Feasibility of Wave Intensity Analysis from 4D Cardiovascular Magnetic Resonance Imaging Data
Congenital heart defects (CHD) introduce haemodynamic changes; e.g., bicuspid aortic valve (BAV) presents a turbulent helical flow, which activates aortic pathological processes. Flow quantification is crucial for diagnostics and to plan corrective strategies. Multiple imaging modalities exist, with...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/10/6/662 |
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| author | Froso Sophocleous Kiril Delchev Estefania De Garate Mark C. K. Hamilton Massimo Caputo Chiara Bucciarelli-Ducci Giovanni Biglino |
| author_facet | Froso Sophocleous Kiril Delchev Estefania De Garate Mark C. K. Hamilton Massimo Caputo Chiara Bucciarelli-Ducci Giovanni Biglino |
| author_sort | Froso Sophocleous |
| collection | DOAJ |
| description | Congenital heart defects (CHD) introduce haemodynamic changes; e.g., bicuspid aortic valve (BAV) presents a turbulent helical flow, which activates aortic pathological processes. Flow quantification is crucial for diagnostics and to plan corrective strategies. Multiple imaging modalities exist, with phase contrast magnetic resonance imaging (PC-MRI) being the current gold standard; however, multiple predetermined site measurements may be required, while 4D MRI allows for measurements of area (A) and velocity (U) in all spatial dimensions, acquiring a single volume and enabling a retrospective analysis at multiple locations. We assessed the feasibility of gathering hemodynamic insight into aortic hemodynamics by means of wave intensity analysis (WIA) derived from 4D MRI. Data were collected in <i>n</i> = 12 BAV patients and <i>n</i> = 7 healthy controls. Following data acquisition, WIA was successfully derived at three planes (ascending, thoracic and descending aorta) in all cases. The values of wave speed were physiological and, while the small sample limited any clinical interpretation of the results, the study shows the possibility of studying wave travel and wave reflection based on 4D MRI. Below, we demonstrate for the first time the feasibility of deriving wave intensity analysis from 4D flow data and open the door to research applications in different cardiovascular scenarios. |
| first_indexed | 2024-03-11T02:46:23Z |
| format | Article |
| id | doaj.art-ff22d85ce32d42acb1e0458fd4b55dae |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-11T02:46:23Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-ff22d85ce32d42acb1e0458fd4b55dae2023-11-18T09:21:02ZengMDPI AGBioengineering2306-53542023-05-0110666210.3390/bioengineering10060662Feasibility of Wave Intensity Analysis from 4D Cardiovascular Magnetic Resonance Imaging DataFroso Sophocleous0Kiril Delchev1Estefania De Garate2Mark C. K. Hamilton3Massimo Caputo4Chiara Bucciarelli-Ducci5Giovanni Biglino6Bristol Heart Institute, Bristol Medical School, University of Bristol, Bristol BS8 1QU, UKBristol Heart Institute, Bristol Medical School, University of Bristol, Bristol BS8 1QU, UKBristol Heart Institute, Bristol Medical School, University of Bristol, Bristol BS8 1QU, UKUniversity Hospitals Bristol and Weston NHS Foundation Trust, Bristol BS1 3NU, UKBristol Heart Institute, Bristol Medical School, University of Bristol, Bristol BS8 1QU, UKBristol Heart Institute, Bristol Medical School, University of Bristol, Bristol BS8 1QU, UKBristol Heart Institute, Bristol Medical School, University of Bristol, Bristol BS8 1QU, UKCongenital heart defects (CHD) introduce haemodynamic changes; e.g., bicuspid aortic valve (BAV) presents a turbulent helical flow, which activates aortic pathological processes. Flow quantification is crucial for diagnostics and to plan corrective strategies. Multiple imaging modalities exist, with phase contrast magnetic resonance imaging (PC-MRI) being the current gold standard; however, multiple predetermined site measurements may be required, while 4D MRI allows for measurements of area (A) and velocity (U) in all spatial dimensions, acquiring a single volume and enabling a retrospective analysis at multiple locations. We assessed the feasibility of gathering hemodynamic insight into aortic hemodynamics by means of wave intensity analysis (WIA) derived from 4D MRI. Data were collected in <i>n</i> = 12 BAV patients and <i>n</i> = 7 healthy controls. Following data acquisition, WIA was successfully derived at three planes (ascending, thoracic and descending aorta) in all cases. The values of wave speed were physiological and, while the small sample limited any clinical interpretation of the results, the study shows the possibility of studying wave travel and wave reflection based on 4D MRI. Below, we demonstrate for the first time the feasibility of deriving wave intensity analysis from 4D flow data and open the door to research applications in different cardiovascular scenarios.https://www.mdpi.com/2306-5354/10/6/662aortabicuspid aortic valvemagnetic resonance imagingaortic valvewave intensity analysishemodynamics |
| spellingShingle | Froso Sophocleous Kiril Delchev Estefania De Garate Mark C. K. Hamilton Massimo Caputo Chiara Bucciarelli-Ducci Giovanni Biglino Feasibility of Wave Intensity Analysis from 4D Cardiovascular Magnetic Resonance Imaging Data Bioengineering aorta bicuspid aortic valve magnetic resonance imaging aortic valve wave intensity analysis hemodynamics |
| title | Feasibility of Wave Intensity Analysis from 4D Cardiovascular Magnetic Resonance Imaging Data |
| title_full | Feasibility of Wave Intensity Analysis from 4D Cardiovascular Magnetic Resonance Imaging Data |
| title_fullStr | Feasibility of Wave Intensity Analysis from 4D Cardiovascular Magnetic Resonance Imaging Data |
| title_full_unstemmed | Feasibility of Wave Intensity Analysis from 4D Cardiovascular Magnetic Resonance Imaging Data |
| title_short | Feasibility of Wave Intensity Analysis from 4D Cardiovascular Magnetic Resonance Imaging Data |
| title_sort | feasibility of wave intensity analysis from 4d cardiovascular magnetic resonance imaging data |
| topic | aorta bicuspid aortic valve magnetic resonance imaging aortic valve wave intensity analysis hemodynamics |
| url | https://www.mdpi.com/2306-5354/10/6/662 |
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