Opioid Use Disorder Induces Oxidative Stress and Inflammation: The Attenuating Effect of Methadone Maintenance Treatment
Objective: Frequent use of opioids produces reactive oxygen species, upregulates inflammatory factors, and contributes to opiate dependence. In this study, we examined perturbations of plasma oxidative and inflammatory markers in patients with opioid use disorder in two phases. In the first phase, w...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2018-02-01
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| Series: | Iranian Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://ijps.tums.ac.ir/index.php/ijps/article/view/1084 |
| _version_ | 1818049537473773568 |
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| author | Ali Salarian Mehri Kadkhodaee Maryam Zahmatkesh Behjat Sefi Enayatollah Bakhshi Shahin Akhondzadeh Soheila Adeli Hassan Askari Mohammad Arbabi |
| author_facet | Ali Salarian Mehri Kadkhodaee Maryam Zahmatkesh Behjat Sefi Enayatollah Bakhshi Shahin Akhondzadeh Soheila Adeli Hassan Askari Mohammad Arbabi |
| author_sort | Ali Salarian |
| collection | DOAJ |
| description | Objective: Frequent use of opioids produces reactive oxygen species, upregulates inflammatory factors, and contributes to opiate dependence. In this study, we examined perturbations of plasma oxidative and inflammatory markers in patients with opioid use disorder in two phases. In the first phase, we compared the oxidative status in patients with opioid use disorders and in healthy controls; and in the second phase, we examined oxidative changes before and after methadone maintenance treatment.
Method: To explore whether oxidative changes were associated with opioid use disorder, we compared plasma oxidative and inflammatory markers in patients with opioid use disorder and in smoking and non-smoking healthy participants. All participants completed measures of catalase (CAT), glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), matrix metalloproteinase (MMP-9), and TNF-α at baseline. Baseline measures were compared using Kruskal-Wallis test. In the second phase, to explore oxidative changes during transition from opium use to methadone, blood and urine samples of patients with opioid use disorder were re-evaluated on Days 3, 7, and 14 after methadone therapy. Repeated measures analysis was used to determine the relative contribution of intervention to changes in CAT, GSH, MDA, SOD, MMP-9, and TNF-α level over time.
Results: We observed lower SOD and catalase activities, and higher TNF-α and MMP-9 level in patients compared to the two comparison groups. Opioids exacerbated the oxidative imbalance and superimposed the underlying oxidative injury in smoker comparison group. Methadone therapy was associated with lower MMP-9 and TNF-α level, and higher SOD and catalase activities two weeks after therapy; showing an improvement in oxidative profile.
Conclusion: This was an investigation indicating an oxidative imbalance before methadone therapy and during early days of transition from opium use to methadone. Being aware of redox status is crucial for determining an appropriate antioxidant therapy in opioid use disorder. |
| first_indexed | 2024-12-10T10:39:09Z |
| format | Article |
| id | doaj.art-ff27ac1b0082474898c99945b7082869 |
| institution | Directory Open Access Journal |
| issn | 1735-4587 2008-2215 |
| language | English |
| last_indexed | 2024-12-10T10:39:09Z |
| publishDate | 2018-02-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Psychiatry |
| spelling | doaj.art-ff27ac1b0082474898c99945b70828692022-12-22T01:52:22ZengTehran University of Medical SciencesIranian Journal of Psychiatry1735-45872008-22152018-02-01131616Opioid Use Disorder Induces Oxidative Stress and Inflammation: The Attenuating Effect of Methadone Maintenance TreatmentAli Salarian0Mehri Kadkhodaee1Maryam Zahmatkesh2Behjat Sefi3Enayatollah Bakhshi4Shahin Akhondzadeh5Soheila Adeli6Hassan Askari7Mohammad Arbabi8Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.. Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. Research Center of Behavioral and Cognitive Sciences, Tehran University of Medical Sciences, Tehran, Iran.Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, IranDepartment of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Iran.Objective: Frequent use of opioids produces reactive oxygen species, upregulates inflammatory factors, and contributes to opiate dependence. In this study, we examined perturbations of plasma oxidative and inflammatory markers in patients with opioid use disorder in two phases. In the first phase, we compared the oxidative status in patients with opioid use disorders and in healthy controls; and in the second phase, we examined oxidative changes before and after methadone maintenance treatment. Method: To explore whether oxidative changes were associated with opioid use disorder, we compared plasma oxidative and inflammatory markers in patients with opioid use disorder and in smoking and non-smoking healthy participants. All participants completed measures of catalase (CAT), glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), matrix metalloproteinase (MMP-9), and TNF-α at baseline. Baseline measures were compared using Kruskal-Wallis test. In the second phase, to explore oxidative changes during transition from opium use to methadone, blood and urine samples of patients with opioid use disorder were re-evaluated on Days 3, 7, and 14 after methadone therapy. Repeated measures analysis was used to determine the relative contribution of intervention to changes in CAT, GSH, MDA, SOD, MMP-9, and TNF-α level over time. Results: We observed lower SOD and catalase activities, and higher TNF-α and MMP-9 level in patients compared to the two comparison groups. Opioids exacerbated the oxidative imbalance and superimposed the underlying oxidative injury in smoker comparison group. Methadone therapy was associated with lower MMP-9 and TNF-α level, and higher SOD and catalase activities two weeks after therapy; showing an improvement in oxidative profile. Conclusion: This was an investigation indicating an oxidative imbalance before methadone therapy and during early days of transition from opium use to methadone. Being aware of redox status is crucial for determining an appropriate antioxidant therapy in opioid use disorder.https://ijps.tums.ac.ir/index.php/ijps/article/view/1084Oxidative statusOpioid-use disorderMethadone maintenance treatment |
| spellingShingle | Ali Salarian Mehri Kadkhodaee Maryam Zahmatkesh Behjat Sefi Enayatollah Bakhshi Shahin Akhondzadeh Soheila Adeli Hassan Askari Mohammad Arbabi Opioid Use Disorder Induces Oxidative Stress and Inflammation: The Attenuating Effect of Methadone Maintenance Treatment Iranian Journal of Psychiatry Oxidative status Opioid-use disorder Methadone maintenance treatment |
| title | Opioid Use Disorder Induces Oxidative Stress and Inflammation: The Attenuating Effect of Methadone Maintenance Treatment |
| title_full | Opioid Use Disorder Induces Oxidative Stress and Inflammation: The Attenuating Effect of Methadone Maintenance Treatment |
| title_fullStr | Opioid Use Disorder Induces Oxidative Stress and Inflammation: The Attenuating Effect of Methadone Maintenance Treatment |
| title_full_unstemmed | Opioid Use Disorder Induces Oxidative Stress and Inflammation: The Attenuating Effect of Methadone Maintenance Treatment |
| title_short | Opioid Use Disorder Induces Oxidative Stress and Inflammation: The Attenuating Effect of Methadone Maintenance Treatment |
| title_sort | opioid use disorder induces oxidative stress and inflammation the attenuating effect of methadone maintenance treatment |
| topic | Oxidative status Opioid-use disorder Methadone maintenance treatment |
| url | https://ijps.tums.ac.ir/index.php/ijps/article/view/1084 |
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