Therapeutic potential of natural compounds for treatment of chronic obstructive pulmonary disease: Current status and future perspective
Chronic obstructive pulmonary disease (COPD) is a lung disease which is the third most common cause of premature death globally. Inhaling dangerous gases, cigarette smoking, and exposure to pollution are the main factors contributing to the development of COPD. These factors may harm lung tissue and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-08-01
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| Series: | European Journal of Medicinal Chemistry Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772417424000311 |
| _version_ | 1797198827278565376 |
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| author | Sanjeev Kumar Sahu MD Musarraf Rain Manish Vyas |
| author_facet | Sanjeev Kumar Sahu MD Musarraf Rain Manish Vyas |
| author_sort | Sanjeev Kumar Sahu |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is a lung disease which is the third most common cause of premature death globally. Inhaling dangerous gases, cigarette smoking, and exposure to pollution are the main factors contributing to the development of COPD. These factors may harm lung tissue and create COPD causes. Increased synthesis of inflammatory mediators and proteases because of cigarette smoking exposure to transcriptional factors. Dysfunction of mitochondria essential part to lead and development of several human illnesses, such as chronic obstructive pulmonary disease. Alpha-1 antitrypsin deficiency boosts neutrophil elastase activity, which promotes tissue deterioration and emphysema (particularly in smokers because cigarette smoke also boosts protease activity). In this review, we discussed all these factors and summarized the conventional drug currently present for the treatment of COPD. In addition, we also focused on various natural compounds categorized under the flavonoids, polyphenols, alkaloids, glycosides and marine compounds which were reported for the effective treatment of COPD. |
| first_indexed | 2024-04-24T07:06:03Z |
| format | Article |
| id | doaj.art-ff2a8cc635904f94a839cf29f3e8989e |
| institution | Directory Open Access Journal |
| issn | 2772-4174 |
| language | English |
| last_indexed | 2024-04-24T07:06:03Z |
| publishDate | 2024-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Medicinal Chemistry Reports |
| spelling | doaj.art-ff2a8cc635904f94a839cf29f3e8989e2024-04-22T04:12:00ZengElsevierEuropean Journal of Medicinal Chemistry Reports2772-41742024-08-0111100159Therapeutic potential of natural compounds for treatment of chronic obstructive pulmonary disease: Current status and future perspectiveSanjeev Kumar Sahu0MD Musarraf Rain1Manish Vyas2Corresponding author. Tel.: +91 9993406614.; School of Pharmaceutical Sciences, Lovely Professional University, Punjab, 144411, IndiaSchool of Pharmaceutical Sciences, Lovely Professional University, Punjab, 144411, IndiaSchool of Pharmaceutical Sciences, Lovely Professional University, Punjab, 144411, IndiaChronic obstructive pulmonary disease (COPD) is a lung disease which is the third most common cause of premature death globally. Inhaling dangerous gases, cigarette smoking, and exposure to pollution are the main factors contributing to the development of COPD. These factors may harm lung tissue and create COPD causes. Increased synthesis of inflammatory mediators and proteases because of cigarette smoking exposure to transcriptional factors. Dysfunction of mitochondria essential part to lead and development of several human illnesses, such as chronic obstructive pulmonary disease. Alpha-1 antitrypsin deficiency boosts neutrophil elastase activity, which promotes tissue deterioration and emphysema (particularly in smokers because cigarette smoke also boosts protease activity). In this review, we discussed all these factors and summarized the conventional drug currently present for the treatment of COPD. In addition, we also focused on various natural compounds categorized under the flavonoids, polyphenols, alkaloids, glycosides and marine compounds which were reported for the effective treatment of COPD.http://www.sciencedirect.com/science/article/pii/S2772417424000311Chronic obstructive pulmonary diseaseOxidative stressReactive oxygen speciesGenetic factorsAlpha-1 antitrypsin deficiencyMitochondria dysfunction |
| spellingShingle | Sanjeev Kumar Sahu MD Musarraf Rain Manish Vyas Therapeutic potential of natural compounds for treatment of chronic obstructive pulmonary disease: Current status and future perspective European Journal of Medicinal Chemistry Reports Chronic obstructive pulmonary disease Oxidative stress Reactive oxygen species Genetic factors Alpha-1 antitrypsin deficiency Mitochondria dysfunction |
| title | Therapeutic potential of natural compounds for treatment of chronic obstructive pulmonary disease: Current status and future perspective |
| title_full | Therapeutic potential of natural compounds for treatment of chronic obstructive pulmonary disease: Current status and future perspective |
| title_fullStr | Therapeutic potential of natural compounds for treatment of chronic obstructive pulmonary disease: Current status and future perspective |
| title_full_unstemmed | Therapeutic potential of natural compounds for treatment of chronic obstructive pulmonary disease: Current status and future perspective |
| title_short | Therapeutic potential of natural compounds for treatment of chronic obstructive pulmonary disease: Current status and future perspective |
| title_sort | therapeutic potential of natural compounds for treatment of chronic obstructive pulmonary disease current status and future perspective |
| topic | Chronic obstructive pulmonary disease Oxidative stress Reactive oxygen species Genetic factors Alpha-1 antitrypsin deficiency Mitochondria dysfunction |
| url | http://www.sciencedirect.com/science/article/pii/S2772417424000311 |
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