Assembly of fluorophore J-aggregates with nanospacer onto mesoporous nanoparticles for enhanced photoacoustic imaging
Many fluorophores, such as indocyanine green (ICG), have poor photostability and low photothermal efficiency hindering their wide application in photoacoustic (PA) tomography. In the present study, a supramolecular assembly approach was used to develop the hybrid nanoparticles (Hy NPs) of ICG and por...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Photoacoustics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597923001052 |
| _version_ | 1797643638977593344 |
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| author | Wujun Xu Jarkko Leskinen Teemu Sahlström Emilia Happonen Tanja Tarvainen Vesa-Pekka Lehto |
| author_facet | Wujun Xu Jarkko Leskinen Teemu Sahlström Emilia Happonen Tanja Tarvainen Vesa-Pekka Lehto |
| author_sort | Wujun Xu |
| collection | DOAJ |
| description | Many fluorophores, such as indocyanine green (ICG), have poor photostability and low photothermal efficiency hindering their wide application in photoacoustic (PA) tomography. In the present study, a supramolecular assembly approach was used to develop the hybrid nanoparticles (Hy NPs) of ICG and porous silicon (PSi) as a novel contrast agent for PA tomography. ICG was assembled on the PSi NPs to form J-aggregates within 30 min. The Hy NPs presented a red-shifted absorption, improved photothermal stability, and enhanced PA performance. Furthermore, 1-dodecene (DOC) was assembled into the NPs as a ‘nanospacer’, which enhanced non-radiative decay for increased thermal release. Compared to the Hy NPs, adding DOC into the Hy NPs (DOC-Hy) increased the PA signal by 83%. Finally, the DOC-Hy was detectable in PA tomography at 1.5 cm depth in tissue phantom even though its concentration was as low as 6.25 µg/mL, indicating the potential for deep tissue PA imaging. |
| first_indexed | 2024-03-11T14:17:49Z |
| format | Article |
| id | doaj.art-ff2f4a22599f439b89c23a8f8924230b |
| institution | Directory Open Access Journal |
| issn | 2213-5979 |
| language | English |
| last_indexed | 2024-03-11T14:17:49Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj.art-ff2f4a22599f439b89c23a8f8924230b2023-11-01T04:47:09ZengElsevierPhotoacoustics2213-59792023-10-0133100552Assembly of fluorophore J-aggregates with nanospacer onto mesoporous nanoparticles for enhanced photoacoustic imagingWujun Xu0Jarkko Leskinen1Teemu Sahlström2Emilia Happonen3Tanja Tarvainen4Vesa-Pekka Lehto5Department of Technical Physics, University of Eastern Finland, 70210 Kuopio, FinlandDepartment of Technical Physics, University of Eastern Finland, 70210 Kuopio, FinlandDepartment of Technical Physics, University of Eastern Finland, 70210 Kuopio, FinlandDepartment of Technical Physics, University of Eastern Finland, 70210 Kuopio, FinlandDepartment of Technical Physics, University of Eastern Finland, 70210 Kuopio, FinlandCorresponding author.; Department of Technical Physics, University of Eastern Finland, 70210 Kuopio, FinlandMany fluorophores, such as indocyanine green (ICG), have poor photostability and low photothermal efficiency hindering their wide application in photoacoustic (PA) tomography. In the present study, a supramolecular assembly approach was used to develop the hybrid nanoparticles (Hy NPs) of ICG and porous silicon (PSi) as a novel contrast agent for PA tomography. ICG was assembled on the PSi NPs to form J-aggregates within 30 min. The Hy NPs presented a red-shifted absorption, improved photothermal stability, and enhanced PA performance. Furthermore, 1-dodecene (DOC) was assembled into the NPs as a ‘nanospacer’, which enhanced non-radiative decay for increased thermal release. Compared to the Hy NPs, adding DOC into the Hy NPs (DOC-Hy) increased the PA signal by 83%. Finally, the DOC-Hy was detectable in PA tomography at 1.5 cm depth in tissue phantom even though its concentration was as low as 6.25 µg/mL, indicating the potential for deep tissue PA imaging.http://www.sciencedirect.com/science/article/pii/S2213597923001052NanoparticlesContrast agentsImagingPhotoacousticsNanospacerMesoporous silicon |
| spellingShingle | Wujun Xu Jarkko Leskinen Teemu Sahlström Emilia Happonen Tanja Tarvainen Vesa-Pekka Lehto Assembly of fluorophore J-aggregates with nanospacer onto mesoporous nanoparticles for enhanced photoacoustic imaging Photoacoustics Nanoparticles Contrast agents Imaging Photoacoustics Nanospacer Mesoporous silicon |
| title | Assembly of fluorophore J-aggregates with nanospacer onto mesoporous nanoparticles for enhanced photoacoustic imaging |
| title_full | Assembly of fluorophore J-aggregates with nanospacer onto mesoporous nanoparticles for enhanced photoacoustic imaging |
| title_fullStr | Assembly of fluorophore J-aggregates with nanospacer onto mesoporous nanoparticles for enhanced photoacoustic imaging |
| title_full_unstemmed | Assembly of fluorophore J-aggregates with nanospacer onto mesoporous nanoparticles for enhanced photoacoustic imaging |
| title_short | Assembly of fluorophore J-aggregates with nanospacer onto mesoporous nanoparticles for enhanced photoacoustic imaging |
| title_sort | assembly of fluorophore j aggregates with nanospacer onto mesoporous nanoparticles for enhanced photoacoustic imaging |
| topic | Nanoparticles Contrast agents Imaging Photoacoustics Nanospacer Mesoporous silicon |
| url | http://www.sciencedirect.com/science/article/pii/S2213597923001052 |
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