Baseline grey matter volumes and white matter hyperintensities predict decline in functional activities in older adults over a 5-year follow-up period
Introduction: Functional independence is an essential predictor of quality of life in aging, yet few accessible predictors of functional decline have been identified. This study examined associations between baseline structural neuroimaging markers and longitudinal functional status. Methods: Linear...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158223000827 |
| _version_ | 1827925851616837632 |
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| author | Corey J. Bolton Omair A. Khan Elizabeth E. Moore Kimberly R. Pechman L. Taylor Davis Dandan Liu Bennett A. Landman Katherine A. Gifford Timothy J. Hohman Angela L. Jefferson |
| author_facet | Corey J. Bolton Omair A. Khan Elizabeth E. Moore Kimberly R. Pechman L. Taylor Davis Dandan Liu Bennett A. Landman Katherine A. Gifford Timothy J. Hohman Angela L. Jefferson |
| author_sort | Corey J. Bolton |
| collection | DOAJ |
| description | Introduction: Functional independence is an essential predictor of quality of life in aging, yet few accessible predictors of functional decline have been identified. This study examined associations between baseline structural neuroimaging markers and longitudinal functional status. Methods: Linear mixed effects models with follow-up time interaction terms related baseline grey matter volume and white matter hyperintensities (WMHs) to functional trajectory, adjusting for demographic and medical covariates. Subsequent models assessed interactions with cognitive status and apolipoprotein E (APOE) ε4 status. Results: Smaller baseline grey matter volumes, particularly in regions commonly affected by Alzheimer’s disease (AD), and greater baseline WMHs were associated with faster functional decline over a mean 5-year follow-up. Effects were stronger in APOE-ε4 carriers on grey matter variables. Cognitive status interacted with most MRI variables. Discussion: Greater atrophy in AD-related regions and higher WMH burden at study entry were associated with faster functional decline, particularly among participants at increased risk of AD. |
| first_indexed | 2024-03-13T05:29:01Z |
| format | Article |
| id | doaj.art-ff2d236c6b894e25ab7ee1af6a34ea48 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-03-13T05:29:01Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-ff2d236c6b894e25ab7ee1af6a34ea482023-06-15T04:55:49ZengElsevierNeuroImage: Clinical2213-15822023-01-0138103393Baseline grey matter volumes and white matter hyperintensities predict decline in functional activities in older adults over a 5-year follow-up periodCorey J. Bolton0Omair A. Khan1Elizabeth E. Moore2Kimberly R. Pechman3L. Taylor Davis4Dandan Liu5Bennett A. Landman6Katherine A. Gifford7Timothy J. Hohman8Angela L. Jefferson9Vanderbilt Memory and Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USAVanderbilt Memory and Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USAVanderbilt Memory and Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, TN, USAVanderbilt Memory and Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USAVanderbilt Memory and Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USAVanderbilt Memory and Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USAVanderbilt Memory and Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USAVanderbilt Memory and Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USAVanderbilt Memory and Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USAVanderbilt Memory and Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Corresponding author at: Vanderbilt Memory and Alzheimer’s Center, 1207 17th Avenue South, Suite 204, Nashville, TN 37212.Introduction: Functional independence is an essential predictor of quality of life in aging, yet few accessible predictors of functional decline have been identified. This study examined associations between baseline structural neuroimaging markers and longitudinal functional status. Methods: Linear mixed effects models with follow-up time interaction terms related baseline grey matter volume and white matter hyperintensities (WMHs) to functional trajectory, adjusting for demographic and medical covariates. Subsequent models assessed interactions with cognitive status and apolipoprotein E (APOE) ε4 status. Results: Smaller baseline grey matter volumes, particularly in regions commonly affected by Alzheimer’s disease (AD), and greater baseline WMHs were associated with faster functional decline over a mean 5-year follow-up. Effects were stronger in APOE-ε4 carriers on grey matter variables. Cognitive status interacted with most MRI variables. Discussion: Greater atrophy in AD-related regions and higher WMH burden at study entry were associated with faster functional decline, particularly among participants at increased risk of AD.http://www.sciencedirect.com/science/article/pii/S2213158223000827Alzheimer’s diseaseNeuroimagingBrain MRIFunctional declineActivities of daily livingWhite matter hyperintensities |
| spellingShingle | Corey J. Bolton Omair A. Khan Elizabeth E. Moore Kimberly R. Pechman L. Taylor Davis Dandan Liu Bennett A. Landman Katherine A. Gifford Timothy J. Hohman Angela L. Jefferson Baseline grey matter volumes and white matter hyperintensities predict decline in functional activities in older adults over a 5-year follow-up period NeuroImage: Clinical Alzheimer’s disease Neuroimaging Brain MRI Functional decline Activities of daily living White matter hyperintensities |
| title | Baseline grey matter volumes and white matter hyperintensities predict decline in functional activities in older adults over a 5-year follow-up period |
| title_full | Baseline grey matter volumes and white matter hyperintensities predict decline in functional activities in older adults over a 5-year follow-up period |
| title_fullStr | Baseline grey matter volumes and white matter hyperintensities predict decline in functional activities in older adults over a 5-year follow-up period |
| title_full_unstemmed | Baseline grey matter volumes and white matter hyperintensities predict decline in functional activities in older adults over a 5-year follow-up period |
| title_short | Baseline grey matter volumes and white matter hyperintensities predict decline in functional activities in older adults over a 5-year follow-up period |
| title_sort | baseline grey matter volumes and white matter hyperintensities predict decline in functional activities in older adults over a 5 year follow up period |
| topic | Alzheimer’s disease Neuroimaging Brain MRI Functional decline Activities of daily living White matter hyperintensities |
| url | http://www.sciencedirect.com/science/article/pii/S2213158223000827 |
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