Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma?
Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. We aimed to compare the performance of SUV<sub>max</sub> reduction (ΔSUV<sub>max%</sub>) and the PET ratio (rPET) versus the Deauville score (DS)...
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MDPI AG
2023-02-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/3/445 |
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| author | Firuz Ibrahim Michela Gabelloni Lorenzo Faggioni Subramanyam Padma Arun R. Visakh Dania Cioni Emanuele Neri |
| author_facet | Firuz Ibrahim Michela Gabelloni Lorenzo Faggioni Subramanyam Padma Arun R. Visakh Dania Cioni Emanuele Neri |
| author_sort | Firuz Ibrahim |
| collection | DOAJ |
| description | Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. We aimed to compare the performance of SUV<sub>max</sub> reduction (ΔSUV<sub>max%</sub>) and the PET ratio (rPET) versus the Deauville score (DS) for assessing the chemotherapy response in pediatric HL patients undergoing <sup>18</sup>F-FDG PET-CT. Fifty-two patients with biopsy-proven HL (aged 8–16 years) were enrolled at baseline, interim (after the second or third chemotherapy round) and post-therapy (on completion of first-line chemotherapy). Interim and post-therapy DS, ΔSUV<sub>max%</sub> and rPET were compared as response predictors. Patients were classified as responders or non-responders based on a 24-month clinical follow-up. Interim DS showed a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of 100%, 80.4%, 100%, 40% and 82.7%, respectively, in predicting the therapy response. Post-therapy DS showed a sensitivity, specificity, PPV, NPV and accuracy of 66.7%, 97.8%, 95.7%, 80% and 94.2%, repsectively. Interim ΔSUV<sub>max%</sub> showed a sensitivity, specificity, PPV, NPV and accuracy of 83.3%, 82.6%, 97.4%, 38.5% and 82.7%, respectively, with a 56.3% cutoff. Post-therapy ΔSUV<sub>max%</sub> showed a sensitivity, specificity, PPV, NPV and accuracy of 83.3%, 84.8%, 97.5%, 41.7% and 84.6%, respectively, with a 76.8% cutoff. Compared to ΔSUV<sub>max%</sub>, DS showed a significantly higher sensitivity, specificity (<i>p</i> < 0.05) and NPV (<i>p</i> < 0.01). The sensitivity, specificity, PPV, NPV and accuracy of rPET in predicting the therapy response at 24 months were 76.1%, 100%, 100%, 35.3% and 78.8%, respectively, with a cut-off of 1.31. DS and rPET showed comparable predictive performance (<i>p</i> > 0.58). In conclusion, DS is an easier method with better performance than ΔSUV<sub>max%</sub> and rPET in predicting the chemotherapy response in pediatric HL patients. |
| first_indexed | 2024-03-11T06:19:44Z |
| format | Article |
| id | doaj.art-ff20888185764302b66478d76eb26b92 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T06:19:44Z |
| publishDate | 2023-02-01 |
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| record_format | Article |
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| spelling | doaj.art-ff20888185764302b66478d76eb26b922023-11-17T12:02:27ZengMDPI AGJournal of Personalized Medicine2075-44262023-02-0113344510.3390/jpm13030445Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma?Firuz Ibrahim0Michela Gabelloni1Lorenzo Faggioni2Subramanyam Padma3Arun R. Visakh4Dania Cioni5Emanuele Neri6Department of Nuclear Medicine and PET-CT, Burjeel Medical City, Abu Dhabi 92510, United Arab EmiratesAcademic Radiology, Department of Translational Research, University of Pisa, 56126 Pisa, ItalyAcademic Radiology, Department of Translational Research, University of Pisa, 56126 Pisa, ItalyAmrita Institute of Medical Sciences, Kochi 682041, Kerala, IndiaDepartment of Nuclear Medicine, VPS Lakeshore Hospital, Kochi 682040, Kerala, IndiaAcademic Radiology, Department of Translational Research, University of Pisa, 56126 Pisa, ItalyAcademic Radiology, Department of Translational Research, University of Pisa, 56126 Pisa, ItalyTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. We aimed to compare the performance of SUV<sub>max</sub> reduction (ΔSUV<sub>max%</sub>) and the PET ratio (rPET) versus the Deauville score (DS) for assessing the chemotherapy response in pediatric HL patients undergoing <sup>18</sup>F-FDG PET-CT. Fifty-two patients with biopsy-proven HL (aged 8–16 years) were enrolled at baseline, interim (after the second or third chemotherapy round) and post-therapy (on completion of first-line chemotherapy). Interim and post-therapy DS, ΔSUV<sub>max%</sub> and rPET were compared as response predictors. Patients were classified as responders or non-responders based on a 24-month clinical follow-up. Interim DS showed a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of 100%, 80.4%, 100%, 40% and 82.7%, respectively, in predicting the therapy response. Post-therapy DS showed a sensitivity, specificity, PPV, NPV and accuracy of 66.7%, 97.8%, 95.7%, 80% and 94.2%, repsectively. Interim ΔSUV<sub>max%</sub> showed a sensitivity, specificity, PPV, NPV and accuracy of 83.3%, 82.6%, 97.4%, 38.5% and 82.7%, respectively, with a 56.3% cutoff. Post-therapy ΔSUV<sub>max%</sub> showed a sensitivity, specificity, PPV, NPV and accuracy of 83.3%, 84.8%, 97.5%, 41.7% and 84.6%, respectively, with a 76.8% cutoff. Compared to ΔSUV<sub>max%</sub>, DS showed a significantly higher sensitivity, specificity (<i>p</i> < 0.05) and NPV (<i>p</i> < 0.01). The sensitivity, specificity, PPV, NPV and accuracy of rPET in predicting the therapy response at 24 months were 76.1%, 100%, 100%, 35.3% and 78.8%, respectively, with a cut-off of 1.31. DS and rPET showed comparable predictive performance (<i>p</i> > 0.58). In conclusion, DS is an easier method with better performance than ΔSUV<sub>max%</sub> and rPET in predicting the chemotherapy response in pediatric HL patients.https://www.mdpi.com/2075-4426/13/3/445Hodgkin lymphomachemotherapypositron emission tomography computed tomography (PET-CT)[18F]fluoro-2-deoxy-2-D-glucose (<sup>18</sup>F-FDG)Deauville scorestandardized uptake value (SUV) |
| spellingShingle | Firuz Ibrahim Michela Gabelloni Lorenzo Faggioni Subramanyam Padma Arun R. Visakh Dania Cioni Emanuele Neri Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma? Journal of Personalized Medicine Hodgkin lymphoma chemotherapy positron emission tomography computed tomography (PET-CT) [18F]fluoro-2-deoxy-2-D-glucose (<sup>18</sup>F-FDG) Deauville score standardized uptake value (SUV) |
| title | Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma? |
| title_full | Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma? |
| title_fullStr | Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma? |
| title_full_unstemmed | Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma? |
| title_short | Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma? |
| title_sort | are semiquantitative methods superior to deauville scoring in the monitoring therapy response for pediatric hodgkin lymphoma |
| topic | Hodgkin lymphoma chemotherapy positron emission tomography computed tomography (PET-CT) [18F]fluoro-2-deoxy-2-D-glucose (<sup>18</sup>F-FDG) Deauville score standardized uptake value (SUV) |
| url | https://www.mdpi.com/2075-4426/13/3/445 |
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