Impact of a Novel Hydrogel with Injectable Platelet-Rich Fibrin in Diabetic Wound Healing
Diabetic wounds are serious complications caused by diabetes mellitus (DM), which are further exacerbated by angiogenesis disorders and prolonged inflammation. Injectable platelet-rich fibrin (i-PRF) is rich in growth factors (GFs) and has been used for the repair and regeneration of diabetic wounds...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2023/7532637 |
| _version_ | 1797754277324652544 |
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| author | Limin Bai Xiaowei Zhang Xiaomei Li Susu Wang Yeshun Zhang Gang Xu |
| author_facet | Limin Bai Xiaowei Zhang Xiaomei Li Susu Wang Yeshun Zhang Gang Xu |
| author_sort | Limin Bai |
| collection | DOAJ |
| description | Diabetic wounds are serious complications caused by diabetes mellitus (DM), which are further exacerbated by angiogenesis disorders and prolonged inflammation. Injectable platelet-rich fibrin (i-PRF) is rich in growth factors (GFs) and has been used for the repair and regeneration of diabetic wounds; however, direct application of i-PRF has certain disadvantages, including the instability of the bioactive molecules. Sericin hydrogel, fabricated by silkworm-derived sericin, is a biocompatible material that has anti-inflammatory and healing-promoting properties. Therefore, in this study, we developed a novel hydrogel (named sericin/i-PRF hydrogel) using a simple one-step activation method. The in vitro studies showed that the rapid injectability of the sericin/i-PRF hydrogel allows it to adapt to the irregular shape of the wounds. Additionally, sericin hydrogel could prolong the release of i-PRF-derived bioactive GFs in the sericin/i-PRF hydrogel. Furthermore, sericin/i-PRF hydrogel effectively repaired diabetic wounds, promoted angiogenesis, and reduced inflammation levels in the diabetic wounds of nude mice. These results demonstrate that the sericin/i-PRF hydrogel is a promising agent for diabetic wound healing. |
| first_indexed | 2024-03-12T17:31:09Z |
| format | Article |
| id | doaj.art-ff185c559def4b8f85221a69018fb4ef |
| institution | Directory Open Access Journal |
| issn | 2314-6753 |
| language | English |
| last_indexed | 2024-03-12T17:31:09Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj.art-ff185c559def4b8f85221a69018fb4ef2023-08-05T00:00:02ZengHindawi LimitedJournal of Diabetes Research2314-67532023-01-01202310.1155/2023/7532637Impact of a Novel Hydrogel with Injectable Platelet-Rich Fibrin in Diabetic Wound HealingLimin Bai0Xiaowei Zhang1Xiaomei Li2Susu Wang3Yeshun Zhang4Gang Xu5Department of Burn and Plastic SurgeryDepartment of Burn and Plastic SurgeryDepartment of Burn and Plastic SurgeryCollege of BiotechnologyCollege of BiotechnologyDepartment of Burn and Plastic SurgeryDiabetic wounds are serious complications caused by diabetes mellitus (DM), which are further exacerbated by angiogenesis disorders and prolonged inflammation. Injectable platelet-rich fibrin (i-PRF) is rich in growth factors (GFs) and has been used for the repair and regeneration of diabetic wounds; however, direct application of i-PRF has certain disadvantages, including the instability of the bioactive molecules. Sericin hydrogel, fabricated by silkworm-derived sericin, is a biocompatible material that has anti-inflammatory and healing-promoting properties. Therefore, in this study, we developed a novel hydrogel (named sericin/i-PRF hydrogel) using a simple one-step activation method. The in vitro studies showed that the rapid injectability of the sericin/i-PRF hydrogel allows it to adapt to the irregular shape of the wounds. Additionally, sericin hydrogel could prolong the release of i-PRF-derived bioactive GFs in the sericin/i-PRF hydrogel. Furthermore, sericin/i-PRF hydrogel effectively repaired diabetic wounds, promoted angiogenesis, and reduced inflammation levels in the diabetic wounds of nude mice. These results demonstrate that the sericin/i-PRF hydrogel is a promising agent for diabetic wound healing.http://dx.doi.org/10.1155/2023/7532637 |
| spellingShingle | Limin Bai Xiaowei Zhang Xiaomei Li Susu Wang Yeshun Zhang Gang Xu Impact of a Novel Hydrogel with Injectable Platelet-Rich Fibrin in Diabetic Wound Healing Journal of Diabetes Research |
| title | Impact of a Novel Hydrogel with Injectable Platelet-Rich Fibrin in Diabetic Wound Healing |
| title_full | Impact of a Novel Hydrogel with Injectable Platelet-Rich Fibrin in Diabetic Wound Healing |
| title_fullStr | Impact of a Novel Hydrogel with Injectable Platelet-Rich Fibrin in Diabetic Wound Healing |
| title_full_unstemmed | Impact of a Novel Hydrogel with Injectable Platelet-Rich Fibrin in Diabetic Wound Healing |
| title_short | Impact of a Novel Hydrogel with Injectable Platelet-Rich Fibrin in Diabetic Wound Healing |
| title_sort | impact of a novel hydrogel with injectable platelet rich fibrin in diabetic wound healing |
| url | http://dx.doi.org/10.1155/2023/7532637 |
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