Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns
Adverse birth outcomes present risk factors resulting in neonatal morbidity and mortality. Sufficient maternal hormonal concentrations are crucial for normal foetal development. Previous studies have shown a relationship between phthalate exposure and maternal hormonal levels during pregnancy. This...
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MDPI AG
2022-03-01
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| Online Access: | https://www.mdpi.com/2227-9067/9/3/413 |
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| author | Henrieta Hlisníková Branislav Kolena Miroslava Šidlovská Miloš Mlynček Ida Petrovičová |
| author_facet | Henrieta Hlisníková Branislav Kolena Miroslava Šidlovská Miloš Mlynček Ida Petrovičová |
| author_sort | Henrieta Hlisníková |
| collection | DOAJ |
| description | Adverse birth outcomes present risk factors resulting in neonatal morbidity and mortality. Sufficient maternal hormonal concentrations are crucial for normal foetal development. Previous studies have shown a relationship between phthalate exposure and maternal hormonal levels during pregnancy. This study aims to investigate if neonatal anthropometric parameters are associated with maternal endocrine parameters during the ≤15th week of gestation and the third trimester of pregnancy concerning phthalate exposure in pregnant women from Nitra, Slovakia. We used high-performance liquid chromatography, tandem mass spectrometry (HPLC-MS/MS), and electro-chemiluminescence immunoassay to quantify urinary concentrations of phthalates and serum concentrations of hormones and sex hormone-binding globulin (SHBG), respectively. We observed a mostly positive correlation between neonatal anthropometric parameters (gestational age, birth length, birth weight, head circumference) and maternal concentration of phthalate metabolites (<i>p</i> ≤ 0.05). The hierarchical multivariate regression results showed a statistically significant association between Apgar score at 5 min after delivery, gestational age, birth weight, head circumference, and maternal endocrine parameters during pregnancy (<i>p</i> ≤ 0.05), adjusted to phthalate metabolites. To the best of our knowledge, our study is the first to indicate that prenatal exposure to phthalates may also affect birth outcomes through interaction with the maternal endocrine system. |
| first_indexed | 2024-03-09T20:00:31Z |
| format | Article |
| id | doaj.art-ff2c9ec5e7d64099969591d20f98337b |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T20:00:31Z |
| publishDate | 2022-03-01 |
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| spelling | doaj.art-ff2c9ec5e7d64099969591d20f98337b2023-11-24T00:47:44ZengMDPI AGChildren2227-90672022-03-019341310.3390/children9030413Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of NewbornsHenrieta Hlisníková0Branislav Kolena1Miroslava Šidlovská2Miloš Mlynček3Ida Petrovičová4Department of Zoology and Anthropology, Faculty of Natural Sciences and Informatics, Constantine the Philosopher University in Nitra, 94974 Nitra, SlovakiaDepartment of Zoology and Anthropology, Faculty of Natural Sciences and Informatics, Constantine the Philosopher University in Nitra, 94974 Nitra, SlovakiaDepartment of Zoology and Anthropology, Faculty of Natural Sciences and Informatics, Constantine the Philosopher University in Nitra, 94974 Nitra, SlovakiaDepartment of Nursing, Faculty of Social Sciences and Health Care, Constantine the Philosopher University in Nitra, 94974 Nitra, SlovakiaDepartment of Zoology and Anthropology, Faculty of Natural Sciences and Informatics, Constantine the Philosopher University in Nitra, 94974 Nitra, SlovakiaAdverse birth outcomes present risk factors resulting in neonatal morbidity and mortality. Sufficient maternal hormonal concentrations are crucial for normal foetal development. Previous studies have shown a relationship between phthalate exposure and maternal hormonal levels during pregnancy. This study aims to investigate if neonatal anthropometric parameters are associated with maternal endocrine parameters during the ≤15th week of gestation and the third trimester of pregnancy concerning phthalate exposure in pregnant women from Nitra, Slovakia. We used high-performance liquid chromatography, tandem mass spectrometry (HPLC-MS/MS), and electro-chemiluminescence immunoassay to quantify urinary concentrations of phthalates and serum concentrations of hormones and sex hormone-binding globulin (SHBG), respectively. We observed a mostly positive correlation between neonatal anthropometric parameters (gestational age, birth length, birth weight, head circumference) and maternal concentration of phthalate metabolites (<i>p</i> ≤ 0.05). The hierarchical multivariate regression results showed a statistically significant association between Apgar score at 5 min after delivery, gestational age, birth weight, head circumference, and maternal endocrine parameters during pregnancy (<i>p</i> ≤ 0.05), adjusted to phthalate metabolites. To the best of our knowledge, our study is the first to indicate that prenatal exposure to phthalates may also affect birth outcomes through interaction with the maternal endocrine system.https://www.mdpi.com/2227-9067/9/3/413phthalate metabolitesmaternal hormonesprenatal exposurenewbornsbirth outcomesanthropometry |
| spellingShingle | Henrieta Hlisníková Branislav Kolena Miroslava Šidlovská Miloš Mlynček Ida Petrovičová Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns Children phthalate metabolites maternal hormones prenatal exposure newborns birth outcomes anthropometry |
| title | Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns |
| title_full | Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns |
| title_fullStr | Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns |
| title_full_unstemmed | Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns |
| title_short | Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns |
| title_sort | urinary phthalate biomarkers during pregnancy and maternal endocrine parameters in association with anthropometric parameters of newborns |
| topic | phthalate metabolites maternal hormones prenatal exposure newborns birth outcomes anthropometry |
| url | https://www.mdpi.com/2227-9067/9/3/413 |
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