The EDCMET Project: Metabolic Effects of Endocrine Disruptors
Endocrine disruptors (EDs) are defined as chemicals that mimic, block, or interfere with hormones in the body’s endocrine systems and have been associated with a diverse array of health issues. The concept of endocrine disruption has recently been extended to metabolic alterations that may result in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/8/3021 |
| _version_ | 1797569754018349056 |
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| author | Jenni Küblbeck Taina Vuorio Jonna Niskanen Vittorio Fortino Albert Braeuning Khaled Abass Arja Rautio Jukka Hakkola Paavo Honkakoski Anna-Liisa Levonen |
| author_facet | Jenni Küblbeck Taina Vuorio Jonna Niskanen Vittorio Fortino Albert Braeuning Khaled Abass Arja Rautio Jukka Hakkola Paavo Honkakoski Anna-Liisa Levonen |
| author_sort | Jenni Küblbeck |
| collection | DOAJ |
| description | Endocrine disruptors (EDs) are defined as chemicals that mimic, block, or interfere with hormones in the body’s endocrine systems and have been associated with a diverse array of health issues. The concept of endocrine disruption has recently been extended to metabolic alterations that may result in diseases, such as obesity, diabetes, and fatty liver disease, and constitute an increasing health concern worldwide. However, while epidemiological and experimental data on the close association of EDs and adverse metabolic effects are mounting, predictive methods and models to evaluate the detailed mechanisms and pathways behind these observed effects are lacking, thus restricting the regulatory risk assessment of EDs. The EDCMET (Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways) project brings together systems toxicologists; experimental biologists with a thorough understanding of the molecular mechanisms of metabolic disease and comprehensive in vitro and in vivo methodological skills; and, ultimately, epidemiologists linking environmental exposure to adverse metabolic outcomes. During its 5-year journey, EDCMET aims to identify novel ED mechanisms of action, to generate (pre)validated test methods to assess the metabolic effects of Eds, and to predict emergent adverse biological phenotypes by following the adverse outcome pathway (AOP) paradigm. |
| first_indexed | 2024-03-10T20:15:01Z |
| format | Article |
| id | doaj.art-ff26a03b74de4fce88dd9c25a9c96461 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:15:01Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ff26a03b74de4fce88dd9c25a9c964612023-11-19T22:38:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01218302110.3390/ijms21083021The EDCMET Project: Metabolic Effects of Endocrine DisruptorsJenni Küblbeck0Taina Vuorio1Jonna Niskanen2Vittorio Fortino3Albert Braeuning4Khaled Abass5Arja Rautio6Jukka Hakkola7Paavo Honkakoski8Anna-Liisa Levonen9A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70210 Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70210 Kuopio, FinlandSchool of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70210 Kuopio, FinlandInstitute of Biomedicine, University of Eastern Finland, P.O. Box 1627, FI-70210 Kuopio, FinlandDepartment Food Safety, German Federal Institute for Risk Assessment, DE-10589 Berlin, GermanyArctic Health, Faculty of Medicine, University of Oulu, P.O. Box 5000, FI-90014 Oulu, FinlandArctic Health, Faculty of Medicine, University of Oulu, P.O. Box 5000, FI-90014 Oulu, FinlandResearch Unit of Biomedicine, Pharmacology and Toxicology, University of Oulu, P.O. Box 5000, FI-90014 Oulu, FinlandSchool of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70210 Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70210 Kuopio, FinlandEndocrine disruptors (EDs) are defined as chemicals that mimic, block, or interfere with hormones in the body’s endocrine systems and have been associated with a diverse array of health issues. The concept of endocrine disruption has recently been extended to metabolic alterations that may result in diseases, such as obesity, diabetes, and fatty liver disease, and constitute an increasing health concern worldwide. However, while epidemiological and experimental data on the close association of EDs and adverse metabolic effects are mounting, predictive methods and models to evaluate the detailed mechanisms and pathways behind these observed effects are lacking, thus restricting the regulatory risk assessment of EDs. The EDCMET (Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways) project brings together systems toxicologists; experimental biologists with a thorough understanding of the molecular mechanisms of metabolic disease and comprehensive in vitro and in vivo methodological skills; and, ultimately, epidemiologists linking environmental exposure to adverse metabolic outcomes. During its 5-year journey, EDCMET aims to identify novel ED mechanisms of action, to generate (pre)validated test methods to assess the metabolic effects of Eds, and to predict emergent adverse biological phenotypes by following the adverse outcome pathway (AOP) paradigm.https://www.mdpi.com/1422-0067/21/8/3021endocrine disruptors (EDs)nuclear receptors (NRs)metabolismmetabolic syndromeobesityrisk assessment |
| spellingShingle | Jenni Küblbeck Taina Vuorio Jonna Niskanen Vittorio Fortino Albert Braeuning Khaled Abass Arja Rautio Jukka Hakkola Paavo Honkakoski Anna-Liisa Levonen The EDCMET Project: Metabolic Effects of Endocrine Disruptors International Journal of Molecular Sciences endocrine disruptors (EDs) nuclear receptors (NRs) metabolism metabolic syndrome obesity risk assessment |
| title | The EDCMET Project: Metabolic Effects of Endocrine Disruptors |
| title_full | The EDCMET Project: Metabolic Effects of Endocrine Disruptors |
| title_fullStr | The EDCMET Project: Metabolic Effects of Endocrine Disruptors |
| title_full_unstemmed | The EDCMET Project: Metabolic Effects of Endocrine Disruptors |
| title_short | The EDCMET Project: Metabolic Effects of Endocrine Disruptors |
| title_sort | edcmet project metabolic effects of endocrine disruptors |
| topic | endocrine disruptors (EDs) nuclear receptors (NRs) metabolism metabolic syndrome obesity risk assessment |
| url | https://www.mdpi.com/1422-0067/21/8/3021 |
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