Can polydatin have a beneficial role against bisphenol an exposure in rats?
The present study was conducted to evaluate the effects of chronic bisphenol A (BPA) exposure and the possible protective effects of polydatin (PD) on different organs, oxidant-antioxidant status and spermatological parameters in male Wistar rats. Male Wistar rats (2 to 3 months old) were randomly...
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| Format: | Article |
| Language: | English |
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Prince of Songkla University
2022-02-01
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| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | https://rdo.psu.ac.th/sjst/journal/44-1/32.pdf |
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| author | Recep Aslan Hasan Hüseyin Fatih Avdatek Aziz Bülbül Abdullah Eryavuz Mehmet Şükrü Gulay |
| author_facet | Recep Aslan Hasan Hüseyin Fatih Avdatek Aziz Bülbül Abdullah Eryavuz Mehmet Şükrü Gulay |
| author_sort | Recep Aslan |
| collection | DOAJ |
| description | The present study was conducted to evaluate the effects of chronic bisphenol A (BPA) exposure and the possible
protective effects of polydatin (PD) on different organs, oxidant-antioxidant status and spermatological parameters in male
Wistar rats. Male Wistar rats (2 to 3 months old) were randomly divided into 5 groups (n = 6). Group 1 was the control (daily
0.5ml distilled water). Groups 2, 3, 4 and 5 daily received 0.5 ml olive oil (OO), 25 mg/kg bisphenol A in 0.5 olive oil (BPA),
150 mg/kg polydatin (PD), and a mixture of 25 mg/kg bisphenol A in 0.5 olive oil + 150 mg/kg polydatin (BPA-PD),
respectively, daily for 45 days. BPA had negative effects on percent abnormal sperm and Hypo-osmotic swelling-Eosin (HE) test
(P<0.01). BPA caused negative histopathological alterations to the brain, heart, liver, kidney, and testis tissues. PD
administration was able to ameliorate the negative effects of BPA. Moreover, PD had positive effects on percent motility
(P<0.02), head defects of sperm (P<0.01), and HE test (P<0.01) when compared to the controls. The results indicate that PD
decreases BPA-induced sperm defects and repaired tissue damage in the various organs in rats. |
| first_indexed | 2024-04-12T13:06:32Z |
| format | Article |
| id | doaj.art-ff1f375d095f4c35b653498eabf70ac3 |
| institution | Directory Open Access Journal |
| issn | 0125-3395 |
| language | English |
| last_indexed | 2024-04-12T13:06:32Z |
| publishDate | 2022-02-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Songklanakarin Journal of Science and Technology (SJST) |
| spelling | doaj.art-ff1f375d095f4c35b653498eabf70ac32022-12-22T03:32:00ZengPrince of Songkla UniversitySongklanakarin Journal of Science and Technology (SJST)0125-33952022-02-0144122323010.14456/sjst-psu.2022.32Can polydatin have a beneficial role against bisphenol an exposure in rats?Recep Aslan0Hasan Hüseyin1Fatih Avdatek2Aziz Bülbül3Abdullah Eryavuz4Mehmet Şükrü Gulay5Department of Physiology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, 03200 TurkeyBayat Vocational School, Afyon Kocatepe University, Afyonkarahisar, 03200 TurkeyDepartment of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, 03200 TurkeyDepartment of Physiology, Faculty of Veterinary Medicine, Muğla Sıtkı Kocman University, Muğla, Milas, 48000 TurkeyDepartment of Physiology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, 03200 TurkeyDepartment of Physiology, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University, Burdur, 15030 TurkeyThe present study was conducted to evaluate the effects of chronic bisphenol A (BPA) exposure and the possible protective effects of polydatin (PD) on different organs, oxidant-antioxidant status and spermatological parameters in male Wistar rats. Male Wistar rats (2 to 3 months old) were randomly divided into 5 groups (n = 6). Group 1 was the control (daily 0.5ml distilled water). Groups 2, 3, 4 and 5 daily received 0.5 ml olive oil (OO), 25 mg/kg bisphenol A in 0.5 olive oil (BPA), 150 mg/kg polydatin (PD), and a mixture of 25 mg/kg bisphenol A in 0.5 olive oil + 150 mg/kg polydatin (BPA-PD), respectively, daily for 45 days. BPA had negative effects on percent abnormal sperm and Hypo-osmotic swelling-Eosin (HE) test (P<0.01). BPA caused negative histopathological alterations to the brain, heart, liver, kidney, and testis tissues. PD administration was able to ameliorate the negative effects of BPA. Moreover, PD had positive effects on percent motility (P<0.02), head defects of sperm (P<0.01), and HE test (P<0.01) when compared to the controls. The results indicate that PD decreases BPA-induced sperm defects and repaired tissue damage in the various organs in rats.https://rdo.psu.ac.th/sjst/journal/44-1/32.pdfbpa toxicityoxidative stresspolydatinspermatological parameters |
| spellingShingle | Recep Aslan Hasan Hüseyin Fatih Avdatek Aziz Bülbül Abdullah Eryavuz Mehmet Şükrü Gulay Can polydatin have a beneficial role against bisphenol an exposure in rats? Songklanakarin Journal of Science and Technology (SJST) bpa toxicity oxidative stress polydatin spermatological parameters |
| title | Can polydatin have a beneficial role against bisphenol an exposure in rats? |
| title_full | Can polydatin have a beneficial role against bisphenol an exposure in rats? |
| title_fullStr | Can polydatin have a beneficial role against bisphenol an exposure in rats? |
| title_full_unstemmed | Can polydatin have a beneficial role against bisphenol an exposure in rats? |
| title_short | Can polydatin have a beneficial role against bisphenol an exposure in rats? |
| title_sort | can polydatin have a beneficial role against bisphenol an exposure in rats |
| topic | bpa toxicity oxidative stress polydatin spermatological parameters |
| url | https://rdo.psu.ac.th/sjst/journal/44-1/32.pdf |
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