Epigenetic Mechanisms of Escape from BRAF Oncogene Dependency
About eight percent of all human tumors (including 50% of melanomas) carry gain-of-function mutations in the BRAF oncogene. Mutated BRAF and subsequent hyperactivation of the MAPK signaling pathway has motivated the use of MAPK-targeted therapies for these tumors. Despite great promise, however, MAP...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-10-01
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Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/11/10/1480 |