Desensitization Protocols for Anti-SARS-CoV-2 Vaccines in Patients with High Risk of Allergic Reactions
Vaccines for SAR-CoV-2 are the most effective preventive treatment able to reduce the risk of contracting the infection and experiencing worse outcomes whenever the infection is contracted. Despite their rarity, hypersensitivity reactions to the anti-SARS-CoV-2 vaccine have been described and could...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/11/5/910 |
| _version_ | 1827740010480140288 |
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| author | Maria Rita Messina Carlotta Crisciotti Laura Pellegrini Emanuele Nappi Francesca Racca Giovanni Costanzo Lorenzo Del Moro Sebastian Ferri Francesca Puggioni Giorgio Walter Canonica Enrico Heffler Giovanni Paoletti |
| author_facet | Maria Rita Messina Carlotta Crisciotti Laura Pellegrini Emanuele Nappi Francesca Racca Giovanni Costanzo Lorenzo Del Moro Sebastian Ferri Francesca Puggioni Giorgio Walter Canonica Enrico Heffler Giovanni Paoletti |
| author_sort | Maria Rita Messina |
| collection | DOAJ |
| description | Vaccines for SAR-CoV-2 are the most effective preventive treatment able to reduce the risk of contracting the infection and experiencing worse outcomes whenever the infection is contracted. Despite their rarity, hypersensitivity reactions to the anti-SARS-CoV-2 vaccine have been described and could become the reason not to complete the vaccination. Desensitization protocols for other vaccines have been described and validated, while the use of this approach for anti-SARS-CoV-2 vaccines is still anecdotal. We herein describe our experience with 30 patients with previous allergic reactions to anti-SARS-CoV-2 vaccines or to any of their excipients, proving that they are effective and safe; only two patients experienced hypersensitivity reaction symptoms during the desensitization procedure. Moreover, in this article, we propose desensitization protocols for the most common anti-SARS-CoV-2 vaccines. |
| first_indexed | 2024-03-11T03:15:59Z |
| format | Article |
| id | doaj.art-ff15a88252284938a481c2e491e9f6ac |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T03:15:59Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-ff15a88252284938a481c2e491e9f6ac2023-11-18T03:35:35ZengMDPI AGVaccines2076-393X2023-04-0111591010.3390/vaccines11050910Desensitization Protocols for Anti-SARS-CoV-2 Vaccines in Patients with High Risk of Allergic ReactionsMaria Rita Messina0Carlotta Crisciotti1Laura Pellegrini2Emanuele Nappi3Francesca Racca4Giovanni Costanzo5Lorenzo Del Moro6Sebastian Ferri7Francesca Puggioni8Giorgio Walter Canonica9Enrico Heffler10Giovanni Paoletti11Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyVaccines for SAR-CoV-2 are the most effective preventive treatment able to reduce the risk of contracting the infection and experiencing worse outcomes whenever the infection is contracted. Despite their rarity, hypersensitivity reactions to the anti-SARS-CoV-2 vaccine have been described and could become the reason not to complete the vaccination. Desensitization protocols for other vaccines have been described and validated, while the use of this approach for anti-SARS-CoV-2 vaccines is still anecdotal. We herein describe our experience with 30 patients with previous allergic reactions to anti-SARS-CoV-2 vaccines or to any of their excipients, proving that they are effective and safe; only two patients experienced hypersensitivity reaction symptoms during the desensitization procedure. Moreover, in this article, we propose desensitization protocols for the most common anti-SARS-CoV-2 vaccines.https://www.mdpi.com/2076-393X/11/5/910SARS-CoV-2COVID-19vaccineallergydesensitization |
| spellingShingle | Maria Rita Messina Carlotta Crisciotti Laura Pellegrini Emanuele Nappi Francesca Racca Giovanni Costanzo Lorenzo Del Moro Sebastian Ferri Francesca Puggioni Giorgio Walter Canonica Enrico Heffler Giovanni Paoletti Desensitization Protocols for Anti-SARS-CoV-2 Vaccines in Patients with High Risk of Allergic Reactions Vaccines SARS-CoV-2 COVID-19 vaccine allergy desensitization |
| title | Desensitization Protocols for Anti-SARS-CoV-2 Vaccines in Patients with High Risk of Allergic Reactions |
| title_full | Desensitization Protocols for Anti-SARS-CoV-2 Vaccines in Patients with High Risk of Allergic Reactions |
| title_fullStr | Desensitization Protocols for Anti-SARS-CoV-2 Vaccines in Patients with High Risk of Allergic Reactions |
| title_full_unstemmed | Desensitization Protocols for Anti-SARS-CoV-2 Vaccines in Patients with High Risk of Allergic Reactions |
| title_short | Desensitization Protocols for Anti-SARS-CoV-2 Vaccines in Patients with High Risk of Allergic Reactions |
| title_sort | desensitization protocols for anti sars cov 2 vaccines in patients with high risk of allergic reactions |
| topic | SARS-CoV-2 COVID-19 vaccine allergy desensitization |
| url | https://www.mdpi.com/2076-393X/11/5/910 |
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