Linking biomarkers of oxidative stress and disease with flavonoid consumption: From experimental models to humans
Identification of the links among flavonoid consumption, mitigation of oxidative stress and improvement of disease in humans has significantly advanced in the last decades. This review used (−)-epicatechin (EC) as an example of dietary flavonoids, and inflammation, endothelial dysfunction/hypertensi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231721000628 |
| _version_ | 1818451410329534464 |
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| author | Patricia I. Oteiza Cesar G. Fraga Monica Galleano |
| author_facet | Patricia I. Oteiza Cesar G. Fraga Monica Galleano |
| author_sort | Patricia I. Oteiza |
| collection | DOAJ |
| description | Identification of the links among flavonoid consumption, mitigation of oxidative stress and improvement of disease in humans has significantly advanced in the last decades. This review used (−)-epicatechin (EC) as an example of dietary flavonoids, and inflammation, endothelial dysfunction/hypertension and insulin resistance/diabetes as paradigms of human disease. In these pathologies, oxidative stress is part of their development and/or their perpetuation. Evidence from both, rodent studies and characterization of mechanisms in cell cultures are encouraging and mostly support indirect antioxidant actions of EC and EC metabolites in endothelial dysfunction and insulin resistance. Human studies also show beneficial effects of EC on these pathologies based on biomarkers of disease. However, there is limited available information on oxidative stress biomarkers and flavonoid consumption to allow establishing conclusive associations. The evolving discovery of metabolites that could serve as reliable markers of intake of specific flavonoids constitutes a powerful tool to link flavonoid consumption to disease and prevention of oxidative stress in human populations. |
| first_indexed | 2024-12-14T21:06:45Z |
| format | Article |
| id | doaj.art-ff182f1daf7946b39e1931a2ddb08ad9 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-12-14T21:06:45Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-ff182f1daf7946b39e1931a2ddb08ad92022-12-21T22:47:23ZengElsevierRedox Biology2213-23172021-06-0142101914Linking biomarkers of oxidative stress and disease with flavonoid consumption: From experimental models to humansPatricia I. Oteiza0Cesar G. Fraga1Monica Galleano2Department of Nutrition, University of California, Davis, USA; Department of Environmental Toxicology, University of California, Davis, USA; Corresponding author. Department of Nutrition, University of California, Davis, USA.Department of Nutrition, University of California, Davis, USA; Fisicoquímica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina; Instituto de Bioquímica y Medicina Molecular (IBIMOL), Universidad de Buenos Aires-CONICET, Buenos Aires, ArgentinaFisicoquímica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina; Instituto de Bioquímica y Medicina Molecular (IBIMOL), Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina; Corresponding author. Fisicoquímica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.Identification of the links among flavonoid consumption, mitigation of oxidative stress and improvement of disease in humans has significantly advanced in the last decades. This review used (−)-epicatechin (EC) as an example of dietary flavonoids, and inflammation, endothelial dysfunction/hypertension and insulin resistance/diabetes as paradigms of human disease. In these pathologies, oxidative stress is part of their development and/or their perpetuation. Evidence from both, rodent studies and characterization of mechanisms in cell cultures are encouraging and mostly support indirect antioxidant actions of EC and EC metabolites in endothelial dysfunction and insulin resistance. Human studies also show beneficial effects of EC on these pathologies based on biomarkers of disease. However, there is limited available information on oxidative stress biomarkers and flavonoid consumption to allow establishing conclusive associations. The evolving discovery of metabolites that could serve as reliable markers of intake of specific flavonoids constitutes a powerful tool to link flavonoid consumption to disease and prevention of oxidative stress in human populations.http://www.sciencedirect.com/science/article/pii/S2213231721000628PolyphenolsAntioxidantsEpicatechinHypertensionDiabetesInflammation |
| spellingShingle | Patricia I. Oteiza Cesar G. Fraga Monica Galleano Linking biomarkers of oxidative stress and disease with flavonoid consumption: From experimental models to humans Redox Biology Polyphenols Antioxidants Epicatechin Hypertension Diabetes Inflammation |
| title | Linking biomarkers of oxidative stress and disease with flavonoid consumption: From experimental models to humans |
| title_full | Linking biomarkers of oxidative stress and disease with flavonoid consumption: From experimental models to humans |
| title_fullStr | Linking biomarkers of oxidative stress and disease with flavonoid consumption: From experimental models to humans |
| title_full_unstemmed | Linking biomarkers of oxidative stress and disease with flavonoid consumption: From experimental models to humans |
| title_short | Linking biomarkers of oxidative stress and disease with flavonoid consumption: From experimental models to humans |
| title_sort | linking biomarkers of oxidative stress and disease with flavonoid consumption from experimental models to humans |
| topic | Polyphenols Antioxidants Epicatechin Hypertension Diabetes Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2213231721000628 |
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