Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design of a prospective, multicentre, observational, comparative study
Introduction Data are lacking on the extent to which patients with non-valvular atrial fibrillation (AF) who are aged ≥80 years benefit from ablation treatment. The question pertains especially to patients’ postablation quality of life (QoL) and long-term clinical outcomes.Methods and analysis We ar...
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| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2023-02-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/2/e068894.full |
| _version_ | 1797902616832770048 |
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| author | Kengo Kusano Ayako Okada Koji Miyamoto Eizo Tachibana Wataru Shimizu Masato Murakami Tomoo Harada Kojiro Tanimoto Takeshi Kato Satoru Sakagami Katsuhito Fujiu Tatsuya Hayashi Yasuo Okumura Kazuhiro Satomi Tomoyuki Shiozawa Hideki Kobayashi Michifumi Tokuda Teiichi Yamane Ryohsuke Narui Seigo Yamashita Satoru Miyanaga Ikutaro Nakajima Hidehira Fukaya Hajime Kihara Shiro Nakahara Koichi Nagashima Kenta Murotani Shinya Suzuki Ryuta Watanabe Katsuaki Yokoyama Hidemori Hayashi Yu-ki Iwasaki Yuhi Fujimoto Yasushi Mukai Koichiro Ejima Takayuki Otsuka Masaomi Kimura Masahide Harada Junjiroh Koyama Hideharu Okamatsu Mitsuru Takami Morio Shoda Kenichi Hiroshima Tadashi Fujino Keijiro Nakamura Koji Kumagai Yuji Watari Mina Hatsuno Kazuki Iso Kazumasa Sonoda Yoshiyasu Aizawa Akio Chikata Masaru Inoue Hitoshi Minamiguchi Nobuhiko Makino Yoshinao Yazaki Hideshi Aoyagi Makoto Ichikawa Hironori Haruta Takafumi Hiro Kimie Okubo Ken Arima Taiki Tojo Yoshiaki Fukuda Koji Oiwa Tamami Fujiishi Masashi Akabane Norikazu Ishikawa Haruna Tabuchi Kenjiro Miyamoto Hiroshi Mase |
| author_facet | Kengo Kusano Ayako Okada Koji Miyamoto Eizo Tachibana Wataru Shimizu Masato Murakami Tomoo Harada Kojiro Tanimoto Takeshi Kato Satoru Sakagami Katsuhito Fujiu Tatsuya Hayashi Yasuo Okumura Kazuhiro Satomi Tomoyuki Shiozawa Hideki Kobayashi Michifumi Tokuda Teiichi Yamane Ryohsuke Narui Seigo Yamashita Satoru Miyanaga Ikutaro Nakajima Hidehira Fukaya Hajime Kihara Shiro Nakahara Koichi Nagashima Kenta Murotani Shinya Suzuki Ryuta Watanabe Katsuaki Yokoyama Hidemori Hayashi Yu-ki Iwasaki Yuhi Fujimoto Yasushi Mukai Koichiro Ejima Takayuki Otsuka Masaomi Kimura Masahide Harada Junjiroh Koyama Hideharu Okamatsu Mitsuru Takami Morio Shoda Kenichi Hiroshima Tadashi Fujino Keijiro Nakamura Koji Kumagai Yuji Watari Mina Hatsuno Kazuki Iso Kazumasa Sonoda Yoshiyasu Aizawa Akio Chikata Masaru Inoue Hitoshi Minamiguchi Nobuhiko Makino Yoshinao Yazaki Hideshi Aoyagi Makoto Ichikawa Hironori Haruta Takafumi Hiro Kimie Okubo Ken Arima Taiki Tojo Yoshiaki Fukuda Koji Oiwa Tamami Fujiishi Masashi Akabane Norikazu Ishikawa Haruna Tabuchi Kenjiro Miyamoto Hiroshi Mase |
| author_sort | Kengo Kusano |
| collection | DOAJ |
| description | Introduction Data are lacking on the extent to which patients with non-valvular atrial fibrillation (AF) who are aged ≥80 years benefit from ablation treatment. The question pertains especially to patients’ postablation quality of life (QoL) and long-term clinical outcomes.Methods and analysis We are initiating a prospective, registry-based, multicentre observational study that will include patients aged ≥80 years with non-valvular AF who choose to undergo treatment by catheter ablation and, for comparison, such patients who do not choose to undergo ablation (either according to their physician’s advice or their own preference). Study subjects are to be enrolled from 52 participant hospitals and three clinics located throughout Japan from 1 June 2022 to 31 December 2023, and each will be followed up for 1 year. The planned sample size is 660, comprising 220 ablation group patients and 440 non-ablation group patients. The primary endpoint will be the composite incidence of stroke/transient ischaemic attack (TIA) or systemic embolism (SE), another cardiovascular event, major bleeding and/or death from any cause. Other clinical events such as postablation AF recurrence, a fall or bone fracture will be recorded. We will collect standard clinical background information plus each patient’s Clinical Frailty Scale score, AF-related symptoms, QoL (Five-Level Version of EQ-5D) scores, Mini-Mental State Examination (optional) score and laboratory test results, including measures of nutritional status, on entry into the study and 1 year later, and serial changes in symptoms and QoL will also be secondary endpoints. Propensity score matching will be performed to account for covariates that could affect study results.Ethics and dissemination The study conforms to the Declaration of Helsinki and the Ethical Guidelines for Clinical Studies issued by the Ministry of Health, Labour and Welfare, Japan. Results of the study will be published in one or more peer-reviewed journals.Trial registration number UMIN000047023. |
| first_indexed | 2024-04-10T09:20:28Z |
| format | Article |
| id | doaj.art-ff19ebd687ab4567904e4380b81de8ee |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-10T09:20:28Z |
| publishDate | 2023-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-ff19ebd687ab4567904e4380b81de8ee2023-02-20T13:00:09ZengBMJ Publishing GroupBMJ Open2044-60552023-02-0113210.1136/bmjopen-2022-068894Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design of a prospective, multicentre, observational, comparative studyKengo Kusano0Ayako Okada1Koji Miyamoto2Eizo Tachibana3Wataru Shimizu4Masato Murakami5Tomoo Harada6Kojiro Tanimoto7Takeshi Kato8Satoru Sakagami9Katsuhito Fujiu10Tatsuya Hayashi11Yasuo Okumura12Kazuhiro Satomi13Tomoyuki Shiozawa14Hideki Kobayashi15Michifumi Tokuda16Teiichi Yamane17Ryohsuke Narui18Seigo Yamashita19Satoru Miyanaga20Ikutaro Nakajima21Hidehira Fukaya22Hajime Kihara23Shiro Nakahara24Koichi Nagashima25Kenta Murotani26Shinya Suzuki27Ryuta Watanabe28Katsuaki Yokoyama29Hidemori Hayashi30Yu-ki Iwasaki31Yuhi Fujimoto32Yasushi Mukai33Koichiro Ejima34Takayuki Otsuka35Masaomi Kimura36Masahide Harada37Junjiroh Koyama38Hideharu Okamatsu39Mitsuru Takami40Morio Shoda41Kenichi Hiroshima42Tadashi Fujino43Keijiro Nakamura44Koji Kumagai45Yuji Watari46Mina Hatsuno47Kazuki Iso48Kazumasa Sonoda49Yoshiyasu Aizawa50Akio Chikata51Masaru Inoue52Hitoshi Minamiguchi53Nobuhiko Makino54Yoshinao Yazaki55Hideshi Aoyagi56Makoto Ichikawa57Hironori Haruta58Takafumi Hiro59Kimie Okubo60Ken Arima61Taiki Tojo62Yoshiaki Fukuda63Koji Oiwa64Tamami Fujiishi65Masashi Akabane66Norikazu Ishikawa67Haruna Tabuchi68Kenjiro Miyamoto69Hiroshi Mase70Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Cardiovascular Medicine, Shinshu University Hospital, Matsumoto, Nagano, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDivision of Cardiology, Kawaguchi Municipal Medical Center, Kawaguchi, Saitama, JapanDepartment of Cardiovascular Medicine, Nippon Medical School Hospital, Bunkyo-ku, Tokyo, JapanDivision of Cardiology, Shonan Kamakura General Hospital, Kamakura, Kanagawa, JapanDepartment of Cardiology, St.Marianna University School of Medicine Hospital, Kawasaki, Kanagawa, JapanDeparatment of Cardiology, National Hospital Organisation Tokyo Medical Center, Meguro-ku, Tokyo, JapanDepartment of Cardiovascular and Internal Medicine, Kanazawa University Hospital, Kanazawa, Ishikawa, JapanDepartment of Cardiology, National Hospital Organization, Kanazawa Medical Center, Kanazawa, Ishikawa, JapanDepartment of Cardiovascular Medicine, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, JapanDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Omiya, Saitama, JapanDepartment of Cardiology, Nihon University Itabashi Hospital, Itabashi-ku, Tokyo, JapanDepartment of Cardiology, Tokyo Medical University, Shinjuku-ku, Tokyo, JapanDepartment of Cardiology, Juntendo University Shizuoka Hospital, Izunokuni, Shizuoka, JapanDepartment of Cardiovascular Medicine, Shinshu University Hospital, Matsumoto, Nagano, JapanDivision of Cardiology, Department of Internal Medicine, The Jikei University Katsushika Medical Center, Katsushika-ku, Tokyo, JapanDivision of Cardiology, Department of Internal Medicine, Jikei University School of Medicine, Minato-ku, Tokyo, JapanDivision of Cardiology, Department of Internal Medicine, The Jikei University Kashiwa Hospital, Kashiwa, Chiba, JapanDivision of Cardiology, Department of Internal Medicine, Jikei University School of Medicine, Minato-ku, Tokyo, JapanDivision of Cardiology, Department of Internal Medicine, The Jikei University Daisan Hospital, Komae, Tokyo, JapanDepartment of Cardiology, St.Marianna University School of Medicine Hospital, Kawasaki, Kanagawa, JapanDepartment of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, JapanDepartment of Internal Medicine, Kihara Cardiovascular Clinic, Asahikawa, Hokkaido, JapanDepartment of Cardiology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Saitama, JapanDepartment of Cardiology, Nihon University Itabashi Hospital, Itabashi-ku, Tokyo, JapanBiostatistics Center, Kurume University School of Medicine, Kurume, Fukuoka, JapanDepartment of Cardiovascular Medicine, The Cardiovascular Institute, Minato-ku, Tokyo, JapanDepartment of Cardiology, Nihon University Itabashi Hospital, Itabashi-ku, Tokyo, JapanDepartment of Cardiology, Nihon University Hospital, Chiyoda-ku, Tokyo, JapanDepartment of Cardiovascular Biology and Medicine, Juntendo University Graduate Schoool of Medicine, Bunkyo-ku, Tokyo, JapanDepartment of Cardiovascular Medicine, Nippon Medical School Hospital, Bunkyo-ku, Tokyo, JapanDepartment of Cardiovascular Medicine, Nippon Medical School Hospital, Bunkyo-ku, Tokyo, JapanDepartment of Cardiovascular Medicine, Japanese Red Cross Fukuoka Hospital, Fukuoka City, Fukuoka, JapanDepartment of Cardiology, Minamino Cardiovascular Hospital, Hachioji, Tokyo, JapanDepartment of Cardiovascular Medicine, The Cardiovascular Institute, Minato-ku, Tokyo, JapanDivison of Cardiology, Pulmonary Medicine and Nephrology, Hirosaki University School of Medicine, Hirosaki, Aomori, JapanDepartment of Cardiology, Fujita Health University, Toyoake, Aichi, JapanCardiovascular Center, Saiseikai Kumamoto Hospital, Kumamoto City, Kumamoto, JapanCardiovascular Center, Saiseikai Kumamoto Hospital, Kumamoto City, Kumamoto, JapanDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, JapanDepartment of Cardiology, Tokyo Women`s Medical University Hospital, Shinjuku-ku, Tokyo, JapanDepartment of Cardiology, Kokura Memorial Hospital, Kitakyushu, Fukuoka, JapanDepartment of Cardiovascular Medicine, Toho University Graduate School of Medicine, Ota-ku, Tokyo, JapanDivision of Cardiovascular Medicine, Toho University Ohashi Medical Center, Meguro-ku, Tokyo, JapanDepartment of Cardiovascular Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, JapanDepartment of Cardiology, Teikyo University Hospital, Itabashi-ku, Tokyo, JapanDepartment of Cardiology, Teikyo University Hospital, Itabashi-ku, Tokyo, JapanDivision of Cardiology, Kawaguchi Municipal Medical Center, Kawaguchi, Saitama, JapanDivision of Cardiology, Department of Medicine, Tokyo Rinkai Hospital, Edogawa-ku, Tokyo, JapanDepartment of Cardiology, International University of Health and Welfare Narita Hospital, Narita, Chiba, JapanDepartment of Cardiology, Toyama Prefectural Central Hospital, Toyama City, Toyama, JapanDepartment of Cardiology, National Hospital Organization, Kanazawa Medical Center, Kanazawa, Ishikawa, JapanDepartment of Cardiology, Osaka Police Hospital, Osaka City, Osaka, JapanDepartment of Cardiology, Osaka Police Hospital, Osaka City, Osaka, JapanDepartment of Cardiology, Tokyo Medical University, Shinjuku-ku, Tokyo, JapanDepartment of Cardiovascular Medicine, St Luke`s International University, Chuo-ku, Tokyo, JapanDepartment of Cardiology, Sekishin Clinic, Kawagoe, Saitama, JapanDepartment of Cardiology, TMG Asaka Medical Center, Asaka, Saitama, JapanCirculatory medicine, Akabane Central General Hospital, Kita-ku, Tokyo, JapanDepartment of Cardiology, Itabashi Medical Association Hospital, Itabashi-ku, Tokyo, JapanDepartment of Cardiology, Kasukabe Medical Center, Kasukabe, Saitama, JapanDepartment of Cardiovascular medicine, Kitasato University Kitasato Institute Hospital, Minato-ku, Tokyo, JapanDepartment of Cardiology, Higashi Saitama General Hospital, Satte, Saitama, JapanCardiology, Japan Community Health are Organization, Yokohama Chuo Hospital, Yokohama, Kanagawa, JapanDepartment of Cardiology, JCHO Sagamino Hospital, Sagamihara, Kanagawa, JapanDepartment of Cardiology, Akabane Clinic, Outawara, Tochigi, JapanDepartment of Cardiology, Zengyodanchi Ishikawa Clinic, Fujisawa, Kanagawa, JapanDepartment of Cardiology, Juntendo University Nerima Hospital, Nerima-ku, Tokyo, JapanDepartment of Cardiology, Sapporo Shiroishi Memorial Hospital, Hokkaido, Sapporo, JapanDepartment of Cardiology, Showa University Fujigaoka Hospital, Yokohama, Kanagawa, JapanIntroduction Data are lacking on the extent to which patients with non-valvular atrial fibrillation (AF) who are aged ≥80 years benefit from ablation treatment. The question pertains especially to patients’ postablation quality of life (QoL) and long-term clinical outcomes.Methods and analysis We are initiating a prospective, registry-based, multicentre observational study that will include patients aged ≥80 years with non-valvular AF who choose to undergo treatment by catheter ablation and, for comparison, such patients who do not choose to undergo ablation (either according to their physician’s advice or their own preference). Study subjects are to be enrolled from 52 participant hospitals and three clinics located throughout Japan from 1 June 2022 to 31 December 2023, and each will be followed up for 1 year. The planned sample size is 660, comprising 220 ablation group patients and 440 non-ablation group patients. The primary endpoint will be the composite incidence of stroke/transient ischaemic attack (TIA) or systemic embolism (SE), another cardiovascular event, major bleeding and/or death from any cause. Other clinical events such as postablation AF recurrence, a fall or bone fracture will be recorded. We will collect standard clinical background information plus each patient’s Clinical Frailty Scale score, AF-related symptoms, QoL (Five-Level Version of EQ-5D) scores, Mini-Mental State Examination (optional) score and laboratory test results, including measures of nutritional status, on entry into the study and 1 year later, and serial changes in symptoms and QoL will also be secondary endpoints. Propensity score matching will be performed to account for covariates that could affect study results.Ethics and dissemination The study conforms to the Declaration of Helsinki and the Ethical Guidelines for Clinical Studies issued by the Ministry of Health, Labour and Welfare, Japan. Results of the study will be published in one or more peer-reviewed journals.Trial registration number UMIN000047023.https://bmjopen.bmj.com/content/13/2/e068894.full |
| spellingShingle | Kengo Kusano Ayako Okada Koji Miyamoto Eizo Tachibana Wataru Shimizu Masato Murakami Tomoo Harada Kojiro Tanimoto Takeshi Kato Satoru Sakagami Katsuhito Fujiu Tatsuya Hayashi Yasuo Okumura Kazuhiro Satomi Tomoyuki Shiozawa Hideki Kobayashi Michifumi Tokuda Teiichi Yamane Ryohsuke Narui Seigo Yamashita Satoru Miyanaga Ikutaro Nakajima Hidehira Fukaya Hajime Kihara Shiro Nakahara Koichi Nagashima Kenta Murotani Shinya Suzuki Ryuta Watanabe Katsuaki Yokoyama Hidemori Hayashi Yu-ki Iwasaki Yuhi Fujimoto Yasushi Mukai Koichiro Ejima Takayuki Otsuka Masaomi Kimura Masahide Harada Junjiroh Koyama Hideharu Okamatsu Mitsuru Takami Morio Shoda Kenichi Hiroshima Tadashi Fujino Keijiro Nakamura Koji Kumagai Yuji Watari Mina Hatsuno Kazuki Iso Kazumasa Sonoda Yoshiyasu Aizawa Akio Chikata Masaru Inoue Hitoshi Minamiguchi Nobuhiko Makino Yoshinao Yazaki Hideshi Aoyagi Makoto Ichikawa Hironori Haruta Takafumi Hiro Kimie Okubo Ken Arima Taiki Tojo Yoshiaki Fukuda Koji Oiwa Tamami Fujiishi Masashi Akabane Norikazu Ishikawa Haruna Tabuchi Kenjiro Miyamoto Hiroshi Mase Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design of a prospective, multicentre, observational, comparative study BMJ Open |
| title | Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design of a prospective, multicentre, observational, comparative study |
| title_full | Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design of a prospective, multicentre, observational, comparative study |
| title_fullStr | Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design of a prospective, multicentre, observational, comparative study |
| title_full_unstemmed | Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design of a prospective, multicentre, observational, comparative study |
| title_short | Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design of a prospective, multicentre, observational, comparative study |
| title_sort | registry for evaluating healthy life expectancy and long term outcomes after catheter ablation of atrial fibrillation in the very elderly rehealth af study rationale and design of a prospective multicentre observational comparative study |
| url | https://bmjopen.bmj.com/content/13/2/e068894.full |
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registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT kazumasasonoda registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT yoshiyasuaizawa registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT akiochikata registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT masaruinoue registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT hitoshiminamiguchi registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT nobuhikomakino registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT yoshinaoyazaki registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT hideshiaoyagi registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT makotoichikawa registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT hironoriharuta registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT takafumihiro registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT kimieokubo registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT kenarima registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT taikitojo registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT yoshiakifukuda registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT kojioiwa registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT tamamifujiishi registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT masashiakabane registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT norikazuishikawa registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT harunatabuchi registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT kenjiromiyamoto registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy AT hiroshimase registryforevaluatinghealthylifeexpectancyandlongtermoutcomesaftercatheterablationofatrialfibrillationintheveryelderlyrehealthafstudyrationaleanddesignofaprospectivemulticentreobservationalcomparativestudy |