Impact of ROS-Dependent Lipid Metabolism on Psoriasis Pathophysiology
Psoriasis is the most common autoimmune disease, yet its pathophysiology is not fully understood. It is now believed that psoriasis is caused by the increased activation of immune cells, especially Th1 lymphocytes. However, in psoriasis, immune cells interfere with the metabolism of keratinocytes, l...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/20/12137 |
| _version_ | 1797407211268341760 |
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| author | Adam Wroński Piotr Wójcik |
| author_facet | Adam Wroński Piotr Wójcik |
| author_sort | Adam Wroński |
| collection | DOAJ |
| description | Psoriasis is the most common autoimmune disease, yet its pathophysiology is not fully understood. It is now believed that psoriasis is caused by the increased activation of immune cells, especially Th1 lymphocytes. However, in psoriasis, immune cells interfere with the metabolism of keratinocytes, leading to their increased activation. Therefore, the pathophysiology of psoriasis is currently associated with the overproduction of ROS, which are involved in the activation of immune cells and keratinocytes as well as the modulation of various signaling pathways within them. Nevertheless, ROS modulate the immune system by also boosting the increasing generation of various lipid mediators, such as products of lipid peroxidation as well as endocannabinoids and prostaglandins. In psoriasis, the excessive generation of ROS and lipid mediators is observed in different immune cells, such as granulocytes, dendritic cells, and lymphocytes. All of the above may be activated by ROS and lipid mediators, which leads to inflammation. Nevertheless, ROS and lipid mediators regulate lymphocyte differentiation in favor of Th1 and may also interact directly with keratinocytes, which is also observed in psoriasis. Thus, the analysis of the influence of oxidative stress and its consequences for metabolic changes, including lipidomic ones, in psoriasis may be of diagnostic and therapeutic importance. |
| first_indexed | 2024-03-09T03:38:02Z |
| format | Article |
| id | doaj.art-ff1d131c1c994358917c4b20c325a68a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T03:38:02Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ff1d131c1c994358917c4b20c325a68a2023-12-03T14:46:28ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123201213710.3390/ijms232012137Impact of ROS-Dependent Lipid Metabolism on Psoriasis PathophysiologyAdam Wroński0Piotr Wójcik1Dermatological Specialized Center “DERMAL” NZOZ in Bialystok, 15-453 Bialystok, PolandDepartment of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, PolandPsoriasis is the most common autoimmune disease, yet its pathophysiology is not fully understood. It is now believed that psoriasis is caused by the increased activation of immune cells, especially Th1 lymphocytes. However, in psoriasis, immune cells interfere with the metabolism of keratinocytes, leading to their increased activation. Therefore, the pathophysiology of psoriasis is currently associated with the overproduction of ROS, which are involved in the activation of immune cells and keratinocytes as well as the modulation of various signaling pathways within them. Nevertheless, ROS modulate the immune system by also boosting the increasing generation of various lipid mediators, such as products of lipid peroxidation as well as endocannabinoids and prostaglandins. In psoriasis, the excessive generation of ROS and lipid mediators is observed in different immune cells, such as granulocytes, dendritic cells, and lymphocytes. All of the above may be activated by ROS and lipid mediators, which leads to inflammation. Nevertheless, ROS and lipid mediators regulate lymphocyte differentiation in favor of Th1 and may also interact directly with keratinocytes, which is also observed in psoriasis. Thus, the analysis of the influence of oxidative stress and its consequences for metabolic changes, including lipidomic ones, in psoriasis may be of diagnostic and therapeutic importance.https://www.mdpi.com/1422-0067/23/20/12137psoriasislipid mediatorsROSeicosanoidsendocannabinoidslymphocytes |
| spellingShingle | Adam Wroński Piotr Wójcik Impact of ROS-Dependent Lipid Metabolism on Psoriasis Pathophysiology International Journal of Molecular Sciences psoriasis lipid mediators ROS eicosanoids endocannabinoids lymphocytes |
| title | Impact of ROS-Dependent Lipid Metabolism on Psoriasis Pathophysiology |
| title_full | Impact of ROS-Dependent Lipid Metabolism on Psoriasis Pathophysiology |
| title_fullStr | Impact of ROS-Dependent Lipid Metabolism on Psoriasis Pathophysiology |
| title_full_unstemmed | Impact of ROS-Dependent Lipid Metabolism on Psoriasis Pathophysiology |
| title_short | Impact of ROS-Dependent Lipid Metabolism on Psoriasis Pathophysiology |
| title_sort | impact of ros dependent lipid metabolism on psoriasis pathophysiology |
| topic | psoriasis lipid mediators ROS eicosanoids endocannabinoids lymphocytes |
| url | https://www.mdpi.com/1422-0067/23/20/12137 |
| work_keys_str_mv | AT adamwronski impactofrosdependentlipidmetabolismonpsoriasispathophysiology AT piotrwojcik impactofrosdependentlipidmetabolismonpsoriasispathophysiology |