Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome
Sjögren’s syndrome (SS) is an autoimmune disease especially targeting exocrine glands, such as the salivary and lacrimal glands. A radical therapy for SS based on its etiology has not been established because of the complex pathogenesis of the disease. Several studies have demonstrated a relationshi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/7/1474 |
| _version_ | 1797415070575099904 |
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| author | Kunihiro Otsuka Mami Sato Takaaki Tsunematsu Naozumi Ishimaru |
| author_facet | Kunihiro Otsuka Mami Sato Takaaki Tsunematsu Naozumi Ishimaru |
| author_sort | Kunihiro Otsuka |
| collection | DOAJ |
| description | Sjögren’s syndrome (SS) is an autoimmune disease especially targeting exocrine glands, such as the salivary and lacrimal glands. A radical therapy for SS based on its etiology has not been established because of the complex pathogenesis of the disease. Several studies have demonstrated a relationship between virus infection and SS pathogenesis. In particular, infection with the Epstein-Barr (EB) virus among others is a potent factor associated with the onset or development of SS. Specifically, virus infection in the target organs of SS triggers or promotes autoreactive responses involving the process of autoantigen formation, antigen-presenting function, or T-cell response. Our review of recent research highlights the crucial roles of virus infection in the pathogenesis of SS and discusses the critical association between virus infection and the etiology of autoimmunity in SS. |
| first_indexed | 2024-03-09T05:42:45Z |
| format | Article |
| id | doaj.art-ff185c5f1e0a4b16979e91bf89256cfa |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T05:42:45Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-ff185c5f1e0a4b16979e91bf89256cfa2023-12-03T12:24:07ZengMDPI AGViruses1999-49152022-07-01147147410.3390/v14071474Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s SyndromeKunihiro Otsuka0Mami Sato1Takaaki Tsunematsu2Naozumi Ishimaru3Department of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8504, JapanDepartment of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8504, JapanDepartment of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8504, JapanDepartment of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8504, JapanSjögren’s syndrome (SS) is an autoimmune disease especially targeting exocrine glands, such as the salivary and lacrimal glands. A radical therapy for SS based on its etiology has not been established because of the complex pathogenesis of the disease. Several studies have demonstrated a relationship between virus infection and SS pathogenesis. In particular, infection with the Epstein-Barr (EB) virus among others is a potent factor associated with the onset or development of SS. Specifically, virus infection in the target organs of SS triggers or promotes autoreactive responses involving the process of autoantigen formation, antigen-presenting function, or T-cell response. Our review of recent research highlights the crucial roles of virus infection in the pathogenesis of SS and discusses the critical association between virus infection and the etiology of autoimmunity in SS.https://www.mdpi.com/1999-4915/14/7/1474virusEB virusautoimmunitySjögren’s syndrome |
| spellingShingle | Kunihiro Otsuka Mami Sato Takaaki Tsunematsu Naozumi Ishimaru Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome Viruses virus EB virus autoimmunity Sjögren’s syndrome |
| title | Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome |
| title_full | Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome |
| title_fullStr | Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome |
| title_full_unstemmed | Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome |
| title_short | Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome |
| title_sort | virus infections play crucial roles in the pathogenesis of sjogren s syndrome |
| topic | virus EB virus autoimmunity Sjögren’s syndrome |
| url | https://www.mdpi.com/1999-4915/14/7/1474 |
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