Deciphering the Long Non-Coding RNAs and MicroRNAs Coregulation Networks in Ovarian Cancer Development: An Overview
Non-coding RNAs are emergent elements from the genome, which do not encode for proteins but have relevant cellular functions impacting almost all the physiological processes occurring in eukaryotic cells. In particular, microRNAs and long non-coding RNAs (lncRNAs) are a new class of small RNAs trans...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/6/1407 |
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| author | César López-Camarillo Erika Ruíz-García Yarely M. Salinas-Vera Macrina B. Silva-Cázares Olga N. Hernández-de la Cruz Laurence A. Marchat Dolores Gallardo-Rincón |
| author_facet | César López-Camarillo Erika Ruíz-García Yarely M. Salinas-Vera Macrina B. Silva-Cázares Olga N. Hernández-de la Cruz Laurence A. Marchat Dolores Gallardo-Rincón |
| author_sort | César López-Camarillo |
| collection | DOAJ |
| description | Non-coding RNAs are emergent elements from the genome, which do not encode for proteins but have relevant cellular functions impacting almost all the physiological processes occurring in eukaryotic cells. In particular, microRNAs and long non-coding RNAs (lncRNAs) are a new class of small RNAs transcribed from the genome, which modulate the expression of specific genes at transcriptional and posttranscriptional levels, thus adding a new regulatory layer in the flux of genetic information. In cancer cells, the miRNAs and lncRNAs interactions with its target genes and functional pathways are deregulated as a consequence of epigenetic and genetic alterations occurring during tumorigenesis. In this review, we summarize the actual knowledge on the interplay of lncRNAs with its cognate miRNAs and mRNAs pairs, which interact in coregulatory networks with a particular emphasis on the mechanisms underlying its oncogenic behavior in ovarian cancer. Specifically, we reviewed here the evidences unraveling the relevant roles of lncRNAs/miRNAs pairs in altered regulation of cell migration, angiogenesis, therapy resistance, and Warburg effect. Finally, we also discussed its potential clinical implications in ovarian cancer and related endocrine disease therapies. |
| first_indexed | 2024-03-10T10:40:35Z |
| format | Article |
| id | doaj.art-ff30fbc74f684e86b821ba00afca5d50 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T10:40:35Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-ff30fbc74f684e86b821ba00afca5d502023-11-21T23:00:37ZengMDPI AGCells2073-44092021-06-01106140710.3390/cells10061407Deciphering the Long Non-Coding RNAs and MicroRNAs Coregulation Networks in Ovarian Cancer Development: An OverviewCésar López-Camarillo0Erika Ruíz-García1Yarely M. Salinas-Vera2Macrina B. Silva-Cázares3Olga N. Hernández-de la Cruz4Laurence A. Marchat5Dolores Gallardo-Rincón6Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, 03100 CDMX, MexicoGrupo de Investigación en Cáncer de Ovario y Endometrio, Instituto Nacional de Cancerología, 14080 CDMX, MexicoDepartamento de Bioquímica, CINVESTAV-IPN, 07360 CDMX, MexicoCoordinación Académica Región Altiplano, Universidad Autónoma de San Luis Potosí, 78700 San Luis Potosí, MexicoPosgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, 03100 CDMX, MexicoPrograma en Biomedicina Molecular y Red de Biotecnología, Instituto Politécnico Nacional, 07340 CDMX, MexicoGrupo de Investigación en Cáncer de Ovario y Endometrio, Instituto Nacional de Cancerología, 14080 CDMX, MexicoNon-coding RNAs are emergent elements from the genome, which do not encode for proteins but have relevant cellular functions impacting almost all the physiological processes occurring in eukaryotic cells. In particular, microRNAs and long non-coding RNAs (lncRNAs) are a new class of small RNAs transcribed from the genome, which modulate the expression of specific genes at transcriptional and posttranscriptional levels, thus adding a new regulatory layer in the flux of genetic information. In cancer cells, the miRNAs and lncRNAs interactions with its target genes and functional pathways are deregulated as a consequence of epigenetic and genetic alterations occurring during tumorigenesis. In this review, we summarize the actual knowledge on the interplay of lncRNAs with its cognate miRNAs and mRNAs pairs, which interact in coregulatory networks with a particular emphasis on the mechanisms underlying its oncogenic behavior in ovarian cancer. Specifically, we reviewed here the evidences unraveling the relevant roles of lncRNAs/miRNAs pairs in altered regulation of cell migration, angiogenesis, therapy resistance, and Warburg effect. Finally, we also discussed its potential clinical implications in ovarian cancer and related endocrine disease therapies.https://www.mdpi.com/2073-4409/10/6/1407long non-coding RNAsmicroRNAsco-regulation networksgene expressionovarian cancer |
| spellingShingle | César López-Camarillo Erika Ruíz-García Yarely M. Salinas-Vera Macrina B. Silva-Cázares Olga N. Hernández-de la Cruz Laurence A. Marchat Dolores Gallardo-Rincón Deciphering the Long Non-Coding RNAs and MicroRNAs Coregulation Networks in Ovarian Cancer Development: An Overview Cells long non-coding RNAs microRNAs co-regulation networks gene expression ovarian cancer |
| title | Deciphering the Long Non-Coding RNAs and MicroRNAs Coregulation Networks in Ovarian Cancer Development: An Overview |
| title_full | Deciphering the Long Non-Coding RNAs and MicroRNAs Coregulation Networks in Ovarian Cancer Development: An Overview |
| title_fullStr | Deciphering the Long Non-Coding RNAs and MicroRNAs Coregulation Networks in Ovarian Cancer Development: An Overview |
| title_full_unstemmed | Deciphering the Long Non-Coding RNAs and MicroRNAs Coregulation Networks in Ovarian Cancer Development: An Overview |
| title_short | Deciphering the Long Non-Coding RNAs and MicroRNAs Coregulation Networks in Ovarian Cancer Development: An Overview |
| title_sort | deciphering the long non coding rnas and micrornas coregulation networks in ovarian cancer development an overview |
| topic | long non-coding RNAs microRNAs co-regulation networks gene expression ovarian cancer |
| url | https://www.mdpi.com/2073-4409/10/6/1407 |
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