Neurite Orientation Dispersion and Density Imaging (NODDI) and duration of untreated psychosis in antipsychotic medication-naïve first episode psychosis patients
Background: Diffusion tensor imaging suggests that white matter alterations are already evident in first episode psychosis patients (FEP) and may become more prominent as the duration of untreated psychosis (DUP) increases. But because the tensor model lacks specificity, it remains unclear how to in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Neuroimage: Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666956021000039 |
| _version_ | 1829489855065751552 |
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| author | Nina Vanessa Kraguljac William Stonewall Monroe Thomas Anthony Ripu Daman Jindal Harrison Hill Adrienne Carol Lahti |
| author_facet | Nina Vanessa Kraguljac William Stonewall Monroe Thomas Anthony Ripu Daman Jindal Harrison Hill Adrienne Carol Lahti |
| author_sort | Nina Vanessa Kraguljac |
| collection | DOAJ |
| description | Background: Diffusion tensor imaging suggests that white matter alterations are already evident in first episode psychosis patients (FEP) and may become more prominent as the duration of untreated psychosis (DUP) increases. But because the tensor model lacks specificity, it remains unclear how to interpret findings on a biological level. Here, we used a biophysical diffusion model, Neurite Orientation Dispersion and Density Imaging (NODDI), to map microarchitecture in FEP, and to investigate associations between DUP and microarchitectural integrity. Methods: We scanned 78 antipsychotic medication-naïve FEP and 64 healthy controls using a multi-shell diffusion weighted sequence and used the NODDI toolbox to compute neurite density (ND), orientation dispersion index (ODI) and extracellular free water (FW) maps. AFNI’s 3dttest++ was used to compare diffusion maps between groups and to perform regression analyses with DUP. Results: We found that ND was decreased in commissural and association fibers but increased in projection fibers in FEP. ODI was largely increased regardless of fiber type, and FW showed a mix of increase in decrease across fiber tracts. We also demonstrated associations between DUP and microarchitecture for all NODDI indices. Conclusions: We demonstrated that complex microarchitecture abnormalities are already evident in antipsychotic-naïve FEP. ND alterations are differentially expressed depending on fiber type, while decreased fiber complexity appears to be a uniform marker of white matter deficit in the illness. Importantly, we identified an empirical link between longer DUP and greater white matter pathology across NODDI indices, underscoring the critical importance of early intervention in this devastating illness. |
| first_indexed | 2024-12-15T00:12:58Z |
| format | Article |
| id | doaj.art-ff199c1133cc40d8bb430e67ab643887 |
| institution | Directory Open Access Journal |
| issn | 2666-9560 |
| language | English |
| last_indexed | 2024-12-15T00:12:58Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neuroimage: Reports |
| spelling | doaj.art-ff199c1133cc40d8bb430e67ab6438872022-12-21T22:42:31ZengElsevierNeuroimage: Reports2666-95602021-03-0111100005Neurite Orientation Dispersion and Density Imaging (NODDI) and duration of untreated psychosis in antipsychotic medication-naïve first episode psychosis patientsNina Vanessa Kraguljac0William Stonewall Monroe1Thomas Anthony2Ripu Daman Jindal3Harrison Hill4Adrienne Carol Lahti5Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, USA; Corresponding author. Department of Psychiatry and Behavioral Neurobiology The University of Alabama at Birmingham SC 501, 1720 7th Ave S, Birmingham, AL, 35294-0017, USA.Department of Electrical and Computer Engineering/ IT Research Computing, University of Alabama at Birmingham, USADepartment of Electrical and Computer Engineering/ IT Research Computing, University of Alabama at Birmingham, USADepartment of Neurology, Birmingham VA Medical Center, USADepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, USADepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, USABackground: Diffusion tensor imaging suggests that white matter alterations are already evident in first episode psychosis patients (FEP) and may become more prominent as the duration of untreated psychosis (DUP) increases. But because the tensor model lacks specificity, it remains unclear how to interpret findings on a biological level. Here, we used a biophysical diffusion model, Neurite Orientation Dispersion and Density Imaging (NODDI), to map microarchitecture in FEP, and to investigate associations between DUP and microarchitectural integrity. Methods: We scanned 78 antipsychotic medication-naïve FEP and 64 healthy controls using a multi-shell diffusion weighted sequence and used the NODDI toolbox to compute neurite density (ND), orientation dispersion index (ODI) and extracellular free water (FW) maps. AFNI’s 3dttest++ was used to compare diffusion maps between groups and to perform regression analyses with DUP. Results: We found that ND was decreased in commissural and association fibers but increased in projection fibers in FEP. ODI was largely increased regardless of fiber type, and FW showed a mix of increase in decrease across fiber tracts. We also demonstrated associations between DUP and microarchitecture for all NODDI indices. Conclusions: We demonstrated that complex microarchitecture abnormalities are already evident in antipsychotic-naïve FEP. ND alterations are differentially expressed depending on fiber type, while decreased fiber complexity appears to be a uniform marker of white matter deficit in the illness. Importantly, we identified an empirical link between longer DUP and greater white matter pathology across NODDI indices, underscoring the critical importance of early intervention in this devastating illness.http://www.sciencedirect.com/science/article/pii/S2666956021000039First episode psychosisWhite matterDuration of untreated psychosisFree waterNeurite densityOrientation dispersion |
| spellingShingle | Nina Vanessa Kraguljac William Stonewall Monroe Thomas Anthony Ripu Daman Jindal Harrison Hill Adrienne Carol Lahti Neurite Orientation Dispersion and Density Imaging (NODDI) and duration of untreated psychosis in antipsychotic medication-naïve first episode psychosis patients Neuroimage: Reports First episode psychosis White matter Duration of untreated psychosis Free water Neurite density Orientation dispersion |
| title | Neurite Orientation Dispersion and Density Imaging (NODDI) and duration of untreated psychosis in antipsychotic medication-naïve first episode psychosis patients |
| title_full | Neurite Orientation Dispersion and Density Imaging (NODDI) and duration of untreated psychosis in antipsychotic medication-naïve first episode psychosis patients |
| title_fullStr | Neurite Orientation Dispersion and Density Imaging (NODDI) and duration of untreated psychosis in antipsychotic medication-naïve first episode psychosis patients |
| title_full_unstemmed | Neurite Orientation Dispersion and Density Imaging (NODDI) and duration of untreated psychosis in antipsychotic medication-naïve first episode psychosis patients |
| title_short | Neurite Orientation Dispersion and Density Imaging (NODDI) and duration of untreated psychosis in antipsychotic medication-naïve first episode psychosis patients |
| title_sort | neurite orientation dispersion and density imaging noddi and duration of untreated psychosis in antipsychotic medication naive first episode psychosis patients |
| topic | First episode psychosis White matter Duration of untreated psychosis Free water Neurite density Orientation dispersion |
| url | http://www.sciencedirect.com/science/article/pii/S2666956021000039 |
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