Correlation between non-breathing-related sleep fragmentation and asymptomatic cerebral small vessel disease
Objective To investigate the potential correlation between non-breathing-related sleep fragmentation and cerebral small vessel disease(CSVD). Methods A total of 124 cases were collected from patients hospitalized in Second Affiliated Hospital of Dalian Medical University from September 2019 to Septe...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2022-02-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-2-286.pdf |
| _version_ | 1797365895363821568 |
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| author | LI Li, LU Zi-yi, LIU Jia-ling, LIU Li-mei |
| author_facet | LI Li, LU Zi-yi, LIU Jia-ling, LIU Li-mei |
| author_sort | LI Li, LU Zi-yi, LIU Jia-ling, LIU Li-mei |
| collection | DOAJ |
| description | Objective To investigate the potential correlation between non-breathing-related sleep fragmentation and cerebral small vessel disease(CSVD). Methods A total of 124 cases were collected from patients hospitalized in Second Affiliated Hospital of Dalian Medical University from September 2019 to September 2021. After completing the cerebral magnetic resonance plain scan(MRI+MRA+DWI+FLAIR)and risk factor screening, the patients completed the mobile sleep respiration monitoring,cardiopulmonary coupling map(CPC), excluding respiratory related sleep disorders, patients with CSVD were taken as the experimental group (70 cases) and patients without CSVD as the control group (54 cases). Sleep monitoring data between the two groups were compared,including total sleep time (TST), sleep latency (SL), stable sleep duration (stable), unstable sleep duration (unstable),rapid eyes movement duration(REM), arousal index(ArI), sleep efficiency (SE) and apnea hypopnea index (AHI). Results ArI in the experimental group (30.00±10.06 times) was significantly higher than that in the control group (25.61±9.42 times)(P＜0.05). The median AHI in the experimental group was 5.75(2.65-9.10)times/hour, significantly higher than that in the control group(P＜0.05). The median duration of Stable was 45.75(19.38-91.13) min in the experimental group,remarkably lower than 76.50(35.5-102.9) min in the control group(P＜0.05). The median Stable proportion in the experimental group was 12.70%(6.23%-22.50%), markedly lower than that in the control group, 19.4%(8.78%-27.90%)(P＜0.05). After adjusting for age, hypertension, and diabetes, ArI was an independent risk factor for CSVD (OR=1.098, 95% CI:1.022-1.180)(P＜0.05). Conclusions Non-breathing-related sleep fragmentation increases the risk of asymptomatic CSVD. |
| first_indexed | 2024-03-08T16:56:27Z |
| format | Article |
| id | doaj.art-ff1de8fe7e064cbc9c8aee34cc88a0a4 |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:56:27Z |
| publishDate | 2022-02-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-ff1de8fe7e064cbc9c8aee34cc88a0a42024-01-05T02:34:11ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252022-02-0142228629010.16352/j.issn.1001-6325.2022.02.008Correlation between non-breathing-related sleep fragmentation and asymptomatic cerebral small vessel diseaseLI Li, LU Zi-yi, LIU Jia-ling, LIU Li-mei0Department of Neurology, the Second Affiliated Hospital of Dalian Medical University,Dalian 116023,ChinaObjective To investigate the potential correlation between non-breathing-related sleep fragmentation and cerebral small vessel disease(CSVD). Methods A total of 124 cases were collected from patients hospitalized in Second Affiliated Hospital of Dalian Medical University from September 2019 to September 2021. After completing the cerebral magnetic resonance plain scan(MRI+MRA+DWI+FLAIR)and risk factor screening, the patients completed the mobile sleep respiration monitoring,cardiopulmonary coupling map(CPC), excluding respiratory related sleep disorders, patients with CSVD were taken as the experimental group (70 cases) and patients without CSVD as the control group (54 cases). Sleep monitoring data between the two groups were compared,including total sleep time (TST), sleep latency (SL), stable sleep duration (stable), unstable sleep duration (unstable),rapid eyes movement duration(REM), arousal index(ArI), sleep efficiency (SE) and apnea hypopnea index (AHI). Results ArI in the experimental group (30.00±10.06 times) was significantly higher than that in the control group (25.61±9.42 times)(P＜0.05). The median AHI in the experimental group was 5.75(2.65-9.10)times/hour, significantly higher than that in the control group(P＜0.05). The median duration of Stable was 45.75(19.38-91.13) min in the experimental group,remarkably lower than 76.50(35.5-102.9) min in the control group(P＜0.05). The median Stable proportion in the experimental group was 12.70%(6.23%-22.50%), markedly lower than that in the control group, 19.4%(8.78%-27.90%)(P＜0.05). After adjusting for age, hypertension, and diabetes, ArI was an independent risk factor for CSVD (OR=1.098, 95% CI:1.022-1.180)(P＜0.05). Conclusions Non-breathing-related sleep fragmentation increases the risk of asymptomatic CSVD.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-2-286.pdfsleep|sleep fragementation|arousal index|cerebral small vessel disease|cardiopulmonary coupling(cpc) |
| spellingShingle | LI Li, LU Zi-yi, LIU Jia-ling, LIU Li-mei Correlation between non-breathing-related sleep fragmentation and asymptomatic cerebral small vessel disease Jichu yixue yu linchuang sleep|sleep fragementation|arousal index|cerebral small vessel disease|cardiopulmonary coupling(cpc) |
| title | Correlation between non-breathing-related sleep fragmentation and asymptomatic cerebral small vessel disease |
| title_full | Correlation between non-breathing-related sleep fragmentation and asymptomatic cerebral small vessel disease |
| title_fullStr | Correlation between non-breathing-related sleep fragmentation and asymptomatic cerebral small vessel disease |
| title_full_unstemmed | Correlation between non-breathing-related sleep fragmentation and asymptomatic cerebral small vessel disease |
| title_short | Correlation between non-breathing-related sleep fragmentation and asymptomatic cerebral small vessel disease |
| title_sort | correlation between non breathing related sleep fragmentation and asymptomatic cerebral small vessel disease |
| topic | sleep|sleep fragementation|arousal index|cerebral small vessel disease|cardiopulmonary coupling(cpc) |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-2-286.pdf |
| work_keys_str_mv | AT lililuziyiliujialingliulimei correlationbetweennonbreathingrelatedsleepfragmentationandasymptomaticcerebralsmallvesseldisease |