Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis
Osteoarthritis (OA) is the most common joint disease, usually occurring in middle-aged and elderly people. However, current treatment for OA in its early stages is ineffective, and drug therapy is often ineffective in slowing the progression of the disease. In fact, a deeper understanding of the und...
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| Format: | Article |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.946219/full |
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| author | Ganggang Zhai Likang Xiao Chenyang Jiang Songkai Yue Meng Zhang Jia zheng Zeming Liu Yonghui Dong Yonghui Dong |
| author_facet | Ganggang Zhai Likang Xiao Chenyang Jiang Songkai Yue Meng Zhang Jia zheng Zeming Liu Yonghui Dong Yonghui Dong |
| author_sort | Ganggang Zhai |
| collection | DOAJ |
| description | Osteoarthritis (OA) is the most common joint disease, usually occurring in middle-aged and elderly people. However, current treatment for OA in its early stages is ineffective, and drug therapy is often ineffective in slowing the progression of the disease. In fact, a deeper understanding of the underlying molecular mechanisms of OA could help us to better develop effective therapeutic measures. N6-methyladenosine (m6A) is a methylation that occurs at the adenosine N6-position, which is the most common internal modification on eukaryotic mRNAs. The role and mechanisms of m6A in mammalian gene regulation have been extensively studied. The “Writer”, “eraser”, and “reader” proteins are key proteins involved in the dynamic regulation of m6A modifications. Recent studies on post-transcriptional regulation alone have shown that m6a modification has an important role in the development of OA. This paper summarizes the specific regulatory processes of M6A in disease and reviews the role of m6A in OA, describing its pathophysiological role and molecular mechanisms, as well as its future research trends and potential clinical applications in OA. |
| first_indexed | 2024-12-12T13:26:49Z |
| format | Article |
| id | doaj.art-ff1653ee08e54c31a17bb87e37010f6b |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T13:26:49Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-ff1653ee08e54c31a17bb87e37010f6b2022-12-22T00:23:10ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-06-011010.3389/fcell.2022.946219946219Regulatory Role of N6-Methyladenosine (m6A) Modification in OsteoarthritisGanggang Zhai0Likang Xiao1Chenyang Jiang2Songkai Yue3Meng Zhang4Jia zheng5Zeming Liu6Yonghui Dong7Yonghui Dong8Department of Orthopedics, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Henan University People’s Hospital, Zhengzhou, ChinaDepartment of Orthopedics, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Henan University People’s Hospital, Zhengzhou, ChinaDepartment of Orthopedics, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Henan University People’s Hospital, Zhengzhou, ChinaDepartment of Orthopedics, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Henan University People’s Hospital, Zhengzhou, ChinaDepartment of Orthopedics, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Henan University People’s Hospital, Zhengzhou, ChinaDepartment of Orthopedics, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Henan University People’s Hospital, Zhengzhou, ChinaDepartment of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopedics, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Henan University People’s Hospital, Zhengzhou, ChinaMicrobiome Laboratory, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, ChinaOsteoarthritis (OA) is the most common joint disease, usually occurring in middle-aged and elderly people. However, current treatment for OA in its early stages is ineffective, and drug therapy is often ineffective in slowing the progression of the disease. In fact, a deeper understanding of the underlying molecular mechanisms of OA could help us to better develop effective therapeutic measures. N6-methyladenosine (m6A) is a methylation that occurs at the adenosine N6-position, which is the most common internal modification on eukaryotic mRNAs. The role and mechanisms of m6A in mammalian gene regulation have been extensively studied. The “Writer”, “eraser”, and “reader” proteins are key proteins involved in the dynamic regulation of m6A modifications. Recent studies on post-transcriptional regulation alone have shown that m6a modification has an important role in the development of OA. This paper summarizes the specific regulatory processes of M6A in disease and reviews the role of m6A in OA, describing its pathophysiological role and molecular mechanisms, as well as its future research trends and potential clinical applications in OA.https://www.frontiersin.org/articles/10.3389/fcell.2022.946219/fullN6-methyladenosinemolecular mechanismsosteoarthritisbiomarkertherapeutic target |
| spellingShingle | Ganggang Zhai Likang Xiao Chenyang Jiang Songkai Yue Meng Zhang Jia zheng Zeming Liu Yonghui Dong Yonghui Dong Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis Frontiers in Cell and Developmental Biology N6-methyladenosine molecular mechanisms osteoarthritis biomarker therapeutic target |
| title | Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis |
| title_full | Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis |
| title_fullStr | Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis |
| title_full_unstemmed | Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis |
| title_short | Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis |
| title_sort | regulatory role of n6 methyladenosine m6a modification in osteoarthritis |
| topic | N6-methyladenosine molecular mechanisms osteoarthritis biomarker therapeutic target |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.946219/full |
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