Paget's disease of bone in Tunisia: A study of 69 patients
Context: Paget's disease of bone is a common bone disease with a striking variation in its incidence and characteristics in different parts of the world. It is uncommonly reported in African patients. Aims: Given the lack of studies describing the characteristics of patients with Paget's d...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2020;volume=24;issue=5;spage=422;epage=427;aulast=Maatallah |
| _version_ | 1818957072052518912 |
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| author | Kaouther Maatallah Safa Rahmouni Saoussen Miladi Leila Rouached Hanen Ferjeni Alia Fazaa Ahmed Laatar Dhia Kaffel Wafa Hamdi |
| author_facet | Kaouther Maatallah Safa Rahmouni Saoussen Miladi Leila Rouached Hanen Ferjeni Alia Fazaa Ahmed Laatar Dhia Kaffel Wafa Hamdi |
| author_sort | Kaouther Maatallah |
| collection | DOAJ |
| description | Context: Paget's disease of bone is a common bone disease with a striking variation in its incidence and characteristics in different parts of the world. It is uncommonly reported in African patients. Aims: Given the lack of studies describing the characteristics of patients with Paget's disease of bone in North Africa, we aimed to describe demographic, clinical, biochemical, and imaging characteristics, as well as treatment outcomes of Tunisian patients with Paget's disease of bone. Subjects and Methods: This bicentric and retrospective study included patients with Paget's disease of bone. Clinical, laboratory, radiological profile, and response to treatment were analyzed. Results: Sixty-nine patients were identified. The mean age was 64.9 ± 11.6 years and 52.2% were women. One patient reported a positive family history. Seven patients were asymptomatic. Bone pain was the most common presenting symptom. Eight patients had a history of malignancy. In three patients, Paget's disease of bone was diagnosed as part of a metastatic workup. Monostotic disease was found in half of the cases. The most commonly involved sites were pelvis (43.5%), femur (21.7%), and spine (21.7%). The mean serum alkaline phosphatase level at presentation was 591 U/L (68–8380). Two patients received salmon calcitonin (2.8%) and 47 patients (68.1%) received bisphosphonates. After a mean follow-up of 55 months (2–240 months), bone pain improved in 43.1% of patients and the serum alkaline phosphate levels had normalized in 22 of them (43.1%). During follow-up, there was no malignant transformation. Conclusions: In this series of Tunisian patients, Paget's disease of bone had a female predominance and was usually monostotic. The clinical and radiological presentations were similar to the European series. |
| first_indexed | 2024-12-20T11:04:02Z |
| format | Article |
| id | doaj.art-ff17f288a7554521ba1179b99a7c62bd |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-12-20T11:04:02Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-ff17f288a7554521ba1179b99a7c62bd2022-12-21T19:42:55ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102020-01-0124542242710.4103/ijem.IJEM_239_20Paget's disease of bone in Tunisia: A study of 69 patientsKaouther MaatallahSafa RahmouniSaoussen MiladiLeila RouachedHanen FerjeniAlia FazaaAhmed LaatarDhia KaffelWafa HamdiContext: Paget's disease of bone is a common bone disease with a striking variation in its incidence and characteristics in different parts of the world. It is uncommonly reported in African patients. Aims: Given the lack of studies describing the characteristics of patients with Paget's disease of bone in North Africa, we aimed to describe demographic, clinical, biochemical, and imaging characteristics, as well as treatment outcomes of Tunisian patients with Paget's disease of bone. Subjects and Methods: This bicentric and retrospective study included patients with Paget's disease of bone. Clinical, laboratory, radiological profile, and response to treatment were analyzed. Results: Sixty-nine patients were identified. The mean age was 64.9 ± 11.6 years and 52.2% were women. One patient reported a positive family history. Seven patients were asymptomatic. Bone pain was the most common presenting symptom. Eight patients had a history of malignancy. In three patients, Paget's disease of bone was diagnosed as part of a metastatic workup. Monostotic disease was found in half of the cases. The most commonly involved sites were pelvis (43.5%), femur (21.7%), and spine (21.7%). The mean serum alkaline phosphatase level at presentation was 591 U/L (68–8380). Two patients received salmon calcitonin (2.8%) and 47 patients (68.1%) received bisphosphonates. After a mean follow-up of 55 months (2–240 months), bone pain improved in 43.1% of patients and the serum alkaline phosphate levels had normalized in 22 of them (43.1%). During follow-up, there was no malignant transformation. Conclusions: In this series of Tunisian patients, Paget's disease of bone had a female predominance and was usually monostotic. The clinical and radiological presentations were similar to the European series.http://www.ijem.in/article.asp?issn=2230-8210;year=2020;volume=24;issue=5;spage=422;epage=427;aulast=Maatallahbenign bone diseasebisphosphonateimagingpaget's disease of bonetreatment |
| spellingShingle | Kaouther Maatallah Safa Rahmouni Saoussen Miladi Leila Rouached Hanen Ferjeni Alia Fazaa Ahmed Laatar Dhia Kaffel Wafa Hamdi Paget's disease of bone in Tunisia: A study of 69 patients Indian Journal of Endocrinology and Metabolism benign bone disease bisphosphonate imaging paget's disease of bone treatment |
| title | Paget's disease of bone in Tunisia: A study of 69 patients |
| title_full | Paget's disease of bone in Tunisia: A study of 69 patients |
| title_fullStr | Paget's disease of bone in Tunisia: A study of 69 patients |
| title_full_unstemmed | Paget's disease of bone in Tunisia: A study of 69 patients |
| title_short | Paget's disease of bone in Tunisia: A study of 69 patients |
| title_sort | paget s disease of bone in tunisia a study of 69 patients |
| topic | benign bone disease bisphosphonate imaging paget's disease of bone treatment |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2020;volume=24;issue=5;spage=422;epage=427;aulast=Maatallah |
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