Influence of the Introduced Chitin Nanofibrils on Biomedical Properties of Chitosan-Based Materials
Hemorrhage occurring during and after surgery still remains one of the biggest problems in medicine. Although a large number of hemostatic products have been created, there is no universal preparation; thus, the development of new materials is an urgent task. The aim of this research is to increase...
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MDPI AG
2020-05-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/10/5/945 |
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| author | Ekaterina N. Maevskaia Anton S. Shabunin Elena N. Dresvyanina Irina P. Dobrovol’skaya Vladimir E. Yudin Moisey B. Paneyah Andrey M. Fediuk Petr L. Sushchinskii Gerald P. Smirnov Evgeniy V. Zinoviev Pierfrancesco Morganti |
| author_facet | Ekaterina N. Maevskaia Anton S. Shabunin Elena N. Dresvyanina Irina P. Dobrovol’skaya Vladimir E. Yudin Moisey B. Paneyah Andrey M. Fediuk Petr L. Sushchinskii Gerald P. Smirnov Evgeniy V. Zinoviev Pierfrancesco Morganti |
| author_sort | Ekaterina N. Maevskaia |
| collection | DOAJ |
| description | Hemorrhage occurring during and after surgery still remains one of the biggest problems in medicine. Although a large number of hemostatic products have been created, there is no universal preparation; thus, the development of new materials is an urgent task. The aim of this research is to increase hemostatic properties of chitosan by introducing chitin nanofibrils (ChNF). The blood absorbance by ChNF-containing chitosan sponges and time-until-arrest of bleeding were studied. Non-woven materials containing 0.5% of ChNF and materials without chitin were obtained. The studies of ζ-potential showed that the material containing 0.5% ChNF had relatively a high positive charge, but efficiencies of both materials for hemorrhage arrest were comparable to those of commercial hemostatic products (Surgicel and TachoComb). To investigate the interaction between the materials and living organism, histological studies and optical microscopy studies were conducted after implantation of fibers. Despite bioinertness of fibers, implantation of non-woven materials led to formation of significant granulomas. |
| first_indexed | 2024-03-10T19:49:11Z |
| format | Article |
| id | doaj.art-ff2ee753c329447ea2d48b2dfeb0fcbe |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T19:49:11Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-ff2ee753c329447ea2d48b2dfeb0fcbe2023-11-20T00:34:12ZengMDPI AGNanomaterials2079-49912020-05-0110594510.3390/nano10050945Influence of the Introduced Chitin Nanofibrils on Biomedical Properties of Chitosan-Based MaterialsEkaterina N. Maevskaia0Anton S. Shabunin1Elena N. Dresvyanina2Irina P. Dobrovol’skaya3Vladimir E. Yudin4Moisey B. Paneyah5Andrey M. Fediuk6Petr L. Sushchinskii7Gerald P. Smirnov8Evgeniy V. Zinoviev9Pierfrancesco Morganti10Department of Medical Physics, Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya Street 29, 195251 Saint Petersburg, RussiaDepartment of Medical Physics, Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya Street 29, 195251 Saint Petersburg, RussiaDepartment of Medical Physics, Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya Street 29, 195251 Saint Petersburg, RussiaDepartment of Medical Physics, Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya Street 29, 195251 Saint Petersburg, RussiaDepartment of Medical Physics, Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya Street 29, 195251 Saint Petersburg, RussiaLaboratory of Experimental Surgery of Scientific Research Center, Saint Petersburg State Pediatrical Medical University, Litovskaya Street 2, 194100 Saint Petersburg, RussiaLaboratory of Experimental Surgery of Scientific Research Center, Saint Petersburg State Pediatrical Medical University, Litovskaya Street 2, 194100 Saint Petersburg, RussiaLaboratory of Experimental Surgery of Scientific Research Center, Saint Petersburg State Pediatrical Medical University, Litovskaya Street 2, 194100 Saint Petersburg, RussiaInstitute of Textile and Fashion, Saint Petersburg State University of Industrial Technologies and Design, Bolshaya Morskaya Street 18, 191186 Saint Petersburg, RussiaLaboratory of Experimental Surgery of Scientific Research Center, Saint Petersburg State Pediatrical Medical University, Litovskaya Street 2, 194100 Saint Petersburg, RussiaDepartment of Experimental Medicine, University of Campania Luigi Vanvitelli, via L. De Crecchio 7, 80138 Naples, ItalyHemorrhage occurring during and after surgery still remains one of the biggest problems in medicine. Although a large number of hemostatic products have been created, there is no universal preparation; thus, the development of new materials is an urgent task. The aim of this research is to increase hemostatic properties of chitosan by introducing chitin nanofibrils (ChNF). The blood absorbance by ChNF-containing chitosan sponges and time-until-arrest of bleeding were studied. Non-woven materials containing 0.5% of ChNF and materials without chitin were obtained. The studies of ζ-potential showed that the material containing 0.5% ChNF had relatively a high positive charge, but efficiencies of both materials for hemorrhage arrest were comparable to those of commercial hemostatic products (Surgicel and TachoComb). To investigate the interaction between the materials and living organism, histological studies and optical microscopy studies were conducted after implantation of fibers. Despite bioinertness of fibers, implantation of non-woven materials led to formation of significant granulomas.https://www.mdpi.com/2079-4991/10/5/945chitosanchitin nanofibrilshemostatic materialhemorrhage |
| spellingShingle | Ekaterina N. Maevskaia Anton S. Shabunin Elena N. Dresvyanina Irina P. Dobrovol’skaya Vladimir E. Yudin Moisey B. Paneyah Andrey M. Fediuk Petr L. Sushchinskii Gerald P. Smirnov Evgeniy V. Zinoviev Pierfrancesco Morganti Influence of the Introduced Chitin Nanofibrils on Biomedical Properties of Chitosan-Based Materials Nanomaterials chitosan chitin nanofibrils hemostatic material hemorrhage |
| title | Influence of the Introduced Chitin Nanofibrils on Biomedical Properties of Chitosan-Based Materials |
| title_full | Influence of the Introduced Chitin Nanofibrils on Biomedical Properties of Chitosan-Based Materials |
| title_fullStr | Influence of the Introduced Chitin Nanofibrils on Biomedical Properties of Chitosan-Based Materials |
| title_full_unstemmed | Influence of the Introduced Chitin Nanofibrils on Biomedical Properties of Chitosan-Based Materials |
| title_short | Influence of the Introduced Chitin Nanofibrils on Biomedical Properties of Chitosan-Based Materials |
| title_sort | influence of the introduced chitin nanofibrils on biomedical properties of chitosan based materials |
| topic | chitosan chitin nanofibrils hemostatic material hemorrhage |
| url | https://www.mdpi.com/2079-4991/10/5/945 |
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