The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders
The human brain contains an estimated 100 billion neurons that must be systematically organized into functional neural circuits for it to function properly. These circuits range from short-range local signaling networks between neighboring neurons to long-range networks formed between various brain...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Neural Regeneration Research |
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| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=6;spage=1165;epage=1171;aulast=Razar |
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| author | Rafhanah Banu Bte Abdul Razar Yinghua Qu Saravanan Gunaseelan John Jia En Chua |
| author_facet | Rafhanah Banu Bte Abdul Razar Yinghua Qu Saravanan Gunaseelan John Jia En Chua |
| author_sort | Rafhanah Banu Bte Abdul Razar |
| collection | DOAJ |
| description | The human brain contains an estimated 100 billion neurons that must be systematically organized into functional neural circuits for it to function properly. These circuits range from short-range local signaling networks between neighboring neurons to long-range networks formed between various brain regions. Compelling converging evidence indicates that alterations in neural circuits arising from abnormalities during early neuronal development or neurodegeneration contribute significantly to the etiology of neurological disorders. Supporting this notion, efforts to identify genetic causes of these disorders have uncovered an over-representation of genes encoding proteins involved in the processes of neuronal differentiation, maturation, synaptogenesis and synaptic function. Fasciculation and elongation protein zeta-1, a Kinesin-1 adapter, has emerged as a key central player involved in many of these processes. Fasciculation and elongation protein zeta-1-dependent transport of synaptic cargoes and mitochondria is essential for neuronal development and synapse establishment. Furthermore, it acts downstream of guidance cue pathways to regulate axo-dendritic development. Significantly, perturbing its function causes abnormalities in neuronal development and synapse formation both in the brain as well as the peripheral nervous system. Mutations and deletions of the fasciculation and elongation protein zeta-1 gene are linked to neurodevelopmental disorders. Moreover, altered phosphorylation of the protein contributes to neurodegenerative disorders. Together, these findings strongly implicate the importance of fasciculation and elongation protein zeta-1 in the establishment of neuronal circuits and its maintenance. |
| first_indexed | 2024-12-20T23:09:37Z |
| format | Article |
| id | doaj.art-ff187ed575b24280a73ef6f6a62b3a80 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-20T23:09:37Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-ff187ed575b24280a73ef6f6a62b3a802022-12-21T19:23:46ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742022-01-011761165117110.4103/1673-5374.327327The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disordersRafhanah Banu Bte Abdul RazarYinghua QuSaravanan GunaseelanJohn Jia En ChuaThe human brain contains an estimated 100 billion neurons that must be systematically organized into functional neural circuits for it to function properly. These circuits range from short-range local signaling networks between neighboring neurons to long-range networks formed between various brain regions. Compelling converging evidence indicates that alterations in neural circuits arising from abnormalities during early neuronal development or neurodegeneration contribute significantly to the etiology of neurological disorders. Supporting this notion, efforts to identify genetic causes of these disorders have uncovered an over-representation of genes encoding proteins involved in the processes of neuronal differentiation, maturation, synaptogenesis and synaptic function. Fasciculation and elongation protein zeta-1, a Kinesin-1 adapter, has emerged as a key central player involved in many of these processes. Fasciculation and elongation protein zeta-1-dependent transport of synaptic cargoes and mitochondria is essential for neuronal development and synapse establishment. Furthermore, it acts downstream of guidance cue pathways to regulate axo-dendritic development. Significantly, perturbing its function causes abnormalities in neuronal development and synapse formation both in the brain as well as the peripheral nervous system. Mutations and deletions of the fasciculation and elongation protein zeta-1 gene are linked to neurodevelopmental disorders. Moreover, altered phosphorylation of the protein contributes to neurodegenerative disorders. Together, these findings strongly implicate the importance of fasciculation and elongation protein zeta-1 in the establishment of neuronal circuits and its maintenance.http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=6;spage=1165;epage=1171;aulast=Razarfasciculation and elongation protein zeta-1; neurological disorder; neuronal development; neuronal differentiation; neuronal networks; synapse formation; synaptic function |
| spellingShingle | Rafhanah Banu Bte Abdul Razar Yinghua Qu Saravanan Gunaseelan John Jia En Chua The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders Neural Regeneration Research fasciculation and elongation protein zeta-1; neurological disorder; neuronal development; neuronal differentiation; neuronal networks; synapse formation; synaptic function |
| title | The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders |
| title_full | The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders |
| title_fullStr | The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders |
| title_full_unstemmed | The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders |
| title_short | The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders |
| title_sort | importance of fasciculation and elongation protein zeta 1 in neural circuit establishment and neurological disorders |
| topic | fasciculation and elongation protein zeta-1; neurological disorder; neuronal development; neuronal differentiation; neuronal networks; synapse formation; synaptic function |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=6;spage=1165;epage=1171;aulast=Razar |
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