The functional connectivity of basal forebrain is associated with superior memory performance in older adults: a case-control study
Abstract Background Aging is related with memory deterioration. However, some older adults demonstrate superior performance compared to age- and education-matched adults, who are referred to as superagers. To explore the neural mechanisms that mediate their unusually successful memory is important n...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-022-03226-w |
| _version_ | 1811334662858997760 |
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| author | Shu-hong Jia Zhi Zhou Wen Shao Xiao Zhou Shuang Lv Wen Hong Dan-tao Peng |
| author_facet | Shu-hong Jia Zhi Zhou Wen Shao Xiao Zhou Shuang Lv Wen Hong Dan-tao Peng |
| author_sort | Shu-hong Jia |
| collection | DOAJ |
| description | Abstract Background Aging is related with memory deterioration. However, some older adults demonstrate superior performance compared to age- and education-matched adults, who are referred to as superagers. To explore the neural mechanisms that mediate their unusually successful memory is important not only for the ameliorate the effects of aging in brain, but also for the prevention of neurodegenerative diseases, including Alzheimer’s disease. This case-control study is aimed to investigate the effects of volume and function of basal forebrain cholinergic neurons on the cognition of superagers. Methods The morphometric and resting-state functional MRI analysis, including 34 superagers and 48 typical older adults, were conducted. We compared the basal forebrain gray matter density and related resting-state functional connectivity (FC) in the two groups. To investigate the relationship of FC with cognition, we measure the correlation of significant altered FC and individual cognitive domain. Results No significant differences of gray matter density was observed between superagers and typical older adults. The superagers had stronger cortical FC of Ch1-3 with left putamen and insular cortex. The strength of FC positively correlated with global cognition, memory and executive function. Conclusions These findings demonstrated that the stronger FC of basal forebrain correlated with specific cognitive difference in global cognition and domains of memory and executive function in superagers. |
| first_indexed | 2024-04-13T17:11:25Z |
| format | Article |
| id | doaj.art-ff2d2c15a1f9446b83ea6fb87c3d9c09 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-04-13T17:11:25Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-ff2d2c15a1f9446b83ea6fb87c3d9c092022-12-22T02:38:16ZengBMCBMC Geriatrics1471-23182022-06-012211910.1186/s12877-022-03226-wThe functional connectivity of basal forebrain is associated with superior memory performance in older adults: a case-control studyShu-hong Jia0Zhi Zhou1Wen Shao2Xiao Zhou3Shuang Lv4Wen Hong5Dan-tao Peng6Department of Neurology, China-Japan Friendship HospitalDepartment of Neurology, China-Japan Friendship HospitalDepartment of Neurology, China-Japan Friendship HospitalDepartment of Neurology, China-Japan Friendship HospitalDepartment of Neurology, China-Japan Friendship HospitalDepartment of Radiology, China-Japan Friendship HospitalDepartment of Neurology, China-Japan Friendship HospitalAbstract Background Aging is related with memory deterioration. However, some older adults demonstrate superior performance compared to age- and education-matched adults, who are referred to as superagers. To explore the neural mechanisms that mediate their unusually successful memory is important not only for the ameliorate the effects of aging in brain, but also for the prevention of neurodegenerative diseases, including Alzheimer’s disease. This case-control study is aimed to investigate the effects of volume and function of basal forebrain cholinergic neurons on the cognition of superagers. Methods The morphometric and resting-state functional MRI analysis, including 34 superagers and 48 typical older adults, were conducted. We compared the basal forebrain gray matter density and related resting-state functional connectivity (FC) in the two groups. To investigate the relationship of FC with cognition, we measure the correlation of significant altered FC and individual cognitive domain. Results No significant differences of gray matter density was observed between superagers and typical older adults. The superagers had stronger cortical FC of Ch1-3 with left putamen and insular cortex. The strength of FC positively correlated with global cognition, memory and executive function. Conclusions These findings demonstrated that the stronger FC of basal forebrain correlated with specific cognitive difference in global cognition and domains of memory and executive function in superagers.https://doi.org/10.1186/s12877-022-03226-wSuperagersMemoryBasal forebrainResting-state functional MRIFunctional connectivity |
| spellingShingle | Shu-hong Jia Zhi Zhou Wen Shao Xiao Zhou Shuang Lv Wen Hong Dan-tao Peng The functional connectivity of basal forebrain is associated with superior memory performance in older adults: a case-control study BMC Geriatrics Superagers Memory Basal forebrain Resting-state functional MRI Functional connectivity |
| title | The functional connectivity of basal forebrain is associated with superior memory performance in older adults: a case-control study |
| title_full | The functional connectivity of basal forebrain is associated with superior memory performance in older adults: a case-control study |
| title_fullStr | The functional connectivity of basal forebrain is associated with superior memory performance in older adults: a case-control study |
| title_full_unstemmed | The functional connectivity of basal forebrain is associated with superior memory performance in older adults: a case-control study |
| title_short | The functional connectivity of basal forebrain is associated with superior memory performance in older adults: a case-control study |
| title_sort | functional connectivity of basal forebrain is associated with superior memory performance in older adults a case control study |
| topic | Superagers Memory Basal forebrain Resting-state functional MRI Functional connectivity |
| url | https://doi.org/10.1186/s12877-022-03226-w |
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