Subthalamic oscillatory activity and connectivity during gait in Parkinson's disease
Local field potentials (LFP) of the subthalamic nucleus (STN) recorded during walking may provide clues for determining the function of the STN during gait and also, may be used as biomarker to steer adaptive brain stimulation devices. Here, we present LFP recordings from an implanted sensing neuros...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158218301475 |
| _version_ | 1818278022733627392 |
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| author | Franz Hell Annika Plate Jan H. Mehrkens Kai Bötzel |
| author_facet | Franz Hell Annika Plate Jan H. Mehrkens Kai Bötzel |
| author_sort | Franz Hell |
| collection | DOAJ |
| description | Local field potentials (LFP) of the subthalamic nucleus (STN) recorded during walking may provide clues for determining the function of the STN during gait and also, may be used as biomarker to steer adaptive brain stimulation devices. Here, we present LFP recordings from an implanted sensing neurostimulator (Medtronic Activa PC + S) during walking and rest with and without stimulation in 10 patients with Parkinson's disease and electrodes placed bilaterally in the STN. We also present recordings from two of these patients recorded with externalized leads. We analyzed changes in overall frequency power, bilateral connectivity, high beta frequency oscillatory characteristics and gait-cycle related oscillatory activity. We report that deep brain stimulation improves gait parameters. High beta frequency power (20-30 Hz) and bilateral oscillatory connectivity are reduced during gait, while the attenuation of high beta power is absent during stimulation. Oscillatory characteristics are affected in a similar way. We describe a reduction in overall high beta burst amplitude and burst lifetimes during gait as compared to rest off stimulation. Investigating gait cycle related oscillatory dynamics, we found that alpha, beta and gamma frequency power is modulated in time during gait, locked to the gait cycle. We argue that these changes are related to movement induced artifacts and that these issues have important implications for similar research. Keywords: Deep brain stimulation, Subthalamic nucleus, Gait, Oscillations, Beta rhythm |
| first_indexed | 2024-12-12T23:10:50Z |
| format | Article |
| id | doaj.art-ff2e124ae5ea4e9a853cc8366715624d |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-12T23:10:50Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-ff2e124ae5ea4e9a853cc8366715624d2022-12-22T00:08:35ZengElsevierNeuroImage: Clinical2213-15822018-01-0119396405Subthalamic oscillatory activity and connectivity during gait in Parkinson's diseaseFranz Hell0Annika Plate1Jan H. Mehrkens2Kai Bötzel3Department of Neurology, Ludwig-Maximilians-Universität München, Marchioninistr. 15, D-81377 Munich, Germany; Graduate School of Systemic Neurosciences, GSN, Ludwig-Maximilians-Universität München, Grosshadernerstr. 2, D-82152 Martinsried, Germany; Corresponding author at: Department of Neurology, Ludwig-Maximilians-University, Marchioninistrasse 15, D-81377 Munich, Germany.Department of Neurology, Ludwig-Maximilians-Universität München, Marchioninistr. 15, D-81377 Munich, Germany; Graduate School of Systemic Neurosciences, GSN, Ludwig-Maximilians-Universität München, Grosshadernerstr. 2, D-82152 Martinsried, GermanyDepartment of Neurosurgery, Ludwig-Maximilians-Universität München, Marchioninistr. 15, D-81377 Munich, GermanyDepartment of Neurology, Ludwig-Maximilians-Universität München, Marchioninistr. 15, D-81377 Munich, Germany; Graduate School of Systemic Neurosciences, GSN, Ludwig-Maximilians-Universität München, Grosshadernerstr. 2, D-82152 Martinsried, GermanyLocal field potentials (LFP) of the subthalamic nucleus (STN) recorded during walking may provide clues for determining the function of the STN during gait and also, may be used as biomarker to steer adaptive brain stimulation devices. Here, we present LFP recordings from an implanted sensing neurostimulator (Medtronic Activa PC + S) during walking and rest with and without stimulation in 10 patients with Parkinson's disease and electrodes placed bilaterally in the STN. We also present recordings from two of these patients recorded with externalized leads. We analyzed changes in overall frequency power, bilateral connectivity, high beta frequency oscillatory characteristics and gait-cycle related oscillatory activity. We report that deep brain stimulation improves gait parameters. High beta frequency power (20-30 Hz) and bilateral oscillatory connectivity are reduced during gait, while the attenuation of high beta power is absent during stimulation. Oscillatory characteristics are affected in a similar way. We describe a reduction in overall high beta burst amplitude and burst lifetimes during gait as compared to rest off stimulation. Investigating gait cycle related oscillatory dynamics, we found that alpha, beta and gamma frequency power is modulated in time during gait, locked to the gait cycle. We argue that these changes are related to movement induced artifacts and that these issues have important implications for similar research. Keywords: Deep brain stimulation, Subthalamic nucleus, Gait, Oscillations, Beta rhythmhttp://www.sciencedirect.com/science/article/pii/S2213158218301475 |
| spellingShingle | Franz Hell Annika Plate Jan H. Mehrkens Kai Bötzel Subthalamic oscillatory activity and connectivity during gait in Parkinson's disease NeuroImage: Clinical |
| title | Subthalamic oscillatory activity and connectivity during gait in Parkinson's disease |
| title_full | Subthalamic oscillatory activity and connectivity during gait in Parkinson's disease |
| title_fullStr | Subthalamic oscillatory activity and connectivity during gait in Parkinson's disease |
| title_full_unstemmed | Subthalamic oscillatory activity and connectivity during gait in Parkinson's disease |
| title_short | Subthalamic oscillatory activity and connectivity during gait in Parkinson's disease |
| title_sort | subthalamic oscillatory activity and connectivity during gait in parkinson s disease |
| url | http://www.sciencedirect.com/science/article/pii/S2213158218301475 |
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