Magnetic resonance guided focused ultrasound for treatment of bone tumors
Aims: Magnetic resonance guided focused ultrasound (MRgFUS) is a new modality in the management of primary and secondary bone tumors. We aimed to investigate the safety, efficacy, and feasibility of using MRgFUS for the treatment of (1) benign bone tumors with the intent of complete tumor ablation,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-06-01
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| Series: | Journal of Orthopaedic Surgery |
| Online Access: | https://doi.org/10.1177/2309499017716256 |
| _version_ | 1818300633684377600 |
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| author | Vivek Ajit Singh Syed Usman Shah Nor Faissal Yasin Basri Johan Jeet Abdullah |
| author_facet | Vivek Ajit Singh Syed Usman Shah Nor Faissal Yasin Basri Johan Jeet Abdullah |
| author_sort | Vivek Ajit Singh |
| collection | DOAJ |
| description | Aims: Magnetic resonance guided focused ultrasound (MRgFUS) is a new modality in the management of primary and secondary bone tumors. We aimed to investigate the safety, efficacy, and feasibility of using MRgFUS for the treatment of (1) benign bone tumors with the intent of complete tumor ablation, (2) primary malignant bone tumors with the intent to assess its effectiveness in causing tumor necrosis, and (3) metastatic bone disease with the intent of pain relief. Method: Twenty-four patients with benign bone tumors, primary malignant bone tumors, and metastatic bone disease were treated with one session of MRgFUS. Contrast-enhanced (CE) magnetic resonance imaging (MRI) was carried out post-procedure to assess and quantify the area of ablation. Those with malignant primary tumors had the tumors resected 2 weeks after the treatment and the ablated areas were examined histopathologically (HPE). The other patients were followed up for 3 months to assess for the side effects and pain scores. Results: Significant volume of ablation was noted on CE MRI after the treatment. Benign bone tumors were ablated with minimal adverse effects. Metastatic bone disease was successfully treated with significant decrease in pain scores. Ablated primary malignant tumors showed significant coagulative necrosis on MRI and the HPE showed 100% necrosis. Pain scores significantly decreased 3 months after the procedure. Only two patients had superficial skin blistering and three patients had increase in pain scores immediately after treatment. Conclusion: MRgFUS is effective, safe, and noninvasive procedure that can be an adjunct in the management of primary and metastatic bone tumors. |
| first_indexed | 2024-12-13T05:10:13Z |
| format | Article |
| id | doaj.art-ff1a11cd6b94456697e3b02691e3637d |
| institution | Directory Open Access Journal |
| issn | 2309-4990 |
| language | English |
| last_indexed | 2024-12-13T05:10:13Z |
| publishDate | 2017-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Orthopaedic Surgery |
| spelling | doaj.art-ff1a11cd6b94456697e3b02691e3637d2022-12-21T23:58:33ZengSAGE PublishingJournal of Orthopaedic Surgery2309-49902017-06-012510.1177/2309499017716256Magnetic resonance guided focused ultrasound for treatment of bone tumorsVivek Ajit Singh0Syed Usman Shah1Nor Faissal Yasin2Basri Johan Jeet Abdullah3 Department of Orthopaedics (Noceral), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Department of Orthopaedics (Noceral), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Department of Orthopaedics (Noceral), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Department of Biomedical Imaging, University Malaya Medical Center, Kuala Lumpur, MalaysiaAims: Magnetic resonance guided focused ultrasound (MRgFUS) is a new modality in the management of primary and secondary bone tumors. We aimed to investigate the safety, efficacy, and feasibility of using MRgFUS for the treatment of (1) benign bone tumors with the intent of complete tumor ablation, (2) primary malignant bone tumors with the intent to assess its effectiveness in causing tumor necrosis, and (3) metastatic bone disease with the intent of pain relief. Method: Twenty-four patients with benign bone tumors, primary malignant bone tumors, and metastatic bone disease were treated with one session of MRgFUS. Contrast-enhanced (CE) magnetic resonance imaging (MRI) was carried out post-procedure to assess and quantify the area of ablation. Those with malignant primary tumors had the tumors resected 2 weeks after the treatment and the ablated areas were examined histopathologically (HPE). The other patients were followed up for 3 months to assess for the side effects and pain scores. Results: Significant volume of ablation was noted on CE MRI after the treatment. Benign bone tumors were ablated with minimal adverse effects. Metastatic bone disease was successfully treated with significant decrease in pain scores. Ablated primary malignant tumors showed significant coagulative necrosis on MRI and the HPE showed 100% necrosis. Pain scores significantly decreased 3 months after the procedure. Only two patients had superficial skin blistering and three patients had increase in pain scores immediately after treatment. Conclusion: MRgFUS is effective, safe, and noninvasive procedure that can be an adjunct in the management of primary and metastatic bone tumors.https://doi.org/10.1177/2309499017716256 |
| spellingShingle | Vivek Ajit Singh Syed Usman Shah Nor Faissal Yasin Basri Johan Jeet Abdullah Magnetic resonance guided focused ultrasound for treatment of bone tumors Journal of Orthopaedic Surgery |
| title | Magnetic resonance guided focused ultrasound for treatment of bone tumors |
| title_full | Magnetic resonance guided focused ultrasound for treatment of bone tumors |
| title_fullStr | Magnetic resonance guided focused ultrasound for treatment of bone tumors |
| title_full_unstemmed | Magnetic resonance guided focused ultrasound for treatment of bone tumors |
| title_short | Magnetic resonance guided focused ultrasound for treatment of bone tumors |
| title_sort | magnetic resonance guided focused ultrasound for treatment of bone tumors |
| url | https://doi.org/10.1177/2309499017716256 |
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