Deficits in Early Sensory and Cognitive Processing Are Related to Phase and Nonphase EEG Activity in Multiple Sclerosis Patients
Currently, there is scarce knowledge about the relation between spectral bands modulations and the basis of cognitive impairment in multiple sclerosis (MS). In this sense, analyzing the evoked or phase activity can confirm results from traditional event-related potential (ERP) studies. However, stud...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/11/5/629 |
| _version_ | 1797534209405878272 |
|---|---|
| author | Esteban Sarrias-Arrabal Sara Eichau Alejandro Galvao-Carmona Elvira Domínguez Guillermo Izquierdo Manuel Vázquez-Marrufo |
| author_facet | Esteban Sarrias-Arrabal Sara Eichau Alejandro Galvao-Carmona Elvira Domínguez Guillermo Izquierdo Manuel Vázquez-Marrufo |
| author_sort | Esteban Sarrias-Arrabal |
| collection | DOAJ |
| description | Currently, there is scarce knowledge about the relation between spectral bands modulations and the basis of cognitive impairment in multiple sclerosis (MS). In this sense, analyzing the evoked or phase activity can confirm results from traditional event-related potential (ERP) studies. However, studying the induced or nonphase activity may be necessary to elucidate hidden compensatory or affected cognitive mechanisms. In this study, 30 remitting-relapsing multiple sclerosis patients and 30 healthy controls (HCs) matched in sociodemographic variables performed a visual oddball task. The main goal was to analyze phase and nonphase alpha and gamma bands by applying temporal spectral evolution (TSE) and its potential relation with cognitive impairment in these patients. The behavioural results showed slower reaction time and poorer accuracy in MS patients compared to controls. In contrast, the time-frequency analysis of electroencephalography (EEG) revealed a delay in latency and lower amplitude in MS patients in evoked and induced alpha compared to controls. With respect to the gamma band, there were no differences between the groups. In summary, MS patients showed deficits in early sensorial (evoked alpha activity) and cognitive processing (induced alpha activity in longer latencies), whereas the induced gamma band supported the hypothesis of its role in translation of attentional focus (induced activity) and did not show strong activity in this paradigm (visual oddball). |
| first_indexed | 2024-03-10T11:27:23Z |
| format | Article |
| id | doaj.art-ff197ad972bd4eca9edd59682227b019 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T11:27:23Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-ff197ad972bd4eca9edd59682227b0192023-11-21T19:36:53ZengMDPI AGBrain Sciences2076-34252021-05-0111562910.3390/brainsci11050629Deficits in Early Sensory and Cognitive Processing Are Related to Phase and Nonphase EEG Activity in Multiple Sclerosis PatientsEsteban Sarrias-Arrabal0Sara Eichau1Alejandro Galvao-Carmona2Elvira Domínguez3Guillermo Izquierdo4Manuel Vázquez-Marrufo5Experimental Psychology Department, Faculty of Psychology, University of Seville, 41018 Seville, SpainUnit CSUR Multiple Sclerosis, Hospital Virgen Macarena, 41009 Seville, SpainDepartamento de Psicología, Universidad Loyola Andalucía, 41704 Sevilla, SpainUnit of Multiple Sclerosis, FISEVI, Hospital Virgen Macarena, 41009 Seville, SpainUnit of Multiple Sclerosis, Hospital VITHAS, 41950 Seville, SpainExperimental Psychology Department, Faculty of Psychology, University of Seville, 41018 Seville, SpainCurrently, there is scarce knowledge about the relation between spectral bands modulations and the basis of cognitive impairment in multiple sclerosis (MS). In this sense, analyzing the evoked or phase activity can confirm results from traditional event-related potential (ERP) studies. However, studying the induced or nonphase activity may be necessary to elucidate hidden compensatory or affected cognitive mechanisms. In this study, 30 remitting-relapsing multiple sclerosis patients and 30 healthy controls (HCs) matched in sociodemographic variables performed a visual oddball task. The main goal was to analyze phase and nonphase alpha and gamma bands by applying temporal spectral evolution (TSE) and its potential relation with cognitive impairment in these patients. The behavioural results showed slower reaction time and poorer accuracy in MS patients compared to controls. In contrast, the time-frequency analysis of electroencephalography (EEG) revealed a delay in latency and lower amplitude in MS patients in evoked and induced alpha compared to controls. With respect to the gamma band, there were no differences between the groups. In summary, MS patients showed deficits in early sensorial (evoked alpha activity) and cognitive processing (induced alpha activity in longer latencies), whereas the induced gamma band supported the hypothesis of its role in translation of attentional focus (induced activity) and did not show strong activity in this paradigm (visual oddball).https://www.mdpi.com/2076-3425/11/5/629alphaoddballEEGgammamultiple sclerosisevoked |
| spellingShingle | Esteban Sarrias-Arrabal Sara Eichau Alejandro Galvao-Carmona Elvira Domínguez Guillermo Izquierdo Manuel Vázquez-Marrufo Deficits in Early Sensory and Cognitive Processing Are Related to Phase and Nonphase EEG Activity in Multiple Sclerosis Patients Brain Sciences alpha oddball EEG gamma multiple sclerosis evoked |
| title | Deficits in Early Sensory and Cognitive Processing Are Related to Phase and Nonphase EEG Activity in Multiple Sclerosis Patients |
| title_full | Deficits in Early Sensory and Cognitive Processing Are Related to Phase and Nonphase EEG Activity in Multiple Sclerosis Patients |
| title_fullStr | Deficits in Early Sensory and Cognitive Processing Are Related to Phase and Nonphase EEG Activity in Multiple Sclerosis Patients |
| title_full_unstemmed | Deficits in Early Sensory and Cognitive Processing Are Related to Phase and Nonphase EEG Activity in Multiple Sclerosis Patients |
| title_short | Deficits in Early Sensory and Cognitive Processing Are Related to Phase and Nonphase EEG Activity in Multiple Sclerosis Patients |
| title_sort | deficits in early sensory and cognitive processing are related to phase and nonphase eeg activity in multiple sclerosis patients |
| topic | alpha oddball EEG gamma multiple sclerosis evoked |
| url | https://www.mdpi.com/2076-3425/11/5/629 |
| work_keys_str_mv | AT estebansarriasarrabal deficitsinearlysensoryandcognitiveprocessingarerelatedtophaseandnonphaseeegactivityinmultiplesclerosispatients AT saraeichau deficitsinearlysensoryandcognitiveprocessingarerelatedtophaseandnonphaseeegactivityinmultiplesclerosispatients AT alejandrogalvaocarmona deficitsinearlysensoryandcognitiveprocessingarerelatedtophaseandnonphaseeegactivityinmultiplesclerosispatients AT elviradominguez deficitsinearlysensoryandcognitiveprocessingarerelatedtophaseandnonphaseeegactivityinmultiplesclerosispatients AT guillermoizquierdo deficitsinearlysensoryandcognitiveprocessingarerelatedtophaseandnonphaseeegactivityinmultiplesclerosispatients AT manuelvazquezmarrufo deficitsinearlysensoryandcognitiveprocessingarerelatedtophaseandnonphaseeegactivityinmultiplesclerosispatients |