Ionizable Lipid Nanoparticles Enhanced the Synergistic Adjuvant Effect of CpG ODNs and QS21 in a Varicella Zoster Virus Glycoprotein E Subunit Vaccine

Ionizable Lipid Nanoparticles Enhanced the Synergistic Adjuvant Effect of CpG ODNs and QS21 in a Varicella Zoster Virus Glycoprotein E Subunit Vaccine

Varicella zoster virus (VZV) causes two diseases: varicella upon primary infection and herpes zoster when latent viruses in the sensory ganglia reactivate. While varicella vaccines depend on humoral immunity to prevent VZV infection, cell-mediated immunity (CMI), which plays a therapeutic role in th...

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Bibliographic Details
Main Authors: Ning Luan, Han Cao, Yunfei Wang, Kangyang Lin, Cunbao Liu
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceutics
Subjects:
varicella zoster virus
subunit vaccine
adjuvant
lipid nanoparticle
CpG ODNs (CpG oligodeoxynucleotides)
QS21
Online Access:https://www.mdpi.com/1999-4923/14/5/973

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