Basal cortisol levels and the relationship with clinical symptoms in multiple sclerosis: a systematic review
ABSTRACT Multiple sclerosis (MS) is a demyelinating, progressive and neurodegenerative disease. A disturbance on the hypothalamic-pituitary-adrenal axis can be observed in patients with MS, showing altered cortisol levels. We aimed to identify basal cortisol levels and verify the relationship with c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000900622&lng=en&tlng=en |
| _version_ | 1818590571388731392 |
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| author | Gabriela Magalhães Pereira Nayron Medeiros Soares Andreo Rysdyk de Souza Jefferson Becker Alessandro Finkelsztejn Rosa Maria Martins de Almeida |
| author_facet | Gabriela Magalhães Pereira Nayron Medeiros Soares Andreo Rysdyk de Souza Jefferson Becker Alessandro Finkelsztejn Rosa Maria Martins de Almeida |
| author_sort | Gabriela Magalhães Pereira |
| collection | DOAJ |
| description | ABSTRACT Multiple sclerosis (MS) is a demyelinating, progressive and neurodegenerative disease. A disturbance on the hypothalamic-pituitary-adrenal axis can be observed in patients with MS, showing altered cortisol levels. We aimed to identify basal cortisol levels and verify the relationship with clinical symptoms in patients with MS. A systematic search was conducted in the databases: Pubmed, Web of Science and SCOPUS. Both higher and lower cortisol levels were associated with MS. Higher cortisol levels were associated with depression and anxiety, while lower levels were associated with depression, fatigue and urinary dysfunction. Higher cortisol levels may be associated with the progression and severity of MS. |
| first_indexed | 2024-12-16T09:58:39Z |
| format | Article |
| id | doaj.art-ff1f152009e2421da7cb755702e865d0 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-16T09:58:39Z |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-ff1f152009e2421da7cb755702e865d02022-12-21T22:35:51ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-422776962263410.1590/0004-282x20180091S0004-282X2018000900622Basal cortisol levels and the relationship with clinical symptoms in multiple sclerosis: a systematic reviewGabriela Magalhães PereiraNayron Medeiros SoaresAndreo Rysdyk de SouzaJefferson BeckerAlessandro FinkelsztejnRosa Maria Martins de AlmeidaABSTRACT Multiple sclerosis (MS) is a demyelinating, progressive and neurodegenerative disease. A disturbance on the hypothalamic-pituitary-adrenal axis can be observed in patients with MS, showing altered cortisol levels. We aimed to identify basal cortisol levels and verify the relationship with clinical symptoms in patients with MS. A systematic search was conducted in the databases: Pubmed, Web of Science and SCOPUS. Both higher and lower cortisol levels were associated with MS. Higher cortisol levels were associated with depression and anxiety, while lower levels were associated with depression, fatigue and urinary dysfunction. Higher cortisol levels may be associated with the progression and severity of MS.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000900622&lng=en&tlng=enMultiple sclerosishydrocortisonepituitary-adrenal systemneurologic manifestationsgeneral symptoms |
| spellingShingle | Gabriela Magalhães Pereira Nayron Medeiros Soares Andreo Rysdyk de Souza Jefferson Becker Alessandro Finkelsztejn Rosa Maria Martins de Almeida Basal cortisol levels and the relationship with clinical symptoms in multiple sclerosis: a systematic review Arquivos de Neuro-Psiquiatria Multiple sclerosis hydrocortisone pituitary-adrenal system neurologic manifestations general symptoms |
| title | Basal cortisol levels and the relationship with clinical symptoms in multiple sclerosis: a systematic review |
| title_full | Basal cortisol levels and the relationship with clinical symptoms in multiple sclerosis: a systematic review |
| title_fullStr | Basal cortisol levels and the relationship with clinical symptoms in multiple sclerosis: a systematic review |
| title_full_unstemmed | Basal cortisol levels and the relationship with clinical symptoms in multiple sclerosis: a systematic review |
| title_short | Basal cortisol levels and the relationship with clinical symptoms in multiple sclerosis: a systematic review |
| title_sort | basal cortisol levels and the relationship with clinical symptoms in multiple sclerosis a systematic review |
| topic | Multiple sclerosis hydrocortisone pituitary-adrenal system neurologic manifestations general symptoms |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000900622&lng=en&tlng=en |
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