Seroprevalence of high incidence congenital infections among pregnant women in Coatepeque, Guatemala and surrounding areas, 2017-2018.
Maternal infections during pregnancy can potentially cause birth defects and severe adverse effects in infants. From 2017 to 2018, we investigated the seroprevalence of five antibodies among 436 mother-infant pairs enrolled in a pregnancy cohort study in Coatepeque, Guatemala. Upon enrollment (<...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-04-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0011248 |
| _version_ | 1797826321459445760 |
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| author | Victoria J Hicks César Sánchez María Reneé López Anna Gottschlich Laura M Grajeda Amanda Balish Ana Gómez Nevis Nuñez Julio Juárez Beatriz López Mariangeli Freitas-Ning Celia Cordón-Rosales Manuel Sagastume John P McCracken Andrés Espinosa-Bode Loren Cadena Terrence Q Lo |
| author_facet | Victoria J Hicks César Sánchez María Reneé López Anna Gottschlich Laura M Grajeda Amanda Balish Ana Gómez Nevis Nuñez Julio Juárez Beatriz López Mariangeli Freitas-Ning Celia Cordón-Rosales Manuel Sagastume John P McCracken Andrés Espinosa-Bode Loren Cadena Terrence Q Lo |
| author_sort | Victoria J Hicks |
| collection | DOAJ |
| description | Maternal infections during pregnancy can potentially cause birth defects and severe adverse effects in infants. From 2017 to 2018, we investigated the seroprevalence of five antibodies among 436 mother-infant pairs enrolled in a pregnancy cohort study in Coatepeque, Guatemala. Upon enrollment (< 20 weeks gestational age) and shortly after delivery, we measured the prevalence of IgG and IgM antibodies against Toxoplasma gondii (T. gondii), rubella, and cytomegalovirus (CMV) in mothers and newborns and used rapid tests to detect HIV and syphilis (Treponema pallidum) in mothers. The mean cohort age was 24.5 years. Maternal T. gondii IgM and IgG seropositivity was 1.9% and 69.7%, respectively. No women were positive for HIV, syphilis, or rubella IgM. Maternal rubella IgG seropositivity was 80.8% and significantly increased with age. Maternal CMV IgM and IgG seropositivity were 2.3% and 99.5%, respectively. Of the 323 women tested at both timepoints, IgM reactivation occurred in one woman for T. gondii infection and in eight for CMV. No newborn was seropositive for CMV IgM or rubella IgM. One newborn was seropositive for T. gondii IgM. Congenital T. gondii and CMV infections are important public health issues for pregnant women, newborns, and healthcare providers in Coatepeque and Guatemala. |
| first_indexed | 2024-03-13T11:07:03Z |
| format | Article |
| id | doaj.art-ff133135991e4ba08601dc2d7cfda8f1 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-03-13T11:07:03Z |
| publishDate | 2023-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-ff133135991e4ba08601dc2d7cfda8f12023-05-16T05:31:07ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352023-04-01174e001124810.1371/journal.pntd.0011248Seroprevalence of high incidence congenital infections among pregnant women in Coatepeque, Guatemala and surrounding areas, 2017-2018.Victoria J HicksCésar SánchezMaría Reneé LópezAnna GottschlichLaura M GrajedaAmanda BalishAna GómezNevis NuñezJulio JuárezBeatriz LópezMariangeli Freitas-NingCelia Cordón-RosalesManuel SagastumeJohn P McCrackenAndrés Espinosa-BodeLoren CadenaTerrence Q LoMaternal infections during pregnancy can potentially cause birth defects and severe adverse effects in infants. From 2017 to 2018, we investigated the seroprevalence of five antibodies among 436 mother-infant pairs enrolled in a pregnancy cohort study in Coatepeque, Guatemala. Upon enrollment (< 20 weeks gestational age) and shortly after delivery, we measured the prevalence of IgG and IgM antibodies against Toxoplasma gondii (T. gondii), rubella, and cytomegalovirus (CMV) in mothers and newborns and used rapid tests to detect HIV and syphilis (Treponema pallidum) in mothers. The mean cohort age was 24.5 years. Maternal T. gondii IgM and IgG seropositivity was 1.9% and 69.7%, respectively. No women were positive for HIV, syphilis, or rubella IgM. Maternal rubella IgG seropositivity was 80.8% and significantly increased with age. Maternal CMV IgM and IgG seropositivity were 2.3% and 99.5%, respectively. Of the 323 women tested at both timepoints, IgM reactivation occurred in one woman for T. gondii infection and in eight for CMV. No newborn was seropositive for CMV IgM or rubella IgM. One newborn was seropositive for T. gondii IgM. Congenital T. gondii and CMV infections are important public health issues for pregnant women, newborns, and healthcare providers in Coatepeque and Guatemala.https://doi.org/10.1371/journal.pntd.0011248 |
| spellingShingle | Victoria J Hicks César Sánchez María Reneé López Anna Gottschlich Laura M Grajeda Amanda Balish Ana Gómez Nevis Nuñez Julio Juárez Beatriz López Mariangeli Freitas-Ning Celia Cordón-Rosales Manuel Sagastume John P McCracken Andrés Espinosa-Bode Loren Cadena Terrence Q Lo Seroprevalence of high incidence congenital infections among pregnant women in Coatepeque, Guatemala and surrounding areas, 2017-2018. PLoS Neglected Tropical Diseases |
| title | Seroprevalence of high incidence congenital infections among pregnant women in Coatepeque, Guatemala and surrounding areas, 2017-2018. |
| title_full | Seroprevalence of high incidence congenital infections among pregnant women in Coatepeque, Guatemala and surrounding areas, 2017-2018. |
| title_fullStr | Seroprevalence of high incidence congenital infections among pregnant women in Coatepeque, Guatemala and surrounding areas, 2017-2018. |
| title_full_unstemmed | Seroprevalence of high incidence congenital infections among pregnant women in Coatepeque, Guatemala and surrounding areas, 2017-2018. |
| title_short | Seroprevalence of high incidence congenital infections among pregnant women in Coatepeque, Guatemala and surrounding areas, 2017-2018. |
| title_sort | seroprevalence of high incidence congenital infections among pregnant women in coatepeque guatemala and surrounding areas 2017 2018 |
| url | https://doi.org/10.1371/journal.pntd.0011248 |
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