Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents
As resistance to clinically available antibiotics persistently increases, applying new strategies to target pathogenic bacteria are paramount to design effective drugs. Bacterial proteases play vital roles in cell viability and stress response, contributing to the pathogenicity of the resistant bac...
| Main Authors: | , |
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2022-05-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://chimia.ch/chimia/article/view/6025 |
| _version_ | 1811328503115677696 |
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| author | Cansu Kaya Anna K. H. Hirsch |
| author_facet | Cansu Kaya Anna K. H. Hirsch |
| author_sort | Cansu Kaya |
| collection | DOAJ |
| description |
As resistance to clinically available antibiotics persistently increases, applying new strategies to target pathogenic bacteria are paramount to design effective drugs. Bacterial proteases play vital roles in cell viability and stress response, contributing to the pathogenicity of the resistant bacteria. Targeting these extracellular enzymes by antivirulence therapy is a prominent strategy in combating multi-drug resistant bacteria. By preventing the colonization and infiltration of the host, this method can lower selection pressure and reduce resistance development significantly. Here, we review the role of bacterial proteases, the rise of antivirulence therapy and we report on the development of novel antivirulence agents targeting two key virulence factors: elastase B (LasB) from Pseudomonas aeruginosa and collagenase H (ColH) from Clostridium histolyticum.
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| first_indexed | 2024-04-13T15:26:15Z |
| format | Article |
| id | doaj.art-ff29f4b3e9e94326a82434bf323ce548 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-04-13T15:26:15Z |
| publishDate | 2022-05-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-ff29f4b3e9e94326a82434bf323ce5482022-12-22T02:41:30ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242022-05-0176510.2533/chimia.2022.402Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence AgentsCansu Kaya0Anna K. H. Hirsch1Helmholtz Institute for Pharmaceutical Research, University of Saarland, Campus E8.1, 66123, Saarbrücken, GermanyHelmholtz Institute for Pharmaceutical Research, University of Saarland, Campus E8.1, 66123, Saarbrücken, Germany As resistance to clinically available antibiotics persistently increases, applying new strategies to target pathogenic bacteria are paramount to design effective drugs. Bacterial proteases play vital roles in cell viability and stress response, contributing to the pathogenicity of the resistant bacteria. Targeting these extracellular enzymes by antivirulence therapy is a prominent strategy in combating multi-drug resistant bacteria. By preventing the colonization and infiltration of the host, this method can lower selection pressure and reduce resistance development significantly. Here, we review the role of bacterial proteases, the rise of antivirulence therapy and we report on the development of novel antivirulence agents targeting two key virulence factors: elastase B (LasB) from Pseudomonas aeruginosa and collagenase H (ColH) from Clostridium histolyticum. https://chimia.ch/chimia/article/view/6025Anti-virulence therapyCollagenaseElastaseProteases |
| spellingShingle | Cansu Kaya Anna K. H. Hirsch Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents CHIMIA Anti-virulence therapy Collagenase Elastase Proteases |
| title | Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents |
| title_full | Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents |
| title_fullStr | Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents |
| title_full_unstemmed | Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents |
| title_short | Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents |
| title_sort | targeting extracellular bacterial proteases for the development of novel antivirulence agents |
| topic | Anti-virulence therapy Collagenase Elastase Proteases |
| url | https://chimia.ch/chimia/article/view/6025 |
| work_keys_str_mv | AT cansukaya targetingextracellularbacterialproteasesforthedevelopmentofnovelantivirulenceagents AT annakhhirsch targetingextracellularbacterialproteasesforthedevelopmentofnovelantivirulenceagents |