miRNA and lncRNA as potential tissue biomarkers in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is primary liver cancer, frequently diagnosed at advanced stages with limited therapeutic options. MicroRNAs (miRNAs) regulate target gene expression and through inhibitory competitive binding of miRNA influence cellular processes including carcinogenesis. Extensive ev...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-03-01
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| Series: | Non-coding RNA Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054023000719 |
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| author | Venkata Ramana Mallela Marie Rajtmajerová Andriy Trailin Václav Liška Kari Hemminki Filip Ambrozkiewicz |
| author_facet | Venkata Ramana Mallela Marie Rajtmajerová Andriy Trailin Václav Liška Kari Hemminki Filip Ambrozkiewicz |
| author_sort | Venkata Ramana Mallela |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is primary liver cancer, frequently diagnosed at advanced stages with limited therapeutic options. MicroRNAs (miRNAs) regulate target gene expression and through inhibitory competitive binding of miRNA influence cellular processes including carcinogenesis. Extensive evidence proved that certain miRNA's are specifically expressed in neoplastic tissues of HCC patients and are confirmed as important factors that can participate in the regulation of key signalling pathways in cancer cells. As such, miRNAs have a great potential in the clinical diagnosis and treatment of HCC and can improve the limitations of standard diagnosis and treatment. Long non-coding RNAs (lncRNAs) have a critical role in the development and progression of HCC. HCC-related lncRNAs have been demonstrated to exhibit abnormal expression and contribute to transformation process (such as proliferation, apoptosis, accelerated vascular formation, and gain of invasive potential) through their interaction with DNA, RNA, or proteins. LncRNAs can bind mRNAs to release their target mRNA and enable its translation. These lncRNA-miRNA networks regulate cancer cell expression and so its proliferation, apoptosis, invasion, metastasis, angiogenesis, epithelial-mesenchymal transition (EMT), drug resistance, and autophagy. In this narrative review, we focus on miRNA and lncRNA in HCC tumor tissue and their interaction as current tools, and biomarkers and therapeutic targets unravelled in recent years. |
| first_indexed | 2024-03-10T04:31:22Z |
| format | Article |
| id | doaj.art-ff2399a21c434b7b85e345ab1df5cb2f |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-25T01:13:12Z |
| publishDate | 2024-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-ff2399a21c434b7b85e345ab1df5cb2f2024-03-10T05:12:27ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402024-03-01912432miRNA and lncRNA as potential tissue biomarkers in hepatocellular carcinomaVenkata Ramana Mallela0Marie Rajtmajerová1Andriy Trailin2Václav Liška3Kari Hemminki4Filip Ambrozkiewicz5Laboratory of Translational Cancer Genomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, 323 00, Pilsen, Czech RepublicLaboratory of Translational Cancer Genomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, 323 00, Pilsen, Czech RepublicLaboratory of Translational Cancer Genomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, 323 00, Pilsen, Czech RepublicLaboratory of Cancer Treatment and Tissue Regeneration, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, 323 00, Pilsen, Czech Republic; Department of Surgery, University Hospital in Pilsen and Faculty of Medicine in Pilsen, Charles University, Alej Svobody 80, 323 00, Pilsen, Czech RepublicLaboratory of Translational Cancer Genomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, 323 00, Pilsen, Czech Republic; Department of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, GermanyLaboratory of Translational Cancer Genomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, 323 00, Pilsen, Czech Republic; Corresponding author.Hepatocellular carcinoma (HCC) is primary liver cancer, frequently diagnosed at advanced stages with limited therapeutic options. MicroRNAs (miRNAs) regulate target gene expression and through inhibitory competitive binding of miRNA influence cellular processes including carcinogenesis. Extensive evidence proved that certain miRNA's are specifically expressed in neoplastic tissues of HCC patients and are confirmed as important factors that can participate in the regulation of key signalling pathways in cancer cells. As such, miRNAs have a great potential in the clinical diagnosis and treatment of HCC and can improve the limitations of standard diagnosis and treatment. Long non-coding RNAs (lncRNAs) have a critical role in the development and progression of HCC. HCC-related lncRNAs have been demonstrated to exhibit abnormal expression and contribute to transformation process (such as proliferation, apoptosis, accelerated vascular formation, and gain of invasive potential) through their interaction with DNA, RNA, or proteins. LncRNAs can bind mRNAs to release their target mRNA and enable its translation. These lncRNA-miRNA networks regulate cancer cell expression and so its proliferation, apoptosis, invasion, metastasis, angiogenesis, epithelial-mesenchymal transition (EMT), drug resistance, and autophagy. In this narrative review, we focus on miRNA and lncRNA in HCC tumor tissue and their interaction as current tools, and biomarkers and therapeutic targets unravelled in recent years.http://www.sciencedirect.com/science/article/pii/S2468054023000719Hepatocellular carcinomaMessenger Ribonucleic acidMicro Ribonucleic acidLong noncoding Ribonucleic acidBiomarkersPrognostic |
| spellingShingle | Venkata Ramana Mallela Marie Rajtmajerová Andriy Trailin Václav Liška Kari Hemminki Filip Ambrozkiewicz miRNA and lncRNA as potential tissue biomarkers in hepatocellular carcinoma Non-coding RNA Research Hepatocellular carcinoma Messenger Ribonucleic acid Micro Ribonucleic acid Long noncoding Ribonucleic acid Biomarkers Prognostic |
| title | miRNA and lncRNA as potential tissue biomarkers in hepatocellular carcinoma |
| title_full | miRNA and lncRNA as potential tissue biomarkers in hepatocellular carcinoma |
| title_fullStr | miRNA and lncRNA as potential tissue biomarkers in hepatocellular carcinoma |
| title_full_unstemmed | miRNA and lncRNA as potential tissue biomarkers in hepatocellular carcinoma |
| title_short | miRNA and lncRNA as potential tissue biomarkers in hepatocellular carcinoma |
| title_sort | mirna and lncrna as potential tissue biomarkers in hepatocellular carcinoma |
| topic | Hepatocellular carcinoma Messenger Ribonucleic acid Micro Ribonucleic acid Long noncoding Ribonucleic acid Biomarkers Prognostic |
| url | http://www.sciencedirect.com/science/article/pii/S2468054023000719 |
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