Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection
Coxsackievirus B3 (CVB3) infections may cause life-threatening diseases and have no approved specific treatment. Some promising approaches to treat viral diseases include drug repurposing and combination therapy. We have selected in this study dasabuvir, an approved antiviral drug, and PSI-6206, an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Journal of Virus Eradication |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2055664022000127 |
| _version_ | 1811325633111785472 |
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| author | Oluwatayo Israel Olasunkanmi Zhao-Hua Zhong |
| author_facet | Oluwatayo Israel Olasunkanmi Zhao-Hua Zhong |
| author_sort | Oluwatayo Israel Olasunkanmi |
| collection | DOAJ |
| description | Coxsackievirus B3 (CVB3) infections may cause life-threatening diseases and have no approved specific treatment. Some promising approaches to treat viral diseases include drug repurposing and combination therapy. We have selected in this study dasabuvir, an approved antiviral drug, and PSI-6206, an experimental drug and determined their individual and combined antiviral activity against CVB3 replication in vitro. Our results show that the individual drugs inhibited CVB3 infection in a dose-dependent manner, at a selective index >10 with a strong synergetic antiviral effect of the two compounds. Given that dasabuvir has already been approved for the treatment of hepatitis C virus infection, treatment of CVB3-related disease with this drug may represent a promising treatment strategy. |
| first_indexed | 2024-04-13T14:36:36Z |
| format | Article |
| id | doaj.art-ff14578c21684ebab826fa9868ffeef7 |
| institution | Directory Open Access Journal |
| issn | 2055-6640 |
| language | English |
| last_indexed | 2024-04-13T14:36:36Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Virus Eradication |
| spelling | doaj.art-ff14578c21684ebab826fa9868ffeef72022-12-22T02:43:02ZengElsevierJournal of Virus Eradication2055-66402022-06-0182100074Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infectionOluwatayo Israel Olasunkanmi0Zhao-Hua Zhong1Department of Microbiology, Harbin Medical University, Harbin, 150081, ChinaCorresponding author.; Department of Microbiology, Harbin Medical University, Harbin, 150081, ChinaCoxsackievirus B3 (CVB3) infections may cause life-threatening diseases and have no approved specific treatment. Some promising approaches to treat viral diseases include drug repurposing and combination therapy. We have selected in this study dasabuvir, an approved antiviral drug, and PSI-6206, an experimental drug and determined their individual and combined antiviral activity against CVB3 replication in vitro. Our results show that the individual drugs inhibited CVB3 infection in a dose-dependent manner, at a selective index >10 with a strong synergetic antiviral effect of the two compounds. Given that dasabuvir has already been approved for the treatment of hepatitis C virus infection, treatment of CVB3-related disease with this drug may represent a promising treatment strategy.http://www.sciencedirect.com/science/article/pii/S2055664022000127Coxsackievirus B3DasabuvirPSI-6206Drug repurposingDrug combination |
| spellingShingle | Oluwatayo Israel Olasunkanmi Zhao-Hua Zhong Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection Journal of Virus Eradication Coxsackievirus B3 Dasabuvir PSI-6206 Drug repurposing Drug combination |
| title | Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection |
| title_full | Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection |
| title_fullStr | Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection |
| title_full_unstemmed | Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection |
| title_short | Combination of dasabuvir and PSI-6206 for the treatment of coxsackievirus B3 infection |
| title_sort | combination of dasabuvir and psi 6206 for the treatment of coxsackievirus b3 infection |
| topic | Coxsackievirus B3 Dasabuvir PSI-6206 Drug repurposing Drug combination |
| url | http://www.sciencedirect.com/science/article/pii/S2055664022000127 |
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