short | The remodeling of ovarian function: targeted delivery strategies for mesenchymal stem cells and their derived extracellular vesicles |
| title_sort | remodeling of ovarian function targeted delivery strategies for mesenchymal stem cells and their derived extracellular vesicles |
| topic | Mesenchymal stem cells Extracellular vesicles Premature ovarian insufficiency Targeted delivery |
| url | https://doi.org/10.1186/s13287-024-03704-5 |
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