Metastatic mucinous tubular and spindle cell carcinoma of the kidney responding to nivolumab plus ipilimumab
Introduction Mucinous tubular and spindle cell carcinoma is a rare subtype of renal cell carcinoma. Little is known regarding the efficacy of systemic therapy on its metastatic form because of its rarity. Case presentation We present the case of a patient with metastatic mucinous tubular and spindle...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-09-01
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| Series: | IJU Case Reports |
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| Online Access: | https://doi.org/10.1002/iju5.12342 |
| _version_ | 1819093408541573120 |
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| author | Hirotaka Fuchizawa Toshiki Kijima Atsuko Takada‐Owada Yoji Nagashima Akihito Okazaki Megumi Yokoyama Daisaku Nishihara Kazuyuki Ishida Takao Kamai |
| author_facet | Hirotaka Fuchizawa Toshiki Kijima Atsuko Takada‐Owada Yoji Nagashima Akihito Okazaki Megumi Yokoyama Daisaku Nishihara Kazuyuki Ishida Takao Kamai |
| author_sort | Hirotaka Fuchizawa |
| collection | DOAJ |
| description | Introduction Mucinous tubular and spindle cell carcinoma is a rare subtype of renal cell carcinoma. Little is known regarding the efficacy of systemic therapy on its metastatic form because of its rarity. Case presentation We present the case of a patient with metastatic mucinous tubular and spindle cell carcinoma who achieved durable complete remission of multiple osseous metastases after undergoing cytoreductive nephrectomy followed by combination immunotherapy (ipilimumab plus nivolumab). Immunohistochemical analyses of the primary tumor revealed the presence of the tumor‐infiltrating immune cells, including activated CD8+ T cells and PD‐L1 expression, suggesting an immunologically hot tumor. Conclusion Combination immunotherapy was a viable treatment option for this disease. Immunohistochemical analyses of the tumor‐infiltrating immune cells predicted the efficacy of immune checkpoint inhibitors against rare renal cancers. |
| first_indexed | 2024-12-21T23:11:02Z |
| format | Article |
| id | doaj.art-ff1b36ac8c024ea99466c665303b8eb6 |
| institution | Directory Open Access Journal |
| issn | 2577-171X |
| language | English |
| last_indexed | 2024-12-21T23:11:02Z |
| publishDate | 2021-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | IJU Case Reports |
| spelling | doaj.art-ff1b36ac8c024ea99466c665303b8eb62022-12-21T18:47:03ZengWileyIJU Case Reports2577-171X2021-09-014533333710.1002/iju5.12342Metastatic mucinous tubular and spindle cell carcinoma of the kidney responding to nivolumab plus ipilimumabHirotaka Fuchizawa0Toshiki Kijima1Atsuko Takada‐Owada2Yoji Nagashima3Akihito Okazaki4Megumi Yokoyama5Daisaku Nishihara6Kazuyuki Ishida7Takao Kamai8Department of Urology Dokkyo Medical University ShimotsugaTochigiJapanDepartment of Urology Dokkyo Medical University ShimotsugaTochigiJapanDepartment ofDiagnostic Pathology Dokkyo Medical University Shimotsuga TochigiJapanDepartment of Surgical Pathology Tokyo Women’s Medical University Tokyo JapanDepartment of Urology Dokkyo Medical University ShimotsugaTochigiJapanDepartment of Urology Dokkyo Medical University ShimotsugaTochigiJapanDepartment of Urology Dokkyo Medical University ShimotsugaTochigiJapanDepartment ofDiagnostic Pathology Dokkyo Medical University Shimotsuga TochigiJapanDepartment of Urology Dokkyo Medical University ShimotsugaTochigiJapanIntroduction Mucinous tubular and spindle cell carcinoma is a rare subtype of renal cell carcinoma. Little is known regarding the efficacy of systemic therapy on its metastatic form because of its rarity. Case presentation We present the case of a patient with metastatic mucinous tubular and spindle cell carcinoma who achieved durable complete remission of multiple osseous metastases after undergoing cytoreductive nephrectomy followed by combination immunotherapy (ipilimumab plus nivolumab). Immunohistochemical analyses of the primary tumor revealed the presence of the tumor‐infiltrating immune cells, including activated CD8+ T cells and PD‐L1 expression, suggesting an immunologically hot tumor. Conclusion Combination immunotherapy was a viable treatment option for this disease. Immunohistochemical analyses of the tumor‐infiltrating immune cells predicted the efficacy of immune checkpoint inhibitors against rare renal cancers.https://doi.org/10.1002/iju5.12342cytoreductive surgeryimmunotherapymucinous tubular and spindle cell carcinomanephrectomyrenal cell carcinoma |
| spellingShingle | Hirotaka Fuchizawa Toshiki Kijima Atsuko Takada‐Owada Yoji Nagashima Akihito Okazaki Megumi Yokoyama Daisaku Nishihara Kazuyuki Ishida Takao Kamai Metastatic mucinous tubular and spindle cell carcinoma of the kidney responding to nivolumab plus ipilimumab IJU Case Reports cytoreductive surgery immunotherapy mucinous tubular and spindle cell carcinoma nephrectomy renal cell carcinoma |
| title | Metastatic mucinous tubular and spindle cell carcinoma of the kidney responding to nivolumab plus ipilimumab |
| title_full | Metastatic mucinous tubular and spindle cell carcinoma of the kidney responding to nivolumab plus ipilimumab |
| title_fullStr | Metastatic mucinous tubular and spindle cell carcinoma of the kidney responding to nivolumab plus ipilimumab |
| title_full_unstemmed | Metastatic mucinous tubular and spindle cell carcinoma of the kidney responding to nivolumab plus ipilimumab |
| title_short | Metastatic mucinous tubular and spindle cell carcinoma of the kidney responding to nivolumab plus ipilimumab |
| title_sort | metastatic mucinous tubular and spindle cell carcinoma of the kidney responding to nivolumab plus ipilimumab |
| topic | cytoreductive surgery immunotherapy mucinous tubular and spindle cell carcinoma nephrectomy renal cell carcinoma |
| url | https://doi.org/10.1002/iju5.12342 |
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