Cardiovascular disease and risk of lung cancer incidence and mortality: A nationwide matched cohort study
PurposePrevious studies have suggested a link between cardiovascular disease (CVD) and the subsequent development of lung cancer. However, empirical evidence on the association of CVDs, particularly type-specific CVDs, with lung cancer incidence and survival remains limited.MethodsThe cohort study i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.950971/full |
| _version_ | 1828177881105170432 |
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| author | Ce Wang Donghao Lu Donghao Lu Deirdre Cronin-Fenton Chen Huang Zeyan Liew Dang Wei Guoyou Qin Yongfu Yu Yongfu Yu Jiong Li |
| author_facet | Ce Wang Donghao Lu Donghao Lu Deirdre Cronin-Fenton Chen Huang Zeyan Liew Dang Wei Guoyou Qin Yongfu Yu Yongfu Yu Jiong Li |
| author_sort | Ce Wang |
| collection | DOAJ |
| description | PurposePrevious studies have suggested a link between cardiovascular disease (CVD) and the subsequent development of lung cancer. However, empirical evidence on the association of CVDs, particularly type-specific CVDs, with lung cancer incidence and survival remains limited.MethodsThe cohort study included 306,285 patients with CVD and 1,222,140 individuals without CVD. We performed stratified Cox regression to estimate the hazard ratio (HR).ResultsDuring up to 42 years of follow-up, 243 (0.08%) and 537 (0.04%) participants were diagnosed with lung cancer among CVD patients and matched individuals, respectively. Patients with CVD had a 67% increased risk of lung cancer (HR: 1.67, 95% confidence interval [CI]: 1.42–1.96). The increased risks were observed in patients with heart disease (1.93, 1.30–2.85), vascular disease (1.88, 1.35–2.61), and hypertensive disease (1.46, 1.15–1.85), respectively. Patients with CVD had a 95% increased risk of lung cancer mortality (1.95, 1.50–2.55), particularly vascular disease (3.24, 1.74–6.02) and heart disease (2.29, 1.23–4.26). Patients with CVD diagnosed in middle adulthood (>40 years old) tended to have a higher incidence risk (3.44, 2.28–5.19) and mortality (3.67, 1.80–7.46) than those diagnosed at younger ages.ConclusionsOur findings on the association of CVD diagnosis, especially heart and vascular disease, with increased risk of lung cancer incidence and mortality suggest that CVD contributes to the development and worsening of lung cancer survival. In particular, people with CVD diagnosed in middle adulthood (>40 years old) would benefit from early preventive evaluation and screening for lung cancer. |
| first_indexed | 2024-04-12T05:05:33Z |
| format | Article |
| id | doaj.art-ff1642e1dfc54e2dbc09aa1b40705797 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T05:05:33Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ff1642e1dfc54e2dbc09aa1b407057972022-12-22T03:46:54ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.950971950971Cardiovascular disease and risk of lung cancer incidence and mortality: A nationwide matched cohort studyCe Wang0Donghao Lu1Donghao Lu2Deirdre Cronin-Fenton3Chen Huang4Zeyan Liew5Dang Wei6Guoyou Qin7Yongfu Yu8Yongfu Yu9Jiong Li10Department of Biostatistics, School of Public Health, The Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, ChinaUnit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, United StatesDepartment of Clinical Medicine–Department of Clinical Epidemiology, Aarhus University, Aarhus, DenmarkDepartment of Biostatistics, School of Public Health, The Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, ChinaDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, United StatesDepartment of Global Public Health, Karolinska Institutet, Stockholm, SwedenShanghai Institute of Infectious Disease and Biosecurity, Shanghai, ChinaDepartment of Biostatistics, School of Public Health, The Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, ChinaShanghai Institute of Infectious Disease and Biosecurity, Shanghai, ChinaDepartment of Clinical Medicine–Department of Clinical Epidemiology, Aarhus University, Aarhus, DenmarkPurposePrevious studies have suggested a link between cardiovascular disease (CVD) and the subsequent development of lung cancer. However, empirical evidence on the association of CVDs, particularly type-specific CVDs, with lung cancer incidence and survival remains limited.MethodsThe cohort study included 306,285 patients with CVD and 1,222,140 individuals without CVD. We performed stratified Cox regression to estimate the hazard ratio (HR).ResultsDuring up to 42 years of follow-up, 243 (0.08%) and 537 (0.04%) participants were diagnosed with lung cancer among CVD patients and matched individuals, respectively. Patients with CVD had a 67% increased risk of lung cancer (HR: 1.67, 95% confidence interval [CI]: 1.42–1.96). The increased risks were observed in patients with heart disease (1.93, 1.30–2.85), vascular disease (1.88, 1.35–2.61), and hypertensive disease (1.46, 1.15–1.85), respectively. Patients with CVD had a 95% increased risk of lung cancer mortality (1.95, 1.50–2.55), particularly vascular disease (3.24, 1.74–6.02) and heart disease (2.29, 1.23–4.26). Patients with CVD diagnosed in middle adulthood (>40 years old) tended to have a higher incidence risk (3.44, 2.28–5.19) and mortality (3.67, 1.80–7.46) than those diagnosed at younger ages.ConclusionsOur findings on the association of CVD diagnosis, especially heart and vascular disease, with increased risk of lung cancer incidence and mortality suggest that CVD contributes to the development and worsening of lung cancer survival. In particular, people with CVD diagnosed in middle adulthood (>40 years old) would benefit from early preventive evaluation and screening for lung cancer.https://www.frontiersin.org/articles/10.3389/fonc.2022.950971/fullcardiovascular diseaselung cancerincidencemortalitysurvival |
| spellingShingle | Ce Wang Donghao Lu Donghao Lu Deirdre Cronin-Fenton Chen Huang Zeyan Liew Dang Wei Guoyou Qin Yongfu Yu Yongfu Yu Jiong Li Cardiovascular disease and risk of lung cancer incidence and mortality: A nationwide matched cohort study Frontiers in Oncology cardiovascular disease lung cancer incidence mortality survival |
| title | Cardiovascular disease and risk of lung cancer incidence and mortality: A nationwide matched cohort study |
| title_full | Cardiovascular disease and risk of lung cancer incidence and mortality: A nationwide matched cohort study |
| title_fullStr | Cardiovascular disease and risk of lung cancer incidence and mortality: A nationwide matched cohort study |
| title_full_unstemmed | Cardiovascular disease and risk of lung cancer incidence and mortality: A nationwide matched cohort study |
| title_short | Cardiovascular disease and risk of lung cancer incidence and mortality: A nationwide matched cohort study |
| title_sort | cardiovascular disease and risk of lung cancer incidence and mortality a nationwide matched cohort study |
| topic | cardiovascular disease lung cancer incidence mortality survival |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.950971/full |
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