The neuroprotective role of Wnt signaling in the retina
The canonical Wnt/β-catenin signaling pathway has been shown to play a major role during embryonic development and maturation of the central nervous system including the retina. It has a significant impact on retinal vessel formation and maturation, as well as on the establishment of synaptic struct...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2021-01-01
|
| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=8;spage=1524;epage=1528;aulast=Kassumeh |
| _version_ | 1818390091771412480 |
|---|---|
| author | Stefan Kassumeh Gregor R Weber Matthias Nobl Siegfried G Priglinger Andreas Ohlmann |
| author_facet | Stefan Kassumeh Gregor R Weber Matthias Nobl Siegfried G Priglinger Andreas Ohlmann |
| author_sort | Stefan Kassumeh |
| collection | DOAJ |
| description | The canonical Wnt/β-catenin signaling pathway has been shown to play a major role during embryonic development and maturation of the central nervous system including the retina. It has a significant impact on retinal vessel formation and maturation, as well as on the establishment of synaptic structures and neuronal function in the central nervous system. Mutations in components of the Wnt/β-catenin signaling cascade may lead to severe retinal diseases, while dysregulation of Wnt signaling can contribute to disease progression. Apart from the angiogenic role of Wnt/β-catenin signaling, research in the last decades leads to the theory of a protective effect of Wnt/β-catenin signaling on damaged neurons. In this review, we focus on the neuroprotective properties of the Wnt/β-catenin pathway as well as its downstream signaling in the retina. |
| first_indexed | 2024-12-14T04:52:07Z |
| format | Article |
| id | doaj.art-ff1f2c36104544f1b405dfd02596fd63 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-14T04:52:07Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-ff1f2c36104544f1b405dfd02596fd632022-12-21T23:16:32ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742021-01-011681524152810.4103/1673-5374.303010The neuroprotective role of Wnt signaling in the retinaStefan KassumehGregor R WeberMatthias NoblSiegfried G PriglingerAndreas OhlmannThe canonical Wnt/β-catenin signaling pathway has been shown to play a major role during embryonic development and maturation of the central nervous system including the retina. It has a significant impact on retinal vessel formation and maturation, as well as on the establishment of synaptic structures and neuronal function in the central nervous system. Mutations in components of the Wnt/β-catenin signaling cascade may lead to severe retinal diseases, while dysregulation of Wnt signaling can contribute to disease progression. Apart from the angiogenic role of Wnt/β-catenin signaling, research in the last decades leads to the theory of a protective effect of Wnt/β-catenin signaling on damaged neurons. In this review, we focus on the neuroprotective properties of the Wnt/β-catenin pathway as well as its downstream signaling in the retina.http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=8;spage=1524;epage=1528;aulast=Kassumehapoptosis; β-catenin; leukemia inhibitory factor; müller cells; neurodegeneration; neuroprotection; norrin; photoreceptors; retina; retinal ganglion cells; wnt |
| spellingShingle | Stefan Kassumeh Gregor R Weber Matthias Nobl Siegfried G Priglinger Andreas Ohlmann The neuroprotective role of Wnt signaling in the retina Neural Regeneration Research apoptosis; β-catenin; leukemia inhibitory factor; müller cells; neurodegeneration; neuroprotection; norrin; photoreceptors; retina; retinal ganglion cells; wnt |
| title | The neuroprotective role of Wnt signaling in the retina |
| title_full | The neuroprotective role of Wnt signaling in the retina |
| title_fullStr | The neuroprotective role of Wnt signaling in the retina |
| title_full_unstemmed | The neuroprotective role of Wnt signaling in the retina |
| title_short | The neuroprotective role of Wnt signaling in the retina |
| title_sort | neuroprotective role of wnt signaling in the retina |
| topic | apoptosis; β-catenin; leukemia inhibitory factor; müller cells; neurodegeneration; neuroprotection; norrin; photoreceptors; retina; retinal ganglion cells; wnt |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=8;spage=1524;epage=1528;aulast=Kassumeh |
| work_keys_str_mv | AT stefankassumeh theneuroprotectiveroleofwntsignalingintheretina AT gregorrweber theneuroprotectiveroleofwntsignalingintheretina AT matthiasnobl theneuroprotectiveroleofwntsignalingintheretina AT siegfriedgpriglinger theneuroprotectiveroleofwntsignalingintheretina AT andreasohlmann theneuroprotectiveroleofwntsignalingintheretina AT stefankassumeh neuroprotectiveroleofwntsignalingintheretina AT gregorrweber neuroprotectiveroleofwntsignalingintheretina AT matthiasnobl neuroprotectiveroleofwntsignalingintheretina AT siegfriedgpriglinger neuroprotectiveroleofwntsignalingintheretina AT andreasohlmann neuroprotectiveroleofwntsignalingintheretina |