System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function
Background and objective: The understanding of complex biological systems performance is one of the key issues in physiology, and several computational methods based on computer simulation have been applied to determine the behaviour of nonlinear systems. System Dynamics is an intuitive modelling me...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Informatics in Medicine Unlocked |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352914818302545 |
| _version_ | 1828309121550516224 |
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| author | J. Fernandez de Canete V. Pimentel J. Barbancho A. Luque |
| author_facet | J. Fernandez de Canete V. Pimentel J. Barbancho A. Luque |
| author_sort | J. Fernandez de Canete |
| collection | DOAJ |
| description | Background and objective: The understanding of complex biological systems performance is one of the key issues in physiology, and several computational methods based on computer simulation have been applied to determine the behaviour of nonlinear systems. System Dynamics is an intuitive modelling methodology based on qualitative reasoning, whereby a conceptual physiological model can be described as a set of cause–effect relationships between the physiological variables of a system, so that a set of dynamic equations describing the system behaviour quantitatively can be derived. Methods: This paper presents system dynamics modelling methodology and its application for short-term arterial pressure control exerted through the baroreceptor reflex over a multi-compartmental cardiovascular model under the OpenModelica object-oriented simulation environment. Results: The performance of the controlled system is analysed by simulation in light of the existing hypothesis and validation tests previously performed, demonstrating the effectiveness of the short-term regulation mechanism under physiological and pathological conditions. Conclusions: The system dynamics can be viewed as a powerful and easy-to-use educational tool and useful in Health Sciences so as to explain the behaviour of a physiologic system under study. Keywords: System dynamics, Causal diagram modelling, Cardiovascular system, Arterial pressure control, OpenModelica simulation environment |
| first_indexed | 2024-04-13T15:23:57Z |
| format | Article |
| id | doaj.art-ff3015e547d14253abcc6b37f6a8aac9 |
| institution | Directory Open Access Journal |
| issn | 2352-9148 |
| language | English |
| last_indexed | 2024-04-13T15:23:57Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Informatics in Medicine Unlocked |
| spelling | doaj.art-ff3015e547d14253abcc6b37f6a8aac92022-12-22T02:41:34ZengElsevierInformatics in Medicine Unlocked2352-91482019-01-0115System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular functionJ. Fernandez de Canete0V. Pimentel1J. Barbancho2A. Luque3Dpt. de Ing. de Sistemas y Automatica, E.T.S.I. Industriales, Campus de Teatinos, 29071, Malaga, Spain; Corresponding author.Dpt. de Ing. de Sistemas y Automatica, E.T.S.I. Industriales, Campus de Teatinos, 29071, Malaga, SpainDpt. de Tecnologia Electronica, E.T.S.I. Informatica, Av. Reina Mercedes, 41010, Sevilla, SpainDpt. de Ingenieria del Diseno, Escuela Politecnica Superior, C/ Virgen de Africa 7, 41011, Sevilla, SpainBackground and objective: The understanding of complex biological systems performance is one of the key issues in physiology, and several computational methods based on computer simulation have been applied to determine the behaviour of nonlinear systems. System Dynamics is an intuitive modelling methodology based on qualitative reasoning, whereby a conceptual physiological model can be described as a set of cause–effect relationships between the physiological variables of a system, so that a set of dynamic equations describing the system behaviour quantitatively can be derived. Methods: This paper presents system dynamics modelling methodology and its application for short-term arterial pressure control exerted through the baroreceptor reflex over a multi-compartmental cardiovascular model under the OpenModelica object-oriented simulation environment. Results: The performance of the controlled system is analysed by simulation in light of the existing hypothesis and validation tests previously performed, demonstrating the effectiveness of the short-term regulation mechanism under physiological and pathological conditions. Conclusions: The system dynamics can be viewed as a powerful and easy-to-use educational tool and useful in Health Sciences so as to explain the behaviour of a physiologic system under study. Keywords: System dynamics, Causal diagram modelling, Cardiovascular system, Arterial pressure control, OpenModelica simulation environmenthttp://www.sciencedirect.com/science/article/pii/S2352914818302545 |
| spellingShingle | J. Fernandez de Canete V. Pimentel J. Barbancho A. Luque System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function Informatics in Medicine Unlocked |
| title | System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function |
| title_full | System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function |
| title_fullStr | System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function |
| title_full_unstemmed | System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function |
| title_short | System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function |
| title_sort | system dynamics modelling approach in health sciences application to the regulation of the cardiovascular function |
| url | http://www.sciencedirect.com/science/article/pii/S2352914818302545 |
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